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  4. Recombinant Human Golgi apparatus protein 1 (GLG1), partial

Recombinant Human Golgi apparatus protein 1 (GLG1), partial

  • 中文名称：
    人GLG1重组蛋白
  • 货号：
    CSB-YP009498HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人GLG1重组蛋白
  • 货号：
    CSB-EP009498HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人GLG1重组蛋白
  • 货号：
    CSB-EP009498HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人GLG1重组蛋白
  • 货号：
    CSB-BP009498HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人GLG1重组蛋白
  • 货号：
    CSB-MP009498HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    GLG1
  • Uniprot No.：
    Q92896
  • 别名：
    AI593353; AW537898; CFR 1 ; CFR-1; CFR1; Cys -rich FGF Receptor; Cysteine rich fibroblast growth factor receptor; Cysteine-rich fibroblast growth factor receptor; DKFZp686L08213; E selectin ligand 1; E-selectin ligand 1; ESL 1; ESL-1; ESL1; FLJ23319; FLJ23967; FLJ32797; GLG1; Golgi apparatus protein 1; golgi glycoprotein 1; Golgi sialoglycoprotein MG 160; Golgi sialoglycoprotein MG-160; GSLG1_HUMAN; MG 160; MG160; Mouse, homolog of, ESL1; Selel; Slectin, endothelial cell, ligand
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils).
  • 基因功能参考文献：
    1. Study identifies NRP2 and ESL-1 as targets for polysialylation in murine microglia and human THP-1 macrophages and reveals a striking convergence in the regulation of the two polysialylated acceptors in the course of inflammatory activation. A pool of polysialylated NRP2 and ESL-1 is assembled after injury or in culture and its shedding is an early response to lipopolysaccharide-induced activation of microglia. PMID: 27159043
    2. Our results highlight the fact that interaction between APN and ESL-1 could provide a fundamental mechanism underlying the anti-atherogenic properties of APN. PMID: 26792720
    3. circulating prostate cancer cells' rolling capacity contributes to metastasis, and that is in part controlled by ESL-1. PMID: 25301730
    4. Studies indicate that PSGL-1, CD44, and ESL-1 on mature leukocytes are physiologic glycoprotein ligands for endothelial P-selectin and E-selectin. PMID: 22021370
    5. expression of Cfr in the Golgi apparatus and on the plasma membrane is finely tuned through two distinct mechanisms for exhibiting different functions. PMID: 21777203
    6. C2GnT1 gene expression and the resulting C2-O-sLe(X) carbohydrates produced mediate the adhesive and invasive behaviors of human carcinomas which may influence their metastatic potential. PMID: 21283832
    7. evaluated in human brain tumors exhibiting varying degrees of malignancy PMID: 12684670
    8. a novel variant of the GLG1 gene product called GLG2 is reported; genetic analysis suggests GLG1 & GLG2 are the products of a single gene, the mRNA of which can be processed by alternative splicing to generate different transcripts encoding GLG1 or GLG2 PMID: 15797922
    9. under hypoxia, ESL-1 is shed from activated hepatic stellate cells PMID: 19148508

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  • 亚细胞定位：
    Golgi apparatus membrane; Single-pass type I membrane protein. Golgi outpost. Cytoplasm, cytoskeleton, microtubule organizing center.
  • 组织特异性：
    Widely expressed. Highest levels in pancreas, skeletal muscle, placenta, heart, testis and ovary. Also found in the kidney, liver, lung and brain.
  • 数据库链接：

    HGNC: 4316

    OMIM: 600753

    KEGG: hsa:2734

    STRING: 9606.ENSP00000205061

    UniGene: Hs.109731

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