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  4. Recombinant Human Glycerol-3-phosphate dehydrogenase [NAD (+)], Cytoplasmic domain (GPD1)

Recombinant Human Glycerol-3-phosphate dehydrogenase [NAD (+)], Cytoplasmic domain (GPD1)

  • 中文名称：
    人GPD1重组蛋白
  • 货号：
    CSB-EP009709HU
  • 规格：
    ￥1344
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    GPD1
  • Uniprot No.：
    P21695
  • 别名：
    AI747587; cytoplasmic; EC 1.1.1.8; FLJ26652; G3PD; Gdc-1; Gdc1; Gdp1; Glycerol 3 phosphate dehydrogenase 1; Glycerol 3 phosphate dehydrogenase cytosolic; Glycerol 3 phosphate dehydrogenase soluble; Glycerol-3-phosphate dehydrogenase [NAD+]; Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic; Glycerol-3-phosphate dehydrogenase 1 (soluble); Glycerol-3-phosphate dehydrogenase; Glycerol-3-phosphate dehydrogenase, soluble ; Glycerphosphate dehydrogenase; GPD-C; gpd1; Gpd1 protein; Gpd3; GPDA_HUMAN; Gpdc; GPDH; GPDH-C; Gpdhc; HTGTI; KIAA4010; MGC93453; MGPD; mKIAA4010
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length
  • 来源：
    E.coli
  • 分子量：
    53.6kDa
  • 表达区域：
    1-349aa
  • 氨基酸序列
    MASKKVCIVGSGNWGSAIAKIVGGNAAQLAQFDPRVTMWVFEEDIGGKKLTEIINTQHENVKYLPGHKLPPNVVAVPDVVQAAEDADILIFVVPHQFIGKICDQLKGHLKANATGISLIKGVDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVADEKFCETTIGCKDPAQGQLLKELMQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKLFCSGPVSSATFLESCGVADLITTCYGGRNRKVAEAFARTGKSIEQLEKELLNGQKLQGPETARELYSILQHKGLVDKFPLFMAVYKVCYEGQPVGEFIHCLQNHPEHM
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-SUMO-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

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GPD1 antibodies

GPD1 Proteins

靶点详情

  • 功能：
    Has glycerol-3-phosphate dehydrogenase activity.
  • 基因功能参考文献：
    1. To recognize this entity by considering GPD1 mutations in appropriate clinical settings. PMID: 27368975
    2. Although these data indicate that a lack of GPD1 inhibits gluconeogenesis from glycerol, chronic GPD1 deficiency may induce an adaptation that enhances gluconeogenesis from glycogenic amino acids PMID: 27733253
    3. The R269A mutation of GPDH1 results in a 110-fold increase in K(m) (2.8 kcal/mol effect) and a 41,000-fold decrease in k(cat) (6.3 kcal/mol effect), which corresponds to a 9.1 kcal/mol destabilization of the transition state. PMID: 25884759
    4. massive hepatomegaly, fatty liver and severe hypertriglyceridemia carrying a compound heterozygous mutation in GPD1 PMID: 24549054
    5. Mutation analysis revealed a homozygous splicing mutation, c.361-1G>C, which resulted in an aberrantly spliced mRNA in the ten affected individuals. PMID: 22226083
    6. The expression levels of the GPD1 gene did not differ between patients with OSA and their matched controls. The results were not affected by the clinical and biochemical measurements, the sleep parameters or the severity of nocturnal hypoxemia. PMID: 20404019
    7. Identification and function of mutations in FAD-binding domain of mitochonrial glycerophosphate dehydrogenase in caucasians with type 2 diabetes mellitus. PMID: 11822825
    8. GPD1 has a role in increased triacylglycerol production in adipose tissue of obese humans PMID: 14674682
    9. The apoenzyme structure of GPD1 has been determined; an electrophilic catalytic mechanism by the epsilon-NH3+ group of Lys204 is proposed on the basis of structural analyses. PMID: 16460752
    10. GpD1 is a weight-loss-responsive gene in skeletal muscle. Its observed transcriptional modulation may decrease triglyceride synthesis, with weight loss. PMID: 16849634
    11. The activities of glycerol phosphate dehydrogenase were decreased by 73% in pancreatic islets of patients with type 2 diabetes. PMID: 19296078
    12. the discovery overexpression of GPD1 and RRBP1 proteins and lack of expression for HNRNPH1 and SERPINB6 proteins which are new candidate biomarkers of colon cancer. PMID: 19425502

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  • 相关疾病：
    Hypertriglyceridemia, transient infantile (HTGTI)
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    NAD-dependent glycerol-3-phosphate dehydrogenase family
  • 组织特异性：
    Expressed in liver (at protein level).
  • 数据库链接：

    HGNC: 4455

    OMIM: 138420

    KEGG: hsa:2819

    STRING: 9606.ENSP00000301149

    UniGene: Hs.524418

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