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  4. Recombinant Human Hydroxyacylglutathione hydrolase, mitochondrial (HAGH)

Recombinant Human Hydroxyacylglutathione hydrolase, mitochondrial (HAGH)

  • 中文名称：
    人HAGH重组蛋白
  • 货号：
    CSB-YP624118HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人HAGH重组蛋白
  • 货号：
    CSB-EP624118HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人HAGH重组蛋白
  • 货号：
    CSB-EP624118HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人HAGH重组蛋白
  • 货号：
    CSB-BP624118HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人HAGH重组蛋白
  • 货号：
    CSB-MP624118HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HAGH
  • Uniprot No.：
    Q16775
  • 别名：
    HAGH; GLO2; HAGH1Hydroxyacylglutathione hydrolase; mitochondrial; EC 3.1.2.6; Glyoxalase II; Glx II
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    14-308
  • 氨基酸序列
    AALGAAC ARRGLGPALL GVFCHTDLRK NLTVDEGTMK VEVLPALTDN YMYLVIDDET KEAAIVDPVQ PQKVVDAARK HGVKLTTVLT THHHWDHAGG NEKLVKLESG LKVYGGDDRI GALTHKITHL STLQVGSLNV KCLATPCHTS GHICYFVSKP GGSEPPAVFT GDTLFVAGCG KFYEGTADEM CKALLEVLGR LPPDTRVYCG HEYTINNLKF ARHVEPGNAA IREKLAWAKE KYSIGEPTVP STLAEEFTYN PFMRVREKTV QQHAGETDPV TTMRAVRREK DQFKMPRD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

相关产品

HAGH antibodies

HAGH Proteins

靶点详情

  • 功能：
    Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
  • 基因功能参考文献：
    1. Down regulation of Glyoxalase II was observed in cases of diabetic retinopathy as compared to controls. PMID: 29950256
    2. The critical role of glyoxalases as regulators of tumorigenesis in the prostate through modulation of various critical signaling pathways, and an overview of the current knowledge on glyoxalases in bladder, kidney and testis cancers is reviewed. (GLO1, GLO2) PMID: 29385039
    3. epidermal expression stronger in older skin donors PMID: 26914966
    4. Glo2, together with Glo1, represents a novel mechanism in prostate cancer progression as part of a pathway driven by PTEN/PI3K/AKT/mTOR signaling. PMID: 27696457
    5. This article reports for the first time a possible additional role of Glo2 that, after interacting with a target protein, is able to promote S-glutathionylation. PMID: 27935136
    6. This study suggested that HAGH, rs11859266 and rs3743852 showed significant associations with schizophrenia in males at allelic and genotype levels. PMID: 25645869
    7. No association between genetic variants of the HAGH gene and autism spectrum disorder was found. PMID: 24671236
    8. hydroxyacylglutathione hydrolase (HAGH) gene encodes both cytosolic and mitochondrial forms of glyoxalase II PMID: 15117945
    9. Overexpression of glyoxalase II is associated with kidney tumor PMID: 16803681
    10. Data show that the GLX2 gene, which encodes glyoxalase II enzyme, is up-regulated by p63 and p73. PMID: 16831876
    11. In androgen-dependent prostate cancer cells, testosterone upregulates GLO2 mRNA levels. In androgen-independent prostate cancer cells, it downregulates GLO2 mRNA. PMID: 18344682
    12. Human glyoxalase II contains an Fe(II)Zn(II) center but is active as a mononuclear Zn(II) enzyme PMID: 19413286

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  • 亚细胞定位：
    [Isoform 1]: Mitochondrion matrix.; [Isoform 2]: Cytoplasm.
  • 蛋白家族：
    Metallo-beta-lactamase superfamily, Glyoxalase II family
  • 组织特异性：
    Expressed in liver and kidney.
  • 数据库链接：

    HGNC: 4805

    OMIM: 138760

    KEGG: hsa:3029

    STRING: 9606.ENSP00000380514

    UniGene: Hs.157394

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