Recombinant Human Fibrinogen beta chain (FGB), partial Yeast

1. High fibrinogen expression is associated with esophageal carcinoma. PMID: 29134563
2. Compared with the patients with TT genotypes of fibrinogen beta, expressions of fibrinogen, IL-6 and CRP were significantly higher in the patients with the CC and CT genotypes. PMID: 29165755
3. Two novel fibrinogen Bbeta chain mutations in two Slovak families with hypofibrinogenemia/afibrinogenemia have been described. PMID: 29286337
4. FGB c.490G>A indicated the activation of a cryptic splice site causing the insertion of 99 bp in intron 3. This splicing abnormality led to the production of a Bbeta-chain possessing 33 aberrant amino acids, including two Cys residues in the coiled-coil domain. Therefore, a splicing abnormality may cause impaired fibrinogen assembly and secretion. PMID: 29156616
5. FGB mutations leading to congenital hypofibrinogenaemia PMID: 28306188
6. Fibrinogen Bbeta448Lys variant is associated with thrombotic fibrin clots in type 2 diabetic patients independently of traditional risk factors. PMID: 27929198
7. There was underexpression of the majority of genes after sunitinib treatment. The lower expression levels of IGFBP1, CCL20, CXCL6 and FGB were confirmed by qRT-PCR in all cases. The downregulation of gene expression leads us to search for methylation as a mechanism of action of the tyrosine kinase inhibitors PMID: 27834463
8. elevated levels of plasma homocysteine /homocysteine thiolactone contribute to AD pathology via the Abeta-fibrin(ogen) interaction PMID: 27090576
9. procoagulant changes in fibrin metastructure appear to result from excessive carbonylation of fibrinogen, which may compensate for a decrease in fibrinogen level in patients with cirrhosis PMID: 26833718
10. Prognostic impact of plasma fibrinogen levels in patients with esophageal squamous cell carcinoma PMID: 28064398
11. a tight cluster of alternating multiple splicing regulatory elements and U1 snRNA binding sites controls cryptic splice donor usage throughout the human fibrinogen Bbeta-chain gene (FGB) exon 7 PMID: 28039323
12. The plasma fibrinogen level was found to be a possible biomarker for clinical response to chemotherapy and postoperative metastasis or death in advanced breast cancer patients who received neoadjuvant chemotherapy PMID: 28621233
13. Data suggest that, in the binding of fibrin beta N-domains and the (1-8) peptide fragment of VLDLR (very low density lipoprotein receptor), the second and third Lys/Arg clusters in fibrin make major contributions to this interaction while the contribution of the first cluster is moderate. PMID: 28437098
14. The novel missense mutation in the FGB gene causes afibrinogenemia most probably by affecting the secretion of the fibrinogen beta-chain. PMID: 27824214
15. fibrinogen aggregation is accompanied by the formation of beta-sheet conformation, and induction of non-native helical segments in the protein inhibits aggregation PMID: 27150313
16. fibrinogen is an independent predictor of the angiographic presence of coronary artery disease in hypertensive patients. PMID: 27553289
17. novel mutation was identified in exon 2 of FGB caused by c.221G> T (dagger) substitution PMID: 27812779
18. Our results show that higher levels of circulating chemerin, CRP, fibrinogen, and ESR are associated with an increased risk of developing colorectal cancer PMID: 26628300
19. We assessed the diagnostic accuracy of a newly developed laboratory score-based on CA125, platelet count (PLT), C-reactive protein (CRP), and fibrinogen levels-in the preoperative diagnosis of adnexal mass PMID: 26499778
20. the mechanical properties of individual fibrin fibers formed from blood plasma, were examined. PMID: 27028649
21. Here we report a new B[beta] gene mutation (Fibrinogen St Kilda) identified in two Caucasian sisters with reduced fibrinogen level (1.2-1.6 g/L) during investigation for recurrent early miscarriages. PMID: 26308135
22. desAB fibrin binds to prothrombin through the Bbeta26-42 amino acid residues and the formation of such a complex causes a non-enzymatic activation of prothrombin PMID: 26317125
23. Strong positive association has been found between betatrophin, plasma fibrinogen (FBG), and insulin resistance in non-diabetic subjects. Correlations with FBG and insulin resistance were diminished in type 2 diabetes subjects. PMID: 26077345
