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  4. Recombinant Human Exocyst complex component 3 (EXOC3)

Recombinant Human Exocyst complex component 3 (EXOC3)

  • 中文名称：
    人EXOC3重组蛋白
  • 货号：
    CSB-YP527663HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人EXOC3重组蛋白
  • 货号：
    CSB-EP527663HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人EXOC3重组蛋白
  • 货号：
    CSB-EP527663HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人EXOC3重组蛋白
  • 货号：
    CSB-BP527663HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人EXOC3重组蛋白
  • 货号：
    CSB-MP527663HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    EXOC3
  • Uniprot No.：
    O60645
  • 别名：
    EXOC 3; Exoc3; EXOC3_HUMAN; Exocyst complex component 3; Exocyst complex component Sec 6; Exocyst complex component Sec6; rSec 6; Sec 6; Sec 6 homolog; Sec 6p; Sec6; SEC6 L1; SEC6 like 1; Sec6 protein; SEC6L1; Sec6p
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-756
  • 氨基酸序列
    MQCEDSTSFF TMKETDREAV ATAVQRVAGM LQRPDQLDKV EQYRRREARK KASVEARLKA AIQSQLDGVR TGLSQLHNAL NDVKDIQQSL ADVSKDWRQS INTIESLKDV KDAVVQHSQL AAAVENLKNI FSVPEIVRET QDLIEQGALL QAHRKLMDLE CSRDGLMYEQ YRMDSGNTRD MTLIHGYFGS TQGLSDELAK QLWMVLQRSL VTVRRDPTLL VSVVRIIERE EKIDRRILDR KKQTGFVPPG RPKNWKEKMF TILERTVTTR IEGTQADTRE SDKMWLVRHL EIIRKYVLDD LIVAKNLMVQ CFPPHYEIFK NLLNMYHQAL STRMQDLASE DLEANEIVSL LTWVLNTYTS TEMMRNVELA PEVDVGTLEP LLSPHVVSEL LDTYMSTLTS NIIAWLRKAL ETDKKDWVKE TEPEADQDGY YQTTLPAIVF QMFEQNLQVA AQISEDLKTK VLVLCLQQMN SFLSRYKDEA QLYKEEHLRN RQHPHCYVQY MIAIINNCQT FKESIVSLKR KYLKNEVEEG VSPSQPSMDG ILDAIAKEGC SGLLEEVFLD LEQHLNELMT KKWLLGSNAV DIICVTVEDY FNDFAKIKKP YKKRMTAEAH RRVVVEYLRA VMQKRISFRS PEERKEGAEK MVREAEQLRF LFRKLASGFG EDVDGYCDTI VAVAEVIKLT DPSLLYLEVS TLVSKYPDIR DDHIGALLAV RGDASRDMKQ TIMETLEQGP AQASPSYVPL FKDIVVPSLN VAKLLK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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EXOC3 antibodies

靶点详情

  • 功能：
    Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
  • 基因功能参考文献：
    1. Sec6 regulate Bcl-2 and Mcl-1 expressions but not Bcl-xl in malignant peripheral nerve sheath tumor cells. PMID: 26892009
    2. Sec6 regulates NF-kappaB transcriptional activity via the control of the phosphorylation of IkappaBalpha, p90RSK1, and ERK PMID: 26247921
    3. The study explores the role of the exocyst complex component Sec6/8 in genomic stability. PMID: 26283729
    4. Sec6 regulates cytoplasmic translocation of p27 through p27 phosphorylation at Thr157, thereby promoting p27 degradation in the cytoplasm via interaction with Jab1 and Siah1 and suppressing cell cycle progression. PMID: 24949832
    5. Data demonstrate that the expression of alpha-E-catenin is increased by Sec6 siRNAs, and E-cadherin and beta-catenin localize mainly at the cell-cell contact region in HSC3 cells, which were transfected with Sec6 siRNA. PMID: 22381337

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone. Midbody. Golgi apparatus. Cell projection, neuron projection.
  • 蛋白家族：
    SEC6 family
  • 组织特异性：
    Expressed in epididymis (at protein level).
  • 数据库链接：

    HGNC: 30378

    OMIM: 608186

    KEGG: hsa:11336

    STRING: 9606.ENSP00000323377

    UniGene: Hs.481464

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