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  4. Recombinant Human Helicase SRCAP (SRCAP), partial

Recombinant Human Helicase SRCAP (SRCAP), partial

  • 中文名称：
    人SRCAP重组蛋白
  • 货号：
    CSB-YP751175HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SRCAP重组蛋白
  • 货号：
    CSB-EP751175HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SRCAP重组蛋白
  • 货号：
    CSB-EP751175HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SRCAP重组蛋白
  • 货号：
    CSB-BP751175HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SRCAP重组蛋白
  • 货号：
    CSB-MP751175HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SRCAP
  • Uniprot No.：
    Q6ZRS2
  • 别名：
    SRCAP; KIAA0309; Helicase SRCAP; EC 3.6.4.-; Domino homolog 2; Snf2-related CBP activator
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription.
  • 基因功能参考文献：
    1. Data show that PCI domain-containing protein 2 (Pcid2) controls lymphoid lineage commitment through the regulation of Snf2-related CREBBP activator protein (SRCAP) remodelling activity. PMID: 29138493
    2. Alterative hypotheses to explain how the Srcap truncating mutations lead to the onset of Floating-Harbor syndrome are presented. PMID: 27208210
    3. Data confirm a mutational hot spot in the final exon of SRCAP in the majority of Floating-Harbor syndrome patients but also show that exon 33 of this gene can be affected. PMID: 25433523
    4. This study implicates the human SRCAP chromatin remodeling complex as a novel regulator of DNA damage responses that orchestrates proper signaling and repair of DSBs in the context of chromatin. PMID: 25176633
    5. Functional studies and reports of patients with additional SRCAP mutations will eventually lead to a better understanding of biological mechanisms underlying this disorder. PMID: 23763483
    6. These results indicate that perturbed skeletal maturation from infancy through adolescence is a characteristic feature in patients with SRCAP mutations. PMID: 24375913
    7. Sequencing of the SRCAP gene demonstrated a de novo mutation matching one of the known FHS-associated mutations. PMID: 23165645
    8. Data indicate that the absence of SRCAP mutations in 3/9 cases suggesting genetic heterogeneity of floating-harbor syndrome (FH syndrome). PMID: 22965468
    9. Our genome-wide expression results demonstrate that SRCAP-mediated H2A.Z deposition at promoter regions is necessary for complete gene reactivation induced by DNA demethylation. PMID: 22479200
    10. Sanger sequencing identified mutations in SRCAP in eight more affected persons. PMID: 22265015
    11. HCV NS3 protein is involved in the activation of the Notch-signaling pathway through the targeting to both SRCAP and p400 PMID: 21673954
    12. These data identify SRCAP as a physiologically relevant mediator of PSA expression, and demonstrate that SRCAP plays a role in prostate cancer cell proliferation. PMID: 20432434
    13. SRCAP functions as a coactivator to regulate transcription initiated by several signaling pathways. PMID: 14500758
    14. SRCAP is implicated in developmental gene activation PMID: 16024792
    15. SRCAP-containing complex supports ATP-dependent exchange of histone dimers containing H2B and H2A.Z into mononucleosomes reconstituted with recombinant H2A, H2B, H3, and H4. PMID: 16634648
    16. Methods for purification and assay of the SRCAP chromatin remodeling complexes are described. PMID: 17101442
    17. SRCAP is recruited to promoters and is critical for the deposition of H2A.Z. PMID: 17617668

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  • 相关疾病：
    Floating-Harbor syndrome (FLHS)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    SNF2/RAD54 helicase family, SWR1 subfamily
  • 数据库链接：

    HGNC: 16974

    OMIM: 136140

    KEGG: hsa:10847

    STRING: 9606.ENSP00000262518

    UniGene: Hs.620916

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