24. These experiments demonstrate, for the FGB-p.Asp185Asn mutation, a pathogenic mechanism not common for fibrinogen deficiencies, i.e. the hyperglycosylation of the Bbeta chain due to the introduction of a novel N-glycosylation motif. PMID: 26006300
25. High plasma fibrinogen levels and platelet count are associated with esophageal squamous cell carcinoma. PMID: 25896470
26. Results suggest that FGB -148 C/T and -854 G/A polymorphisms probably contribute to susceptibility of ischemic stroke in Chinese population. PMID: 25890854
27. The results of the meta-analysis indicate that the -455 G>A polymorphism in the beta-fibrinogen gene is a susceptibility marker of ischemic cerebral infarction in the Chinese population. PMID: 25398500
28. In the present study, we found that the -148C>T polymorphism in the FGB gene was significantly associated with ischemic stroke in a Chinese population [meta-analysis] PMID: 25867317
29. This prospective study in 110 patients undergoing major cardiovascular surgery at risk of post-cardiopulmonary bypass bleeding compares fibrinogen level. PMID: 26011420
30. the NGR motif in fibrinogen is the site that is primarily responsible for the interaction with resting alphaIIbbeta3 and is responsible for triggering platelet activation PMID: 25413489
31. Elevated fibrinogen levels are associated with negative tumor response to therapy in rectal cancer. PMID: 25384698
32. Four novel FGB mutations were identified in two afibrinogenemic (one new-born and one 30 years old male) and hypofibrinogenemic (a 49 years old female) patient, with heterogeneous thrombotic and bleeding phenotype PMID: 24560896
33. plasma fibrinogen increase during ischemic stroke has a role in worse outcome PMID: 24531853
34. meta-analysis suggests that the FGB-455G/A polymorphism contributes to susceptibility to ischemic stroke and coronary heart disease PMID: 24448059
35. results of our meta-analysis suggested that the-148C>T polymorphism in the FGB gene is a susceptibility marker of ischemic stroke PMID: 24720800
36. The A + genotype of the FGB -455 G/A polymorphism associated with poor survival among 55-71 years old Caucasian women in the Finnish stroke cohort. PMID: 24957141
37. results indicate that FGbeta-455G/A polymorphism may be a susceptible predictor of ischemic stroke [meta-analysis] PMID: 24366241
38. Elevated fibrinogen is associated with idiopathic sudden hearing loss. PMID: 24466284
39. High fibrinogen levels are associated with gynecologic cancer. PMID: 25204086
40. Both fibrinogen polymorphisms are capable to modify the atherosclerotic process via their effects on the coagulation cascade. PMID: 23931975
41. The beta-fibrinogen -455G/A gene polymorphism is not a risk factor for ischaemic stroke in a Polish population. PMID: 23650004
42. A meta-analysis of a Chinese population found that the FgB -455G/A and the -148C/T gene polymorphism was implied to be associated with coronary artery disease susceptibility. PMID: 23129316
43. Both isoforms of the beta-chain of FIB discovered by 2D-gel electrophoresis are decreased in the Parkinson's disease group cerebrospinal fluid, compared to normal controls. PMID: 22889670
44. Lys, as an inhibitor of protein glycation, improved fibrinogen's structure and function, both in vitro and in vivo. PMID: 22575419
45. Fibrinogen polymorphisms contributes to the association between common variants in the fibrinogen gene and the risk of developing sporadic cerebral hemorrhage. PMID: 22386478
46. study found that -C148T FGB polymorphism was an independent predictor of pre- and early postoperative C-reactive protein levels in coronary artery bypass graft patients PMID: 21499712
47. genetic polymorphism is associated with plasma fibrinogen levels and haematological traits in whites, blacks and mexican americans PMID: 22273812
48. Levels of fibrinogen and thromboelastometry fibrin polymerisation following treatment with desmopressin (DDAVP). PMID: 22293628
49. The BF -455G/A polymorphisms was found to be positively. PMID: 21241403
50. Fibrinogen has chaperone activity which is compromised upon glycation by methylglyoxal. PMID: 22053176

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HGNC: 3662

OMIM: 134830

KEGG: hsa:2244

STRING: 9606.ENSP00000306099

UniGene: Hs.300774