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  4. Recombinant Human Histone-lysine N-methyltransferase ASH1L (ASH1L), partial

Recombinant Human Histone-lysine N-methyltransferase ASH1L (ASH1L), partial

  • 中文名称：
    Recombinant Human Histone-lysine N-methyltransferase ASH1L(ASH1L) ,partial
  • 货号：
    CSB-YP865114HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Histone-lysine N-methyltransferase ASH1L(ASH1L) ,partial
  • 货号：
    CSB-EP865114HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Histone-lysine N-methyltransferase ASH1L(ASH1L) ,partial
  • 货号：
    CSB-EP865114HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Histone-lysine N-methyltransferase ASH1L(ASH1L) ,partial
  • 货号：
    CSB-BP865114HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Histone-lysine N-methyltransferase ASH1L(ASH1L) ,partial
  • 货号：
    CSB-MP865114HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ASH1L
  • Uniprot No.：
    Q9NR48
  • 别名：
    Absent small and homeotic disks protein 1 homolog; Absent Small or Homeotic Like ; Absent Small or Homeotic Like; ASH 1; ASH 1L; ash1 (absent small or homeotic 1); Ash1 (absent small or homeotic) like; ASH1-like protein; ASH1L; ASH1L_HUMAN; ASH1L1; FLJ10504; huASH1; KIAA1420; KMT2H / ASH1; Lysine N-methyltransferase 2H; Probable histone-lysine N-methyltransferase ASH1L
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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ASH1L antibodies

靶点详情

  • 功能：
    Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The physiological significance of the H3K9me1 activity is unclear.
  • 基因功能参考文献：
    1. DDB2 promotes cyclobutane pyrimidine dimer excision by recruiting the histone methyltransferase ASH1L, which methylates lysine 4 of histone H3. In turn, methylated H3 facilitates the docking of the XPC complex to nucleosomal histone octamers. PMID: 29109511
    2. suppresses matrix metalloproteinase through mitogen-activated protein kinase signaling pathway in pulpitis PMID: 28041684
    3. There has been increasing evidence that heterozygous mutation of ASH1L is associated with ID and autism spectrum disorders. We suggest that ASH1L abnormalities may cause a novel MCA/ID syndrome. PMID: 28394464
    4. Epigenetic regulators play vital roles in cancer pathogenesis and represent a new frontier in therapeutic targeting. Our studies provide basic mechanistic insight into the role of H3K36me2 in transcription activation and MLL leukemia pathogenesis and implicate ASH1L histone methyltransferase as a promising target for novel molecular therapy. PMID: 27154821
    5. Our data suggest a role for ASH1L, a methyl transferase protein and member of the trithorax (Trx) family, in regulation of the HBB gene and as a potential modifier of beta-thalassaemia severity. PMID: 27434206
    6. Structural features were identified in ASH1L related to its' function and enzymatic activity. PMID: 26292256
    7. Both ASH1L and SETD2 are H3K36 specific methyltransferases but only SETD2 can trimethylate this mark. PMID: 26002201
    8. These data demonstrate that miR-142-3p downregulation has a role in thyroid tumorigenesis, by regulating ASH1L and MLL1. PMID: 25238203
    9. Our results uncover a novel regulatory cascade orchestrated by Ash1l with RAR and provide insights into mechanisms underlying the establishment of the transcriptional activation that counteracts Polycomb silencing PMID: 24244179
    10. all of the H3K36-specific methyltransferases, including ASH1L, HYPB, NSD1, and NSD2 were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a, and Pr-Set7 were not affected by ubH2A. PMID: 24019522
    11. induction of Cdk5 activity is a novel mechanism through which hASH1 may regulate migration in lung carcinogenesis PMID: 22696682
    12. Long Non-coding RNA, DBE-T recruits the Trithorax group protein Ash1L to the FSHD locus, driving histone H3 lysine 36 dimethylation, chromatin remodeling, and 4q35 gene transcription. PMID: 22541069
    13. ASH1 and MLL1 synergize in activation of Hox genes. PMID: 22140534
    14. human ASH1L specifically methylates histone H3 Lys-36. PMID: 21239497
    15. These data suggest that ASH1L occupies most, if not all, active genes and methylates histone H3 in a nonredundant fashion at a subset of genes. PMID: 17923682

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  • 亚细胞定位：
    Nucleus. Cell junction, tight junction. Chromosome.
  • 蛋白家族：
    Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, SET2 subfamily
  • 组织特异性：
    Widely expressed, with highest level in brain, heart and kidney.
  • 数据库链接：

    HGNC: 19088

    OMIM: 607999

    KEGG: hsa:55870

    STRING: 9606.ENSP00000376204

    UniGene: Hs.491060

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