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  4. Recombinant Human FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1), partial

Recombinant Human FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1), partial

  • 中文名称：
    人FOXRED1重组蛋白
  • 货号：
    CSB-YP822192HU1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人FOXRED1重组蛋白
  • 货号：
    CSB-EP822192HU1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人FOXRED1重组蛋白
  • 货号：
    CSB-EP822192HU1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人FOXRED1重组蛋白
  • 货号：
    CSB-BP822192HU1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人FOXRED1重组蛋白
  • 货号：
    CSB-MP822192HU1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    FOXRED1
  • Uniprot No.：
    Q96CU9
  • 别名：
    FOXRED1; FP634; FAD-dependent oxidoreductase domain-containing protein 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

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FOXRED1 antibodies

FOXRED1 Proteins

靶点详情

  • 功能：
    Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late stages of complex I assembly.
  • 基因功能参考文献：
    1. Results show that depletion of FOXRED1 in myoblasts results in decreased levels of fully assembled complexes I and II. FOXRED1 associates with the ND1-containing subcomplexes of ~370 kDa and ~620 kDa and that FOXRED1 activity is required for the formation of a 550-kDa subcomplex of complex I. PMID: 27215383
    2. Loss of FOXRED1, coupled with protein, choline and/or folate-deficient diets results in the depletion of glutathione, the dysregulation of nitric oxide metabolism and the peroxynitrite-mediated inactivation of complex I. PMID: 26235939
    3. A structural model of FOXRED1 reveals a large substrate-binding cavity and a putative oxygen-binding site. PMID: 25765152
    4. FOXRED1 is a crucial component in the productive assembly of respiratory chain complex I and that mutations in FOXRED1 leading to partial loss of function cause defects in complex I biogenesis. PMID: 25678554
    5. Mutations in FOXRED1 are associated with complex I deficiency. PMID: 20818383

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  • 相关疾病：
    Mitochondrial complex I deficiency (MT-C1D)
  • 亚细胞定位：
    Mitochondrion inner membrane; Single-pass membrane protein.
  • 数据库链接：

    HGNC: 26927

    OMIM: 252010

    KEGG: hsa:55572

    STRING: 9606.ENSP00000263578

    UniGene: Hs.317190

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