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  4. Recombinant Human Envoplakin (EVPL), partial

Recombinant Human Envoplakin (EVPL), partial

  • 中文名称：
    人EVPL重组蛋白
  • 货号：
    CSB-YP007870HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人EVPL重组蛋白
  • 货号：
    CSB-EP007870HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人EVPL重组蛋白
  • 货号：
    CSB-EP007870HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人EVPL重组蛋白
  • 货号：
    CSB-BP007870HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人EVPL重组蛋白
  • 货号：
    CSB-MP007870HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    EVPL
  • Uniprot No.：
    Q92817
  • 别名：
    EVPLEnvoplakin; 210 kDa cornified envelope precursor protein; 210 kDa paraneoplastic pemphigus antigen; p210
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments.
  • 基因功能参考文献：
    1. N-terminus extremities of envoplakin and C-terminus of its linker subdomain are major epitopes of paraneoplastic pemphigus PMID: 27427435
    2. We confirmed associations with papillary thyroid cancer and SNPs in FOXE1/HEMGN, SERPINA5 (rs2069974), FTO (rs8047395), EVPL (rs2071194), TICAM1 (rs8120) and SCARB1 (rs11057820) genes. We found associations with SNPs in FOXE1, SERPINA5, FTO, TICAM1 and HSPA6 and and follicular thyroid cancer PMID: 27207655
    3. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration. PMID: 22360420
    4. autoantibodies are detected in patients with paraneoplastic pemphigus PMID: 18820940
    5. envoplakin and periplakin bind to the plasma membrane upon elevation of intracellular [Ca(2+)] in differentiating keratinocytes, where they serve as a scaffold for cornified cell envelope assembly PMID: 15033990
    6. EVPL might not be the target gene responsible for oesophageal cancer, despite its strong candidacy in terms of character and localization PMID: 15756445

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  • 亚细胞定位：
    Cell junction, desmosome. Cornified envelope. Cytoplasm, cytoskeleton. Note=Colocalized with DSP at desmosomes and along intermediate filaments.
  • 蛋白家族：
    Plakin or cytolinker family
  • 组织特异性：
    Exclusively expressed in stratified squamous epithelia.
  • 数据库链接：

    HGNC: 3503

    OMIM: 601590

    KEGG: hsa:2125

    STRING: 9606.ENSP00000301607

    UniGene: Hs.500635

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