Recombinant Human Endoribonuclease Dicer (DICER1), partial

1. The DICER mediates the recruitment of the methyltransferase MMSET to the DNA damage site. PMID: 29233865
2. DICER1 is a driver of pediatric thyroid nodules, and DICER1-mutated papillary thyroid carcinoma may represent a distinct class of low-risk malignancies. PMID: 29474644
3. Testing for DICER1 mutations may be beneficial for distinguishing between ovarian Sertoli-Leydig cell tumors subtypes and from other tumors in the ovarian sex cord-stromal tumors category, as well as other primary tumors of the ovary PMID: 30072170
4. DICER rs3742330 AG+GG genotype was associated with more advanced T stage compared to AA genotype ( P=0.009). More patients with XPO5 rs2257082 CC genotype had poorly differentiated tumors compared with CT+TT genotype carriers..), carriers of RAN rs14035 CC genotype had higher three-year OS rate than carriers of CT+TT genotype (adjusted HR 3.174; 95% CI 1.010, 9.973; P=0.048). PMID: 29683064
5. DICER1 hot-spot mutation is the key-driving event in a subset of gynandroblastomas containing components of Sertoli-Leydig cell tumour and juvenile granulosa cell tumour PMID: 29660837
6. We tested the role of microRNAs in hepatic stellate cells by hepatic stellate cell-specific Dicer deletion. Although Dicer deletion decreased microRNA expression in hepatic stellar cells and altered the expression of select genes, it only exerted negligible effects on hepatic stellate cells activation and liver fibrosis PMID: 29091291
7. Data indicate that Dicer protein was specifically overexpressed in ovarian tumor stroma PMID: 29199004
8. Different genotypes frequency of DICER1 (rs12323635, rs1057035, rs13078 and rs3742330) were determined by sequencing method in 385 infertile men and 120 fertile controls. It was found that CC genotype (P = 0.000) and C allele (P = 0.0) of rs1057035 T > C polymorphism were associated with idiopathic male infertility (azoospermia). PMID: 29892896
9. DICER1-AS1 regulates the proliferation, invasion and autophagy of osteosarcoma via miR-30b/ATG5 axis. PMID: 29772430
10. neither likely pathogenic nor pathogenic variants in DICER1 appear to play a major role in transposition of the great arteries. PMID: 29399970
11. first report of DICER1 mutations in pulmonary blastoma. PMID: 27126690
12. Decreased argonaute 2 and dicer1 in peripheral blood mononuclear cells from War Veterans with post-traumatic stress disorder leads to diminished miRNA resulting in elevated inflammation. PMID: 28850112
13. The activation of Dicer suppressed the production of TNFalpha. These results suggested that Dicer can balance the production of TNFalpha, and thus may serve as a regulator of the immune response in patients with RA. PMID: 28627619
14. Dicer efficiently suppresses the replication of adenovirus via cleavage of adenovirus-encoding small RNAs. PMID: 27273616
15. The present study demonstrates that hypoxia-induced downregulation of Dicer serves as key mechanism in the maintenance of the hypoxic response in HCC and that prevention of hypoxic suppression of Dicer not only alleviates hypoxia-induced upregulation of HIF1a and HIF2a and other key hypoxia-responsive/HIF target genes, but also inhibits hypoxia-induced metastatic phenotypes such as EMT and increased cell motility. PMID: 28167508
16. two cases with DICER1 mutations were found to have lung cysts preceding the diagnosis of pathogenesis of pleuropulmonary blastoma PMID: 28624956
17. Decreased Dicer expression was found in chronic lymphocytic leukemia patients with chromosomal deletions. PMID: 28388279
18. Most neoplasms in the syndrome have been shown to harbor biallelic pathogenic variants in DICER1, usually a germline loss-of-function pathogenic variant in one allele that can occur in any domain and a tumor-specific pathogenic somatic variant in exons encoding the RNase IIIb domain of the second allele PMID: 28620008
19. Describe familial HCC associated with a novel DICER1 germline mutation and altered liver zonation. Familial and sporadic HCCs carrying DICER1 mutations are associated with CTNNB1 mutation and characterized by a reduced expression of specific mature miRNAs. PMID: 28012864
20. Findings imply that Dicer inhibits clear cell renal cell carcinoma (ccRCC) metastasis and may serve as promising prognostic biomarkers for ccRCC patients. PMID: 27732931
21. Our results suggest that, in contrast to FOXL2 mutations in adult granulosa cell tumours (A-GCTs), DICER1 mutations in Sertoli-Leydig cell tumours (SLCTs) might be more useful for prognosis than for diagnosis. PMID: 26033501
22. Low Dicer status was associated with poor prognosis in ovarian cancer, otorhinolaryngological tumors and ematological malignancies. PMID: 27682871
23. Study identified nonsense germ-line and missense somatic mutations in DICER1 causing a truncated protein at the IIIb domain level that segregate within a family affected with Dicer1 syndrome. PMID: 28222777
24. Data suggest that DICER plays a pleiotropic role in glioma stem-like cells, modulating the growth properties of glioma tumors arising from these cells and their response to DNA damage-inducing agents, leading to formation of larger tumors that are more sensitive to radiation. PMID: 27421140
