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  4. Recombinant Human Histone acetyltransferase KAT6B (KAT6B), partial

Recombinant Human Histone acetyltransferase KAT6B (KAT6B), partial

  • 中文名称：
    人KAT6B重组蛋白
  • 货号：
    CSB-YP855507HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人KAT6B重组蛋白
  • 货号：
    CSB-EP855507HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人KAT6B重组蛋白
  • 货号：
    CSB-EP855507HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人KAT6B重组蛋白
  • 货号：
    CSB-BP855507HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人KAT6B重组蛋白
  • 货号：
    CSB-MP855507HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    KAT6B
  • Uniprot No.：
    Q8WYB5
  • 别名：
    DKFZp313G1618; FLJ90335; Histone acetyltransferase MORF; Histone acetyltransferase MOZ2; Histone acetyltransferase MYST4; KAT 6B; KIAA0383; Monocytic leukemia zinc finger protein related factor; Monocytic leukemia zinc finger protein-related factor; MOZ 2; MOZ; MOZ related factor; MOZ YBF2/SAS3 SAS2 and TIP60 protein 4; MOZ2; MYST 4; MYST histone acetyltransferase (monocytic leukemia) 4; MYST protein 4; MYST-4; MYST4; MYST4_HUMAN; OTTHUMP00000019866; OTTHUMP00000019867; OTTHUMP00000019869; OTTHUMP00000019870; QKF; Querkopf; SAS2 and TIP60 protein 4; YBF2/SAS3
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.
  • 基因功能参考文献：
    1. KAT6B mutation is associated with Craniosynostosis. PMID: 28696035
    2. chronic inflammation compromises unfolded protein response function through MORF-mediated-PERK transcription. PMID: 27447113
    3. With ptosis, hypotonia, and developmental delay as the main diagnostic features of our patient, the effect of histone acetyltransferase-encoding KAT6B gene haploinsufficiency was suspected to have a significant role in determining the phenotype. PMID: 27880066
    4. Study identified the double plant homeodomain finger (DPF) of the lysine acetyltransferase MORF as a reader of global histone H3K14 acylation. PMID: 28286003
    5. Our findings support that phenotypes associated with typical KAT6B disease-causing variants should be referred to as 'KAT6B spectrum disorders' or 'KAT6B related disorders', rather than their current SBBYSS and GTPTS classification PMID: 27452416
    6. Studies show that misregulation of MOZ/MORF results in tumorigenesis and developmental disorders. Results also provide evidence that these 2 proteins play important role in regulating cell proliferation and stem cell maintenance. [review] PMID: 27185879
    7. Kat6 c.3147G>A splice site mutation causes Say-Barber-Biesecker/Young-Simpson syndrome by inducing aberrant splicing. PMID: 26334766
    8. KAT6B sequence variants are being reported in the Say-Barber-Biesecker type of blepharophimosis mental retardation syndromes (SBBS) and in the more severe genitopatellar syndrome. PMID: 25424711
    9. This study shown MYST4 to be the risk factor for attention deficit/hyperactivity disorder. PMID: 25840828
    10. Homozygous deletions of KAT6B and the loss of its mRNA occur in SCLC cell lines and primary tumors. KAT6B loss enhances cancer growth. Restoration induces tumor suppressor-like features involving a new type of histone H3 Lys23 acetyltransferase activity. PMID: 26208904
    11. The relationship between MYO1C and KAT6B suggests that the two are interacting in chromatin remodelling for gene expression in human masseter muscle. This is the nuclear myosin1 (NM1) function of MYO1C. PMID: 24698832
    12. Similar to those observed in other genetic disorders resulting from KAT6B mutations. PMID: 24458743
    13. The study showed that markers rs11001178 (MYST4) showed weak associations. PMID: 24444492
    14. MORF double PHD finger binds to Histone H3 in a manner that is enhanced by acetylation of the lysine residues K9 and K14 PMID: 24150941
    15. Our results confirm the implication of KAT6B mutations in typical SBBYS syndrome and emphasize the importance of genotype-phenotype correlations at the KAT6B locus. PMID: 23436491
    16. Propose that haploinsufficiency or loss of a function mediated by the C-terminal domain causes the common features, whereas gain-of-function activities would explain the features unique to genitopatellar syndrome. Review. PMID: 22715153
    17. These data suggest that the tandem of plant homeodomain 1/2 fingers play a role in MOZ and MORF histone acetyltransferase association with histon H3 regions enriched in acetylated marks. PMID: 23063713
    18. By exome sequencing, we found de novo heterozygous truncating mutations in KAT6B. PMID: 22265014
    19. we identified de novo mutations of KAT6B in five individuals with Genitopatellar syndrome. PMID: 22265017
    20. Whole-exome-sequencing identifies mutations in histone acetyltransferase gene KAT6B in individuals with the Say-Barber-Biesecker variant of Ohdo syndrome PMID: 22077973
    21. Recognition of unmodified histone H3 by the first PHD finger of bromodomain-PHD finger protein 2 provides insights into the regulation of histone acetyltransferases monocytic leukemic zinc-finger protein (MOZ) and MOZ-related factor (MORF). PMID: 21880731
    22. Data show that H3 acetylation by Myst4 is important for neural, craniofacial, and skeletal morphogenesis, mainly through its ability to specifically regulating the MAPK signaling pathway. PMID: 21804188
    23. role in regulating interleukin-5 expression PMID: 15271374
    24. These findings indicate that BRPF proteins play a key role in assembling and activating MOZ/MORF acetyltransferase complexes. PMID: 18794358

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  • 相关疾病：
    Ohdo syndrome, SBBYS variant (SBBYSS); Genitopatellar syndrome (GTPTS)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    MYST (SAS/MOZ) family
  • 组织特异性：
    Ubiquitously expressed, with high levels in heart, pancreas, testis and ovary.
  • 数据库链接：

    HGNC: 17582

    OMIM: 603736

    KEGG: hsa:23522

    STRING: 9606.ENSP00000287239

    UniGene: Hs.35758

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