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  4. Recombinant Human Espin (ESPN), partial

Recombinant Human Espin (ESPN), partial

  • 中文名称：
    人ESPN重组蛋白
  • 货号：
    CSB-YP007827HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人ESPN重组蛋白
  • 货号：
    CSB-EP007827HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人ESPN重组蛋白
  • 货号：
    CSB-EP007827HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人ESPN重组蛋白
  • 货号：
    CSB-BP007827HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人ESPN重组蛋白
  • 货号：
    CSB-MP007827HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ESPN
  • Uniprot No.：
    B1AK53
  • 别名：
    ESPN; DFNB36; LP2654Espin; Autosomal recessive deafness type 36 protein; Ectoplasmic specialization protein
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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ESPN antibodies

靶点详情

  • 功能：
    Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells. Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia. Involved in the elongation of actin in stereocilia. In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircase formation.
  • 基因功能参考文献：
    1. A significant inverse correlation was observed between miR-612 and Espin protein expression in melanoma tissues. PMID: 29385671
    2. The utricles were then treated with a gamma-secretase inhibitor, followed by espin or control transduction and histochemistry. Although gamma-secretase inhibition increased the number of HCs, few had stereociliary arrays. In contrast, 46 h after espin1 transduction, a significant increase in hair-bundle-like structures was observed PMID: 26886463
    3. The espin actin-filament-binding site has a major effect on the formation and dynamics of actin bundles. PMID: 24424026
    4. human deafness and vestibular dysfunction co-segregated with either of two frameshift mutations in ESPN. PMID: 15286153
    5. The results further strengthen the causative role of the espin gene in non-syndromic hearing loss and add new insights into espin structure and function. PMID: 15930085
    6. Here, we report a new activity of the espins, one that depends on their enigmatic WH2 domain: the ability to assemble a large actin bundle when targeted to a specific subcellular location. PMID: 16569662
    7. A recessive ESPN mutation causing congenital hearing loss in a Morocan family was reported. PMID: 18973245
    8. Flies with mutations affecting the diaphanous,forked, and CG12026/TMHS genes displayed significant reductions in the amplitude of sound-evoked potentials compared to wild-type flies PMID: 19102128

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  • 相关疾病：
    Deafness, autosomal recessive, 36, with or without vestibular involvement (DFNB36)
  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cell projection, stereocilium. Cell projection, microvillus.
  • 数据库链接：

    HGNC: 13281

    OMIM: 606351

    KEGG: hsa:83715

    STRING: 9606.ENSP00000367059

    UniGene: Hs.744222

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