25. validate the results of the aforementioned animal study and demonstrate downregulation of DICER1 gene and abnormal miRNA profile in myelodysplastic syndrome PMID: 29102598
26. We found that inhibition of DICER processing of miR-544 through the use of a small molecule abolished miR-544 function in regulating adaptation of breast cancer cells to hypoxic stress. PMID: 27924483
27. Data show that the expression of miRNAs and Dicer1 were downregulated in cells lines expressing HTLV-I HBZ protein (HBZ) as well as in fresh CD4 (+) cells from acute adult T cell Leukemia (ATL) patients. PMID: 26849145
28. the DICER rs1057035 TT genotype and DROSHA rs644236 CC genotype were associated with the development of GD and the differentiation between GD and HD, respectively. The expression levels of DICER and DROSHA genes were low in AITD and differed depending on the intractability of GD and the severity of HD, respectively. PMID: 27808570
29. Data indicate that Dicer1 can function as a traditional loss-of-function tumor suppressor gene. PMID: 28916654
30. For the first time, we establish macrocephaly as a common finding in the DICER1 syndrome. Like some other tumor-predisposition disorders, macrocephaly may be a useful, albeit a subtle, clinical clue to the DICER1 syndrome diagnosis PMID: 27441995
31. The increased miR-122 levels were associated with poor metastasis-free survival in ccRCC patients with localized disease. Dicer was validated as a direct functional target of miR-122. Overexpression of miR-122 promoted migration and invasion of ccRCC cells in vitro and metastatic behavior of ccRCC cells in vivo. PMID: 28921581
32. Nearly all (36/37) SLCTs and 4/4 GAB tested had a DICER1 mutation in an RNase IIIb domain hotspot; approximately half of these individuals had a predisposing germline DICER1 mutation. PMID: 29037807
33. This DICER1 mutant allele (G803R) was reduced to homozygosity. PMID: 26566882
34. BRG1 and SMARCAL1, members of the ATP-dependent chromatin remodelling family, are shown to co-regulate the transcription of DROSHA, DGCR8, and DICER in response to double-strand DNA breaks. PMID: 28716689
35. Meta-analysis revealed an increase in CTNNB1 and a decrease in DICER1 expression levels in the high-risk group. These results uncover beta-catenin as a critical factor in promoting ovarian cancer aggressiveness and a new mechanism linking between beta-catenin and miRNA downregulation underlying this process PMID: 28650464
36. The expression of Dicer negatively correlated with that of SFRP1 and it appeared to promote CCA cell proliferation. PMID: 28230864
37. DICER1 pathogenic variation is associated with pleuropulmonary blastoma, cystic nephroma and Sertoli-Leydig cell tumor. PMID: 28748527
38. Next-Gen sequencing for DICER1 mutations of their family revealed that both twins and their mother had c.C3675A mutation. PMID: 28688118
39. a possible interaction of the mismatch repair system with DICER1 to cause corpus callosum agenesis PMID: 28562508
40. Our case also emphasizes the need for testing for DICER1 mutations in pediatric patients with ovarian SLCTs. PMID: 28502826
41. these findings revealed a function of Dicer in NHEJ-mediated DSB repair and the association of Dicer expression with chemoresistance in colon cancer patients. PMID: 28911000
42. Despite exhibiting an immunophenotype characteristic of a sex cord-stromal tumor, mutations in FOXL2 and DICER1, the 2 most common mutations hitherto reported in ovarian sex cord-stromal tumors, are not a feature of Uterine tumor resembling ovarian sex cord tumor (UTROSCT). PMID: 26598979
43. Place Dicer within the context of the DNA damage response by demonstrating a DNA damage-inducible phosphoswitch that causes localized processing of nuclear dsRNA by p-Dicer to promote DNA repair. PMID: 28642363
44. In response to UV irradiation, DICER is recruited to chromatin in a ZRF1-mediated manner. The H2A-ubiquitin binding protein ZRF1 and DICER together impact on the chromatin conformation via PARP1. PMID: 28402505
45. We investigated the frequency of DICER1 mutations in a series of 38 ovarian tumors initially diagnosed as Sertoli-Leydig cell tumors, and explored whether identified mutations were associated with specific morphologic features PMID: 28654427
46. Case Report: metachronous anaplastic sarcoma of the kidney and thyroid follicular carcinoma with DICER1 mutations. PMID: 27697588
47. Dicer expression in smooth muscle cells plays an essential role in vascular repair by generating anti-proliferative miRNAs. PMID: 27622243
48. a clear mechanistic link between hypoxia and tumor progression via upregulation of miR-630 and downregulation of Dicer. PMID: 26725326
49. DICER1 hotspot mutations are closely associated with androgenic effects in ovarian Sertoli-Leydig cell tumors. PMID: 27664536
50. We show that deleterious DICER1 mutations underlie the genetic basis of only a small fraction of sarcomas, in particular rhabdomyosarcoma of the urogenital tract. PMID: 28524158

显示更多

收起更多

HGNC: 17098

OMIM: 138800

KEGG: hsa:23405

STRING: 9606.ENSP00000343745

UniGene: Hs.738957