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  4. Recombinant Human FERM domain-containing protein 4A (FRMD4A), partial

Recombinant Human FERM domain-containing protein 4A (FRMD4A), partial

  • 中文名称：
    人FRMD4A重组蛋白
  • 货号：
    CSB-YP873739HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人FRMD4A重组蛋白
  • 货号：
    CSB-EP873739HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人FRMD4A重组蛋白
  • 货号：
    CSB-EP873739HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人FRMD4A重组蛋白
  • 货号：
    CSB-BP873739HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人FRMD4A重组蛋白
  • 货号：
    CSB-MP873739HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    FRMD4A
  • Uniprot No.：
    Q9P2Q2
  • 别名：
    FRMD4A; FRMD4; KIAA1294FERM domain-containing protein 4A
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4B in epithelial polarization. May regulate MAPT secretion by activating ARF6-signaling.
  • 基因功能参考文献：
    1. FRMD4A RNAi or inhibition of cytohesins strongly upregulated secretion of endogenous tau. These results suggest that FRMD4A, a genetic risk factor for late-onset Alzheimer's disease, regulates tau secretion by activating cytohesin-Arf6 signaling. PMID: 27044754
    2. Findings suggest that FRMD4A expression correlates with the development of tongue squamous cell carcinoma. PMID: 27666346
    3. novel microcephaly, intellectual disability and dysmorphism syndrome is associated with a mutation in FRMD4A. PMID: 25388005
    4. data suggest that FRMD4A could be a relevant candidate gene for AD risk. PMID: 22430674
    5. findings suggest FRMD4A as a novel candidate therapeutic target in HNSCC based on the key role in metastatic growth we have identified PMID: 22564525
    6. A single nucleotide polymorphism in the FERM domain containing 4A protein is associated with nicotine dependence. PMID: 22006218

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  • 相关疾病：
    Agenesis of the corpus callosum, with facial anomalies and cerebellar ataxia (CCAFCA)
  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction, tight junction.
  • 数据库链接：

    HGNC: 25491

    OMIM: 616305

    KEGG: hsa:55691

    STRING: 9606.ENSP00000350032

    UniGene: Hs.330463

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