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  4. Recombinant Human Glyceraldehyde-3-phosphate dehydrogenase, testis-specific (GAPDHS), partial

Recombinant Human Glyceraldehyde-3-phosphate dehydrogenase, testis-specific (GAPDHS), partial

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  • 中文名称：
    人GAPDHS重组蛋白
  • 货号：
    CSB-BP009254HU
  • 规格：
    ￥2832
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    GAPDHS
  • Uniprot No.：
    O14556
  • 别名：
    G3PT_HUMAN; GAPD2; GAPDH 2 ; GAPDH-2; GAPDH2; GAPDHS; GAPDS; Glyceraldehyde 3 phosphate dehydrogenase spermatogenic; Glyceraldehyde 3 phosphate dehydrogenase; testis specific; Glyceraldehyde-3-phosphate dehydrogenase; HSD 35; HSD35; Spermatogenic cell specific glyceraldehyde 3 phosphate dehydrogenase 2; Spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2; Spermatogenic glyceraldehyde 3 phosphate dehydrogenase; Spermatogenic glyceraldehyde-3-phosphate dehydrogenase; testis-specific
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 来源：
    Baculovirus
  • 分子量：
    39.1 kDa
  • 表达区域：
    69-408aa
  • 氨基酸序列
    MVSVARELTVGINGFGRIGRLVLRACMEKGVKVVAVNDPFIDPEYMVYMFKYDSTHGRYKGSVEFRNGQLVVDNHEISVYQCKEPKQIPWRAVGSPYVVESTGVYLSIQAASDHISAGAQRVVISAPSPDAPMFVMGVNENDYNPGSMNIVSNASCTTNCLAPLAKVIHERFGIVEGLMTTVHSYTATQKTVDGPSRKAWRDGRGAHQNIIPASTGAAKAVTKVIPELKGKLTGMAFRVPTPDVSVVDLTCRLAQPAPYSAIKEAVKAAAKGPMAGILAYTEDEVVSTDFLGDTHSSIFDAKAGIALNDNFVKLISWYDNEYGYSHRVVDLLRYMFSRDK
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

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GAPDHS antibodies

GAPDHS Proteins

靶点详情

  • 功能：
    May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility.
  • 基因功能参考文献：
    1. GAPDS overexpression antagonize high glucose-induced apoptosis by controlling reactive oxygen species accumulation in TM3 cells. PMID: 29626473
    2. It is assumed that the deficiency in GAPDS observed in most dysplasia of the fibrous sheath sperm samples is ascribable to a disorder in the regulation of GAPDS expression caused by the mutation in the intron region of GAPDS gene. PMID: 27135296
    3. This result implies that GAPDHS participates in specific signal-transduction pathways. PMID: 26660717
    4. Structural basis for the NAD binding cooperativity and catalytic characteristics of sperm-specific glyceraldehyde-3-phosphate dehydrogenase PMID: 25936797
    5. GAPDS protein was expressed in both Sertoli cells and elongated sperms. The expression of GAPDS gradually increased with age in the epididymis. PMID: 23306140
    6. Data indicate that the positive expression of studied genes fertilization rate for GAPDHS positive subset was 66%, ACR - 71%, SPATA22 - 68%, MND1 - 70%, pregnancy rates were 8%, 6%, 18% and 36% respectively. PMID: 23675907
    7. the expression of GAPDS in melanoma cells may facilitate glycolysis and prevent the induction of apoptosis. PMID: 23026046
    8. The chaperonin TRiC was shown to assist an ATP-dependent refolding of recombinant forms of GAPDS. PMID: 21995946
    9. Structure and kinetic characterization of human sperm-specific glyceraldehyde-3-phosphate dehydrogenase, GAPDS. PMID: 21269272
    10. Human his-GAPDHS expressed in baculovirus-infected insect cells is homotetrameric. PMID: 20828617
    11. Data suggest that high stability of the sperm-specific GAPDS is of importance for the efficiency of fertilization. PMID: 20833277
    12. We have concluded that a simple nuclear localization of GAPDH does not induce apoptosis, and that MPP+-induced apoptosis is not caused by nuclear translocation of GAPDH. PMID: 16324157
    13. Comparative study of the amino acid sequences of mammalian GAPDs revealed conservative cysteine residues (C21, C94, and C150) that are specific for the sperm isoenzyme and absent in the somatic isoenzyme. PMID: 18298375
    14. Characterization of the rat GAPDHS and comparison to the human and mouse enzymes. PMID: 16700075
    15. GAPD2 enzymatic activity is present in human sperm. GAPD2 is tightly bound to sperm and most enzymatic activity is not released by permeabilization with CHAPS detergent. GAPD2 is restricted in location to the principal piece of the sperm flagellum. PMID: 10714828

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Glyceraldehyde-3-phosphate dehydrogenase family
  • 组织特异性：
    Testis specific.
  • 数据库链接：

    HGNC: 24864

    OMIM: 609169

    KEGG: hsa:26330

    STRING: 9606.ENSP00000222286

    UniGene: Hs.248017

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