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  4. Recombinant Human Ecotropic viral integration site 5 protein homolog (EVI5), partial

Recombinant Human Ecotropic viral integration site 5 protein homolog (EVI5), partial

  • 中文名称：
    人EVI5重组蛋白
  • 货号：
    CSB-YP007867HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人EVI5重组蛋白
  • 货号：
    CSB-EP007867HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人EVI5重组蛋白
  • 货号：
    CSB-EP007867HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人EVI5重组蛋白
  • 货号：
    CSB-BP007867HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人EVI5重组蛋白
  • 货号：
    CSB-MP007867HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    EVI5
  • Uniprot No.：
    O60447
  • 别名：
    EVI5; NB4SEcotropic viral integration site 5 protein homolog; EVI-5; Neuroblastoma stage 4S gene protein
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis.
  • 基因功能参考文献：
    1. The allele and genotype frequencies of rs6680578 and rs11810217 were not significantly different between relapsing-remitting multiple sclerosis (MS) cases and controls. However, in the rs10735781 the GG genotype was significantly associated with MS risk in recessive and co-dominant models. T G T haplotype (rs6680578, rs10735781 and rs11810217 respectively) was associated with MS risk. PMID: 29141798
    2. EVI5 is an useful independent prognostic marker of survival and recurrence in hepatocellular carcinoma PMID: 28765910
    3. EVI5 as a strong candidate disease risk gene in the 1p22.1 multiple sclerosis risk locus PMID: 26433934
    4. Data show that heat shock transcription factor 1/miR-135b/reversion-inducing-cysteine-rich protein with kazal motifs and ecotropic viral integration site 5 axis provides novel insight into the mechanisms of hepatocellular carcinoma metastasis. PMID: 25537516
    5. in HLA-DRB1 positive patients, EVI5 was associated with attacks of greater severity and worse recovery in Multiple sclerosis . PMID: 24130709
    6. cellular functions exhibited by the Evi5 family members PMID: 23669355
    7. An analysis and fine mapping of GFI-EVI5-RPL5-FAM69A locus, genotyping eight Tag-single nucleotide polymorphisms in 732 multiple sclerosis patients and 974 controls from Spain, was performed. PMID: 20087403
    8. Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis. PMID: 20008790
    9. a novel centrosomal protein with a complex expression pattern and subcellular localization, possibly involved in centrosome stability and dynamics PMID: 16033705
    10. Data provide evidence that EVI5 is an essential component of the protein machinery facilitating the final stages of cell septation at the end of mitosis. PMID: 16764853
    11. Evi5 is a Rab11 binding protein and that Evi5 may cooperate with Rab11 to coordinate vesicular trafficking, cytokinesis, and cell cycle control independent of GTPase-activating protein function PMID: 17229837
    12. EVI5 is a risk gene for multiple sclerosis. PMID: 18401352

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  • 相关疾病：
    A chromosomal aberration involving EVI5 is found is a patient with stage 4S neuroblastoma. Translocation t(1;10)(p22;q21) that forms a EVI5-TRNG10 fusion protein. TRNG10 is a probable structural transcript which is normally not translated.
  • 亚细胞定位：
    Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associates with the mitotic spindle through anaphase and remains within the midzone and midbody until completion of cytokinesis.
  • 组织特异性：
    Expressed in various cell lines (at protein level). Expressed in a wide range of tissues including brain and adrenal.
  • 数据库链接：

    HGNC: 3501

    OMIM: 602942

    KEGG: hsa:7813

    STRING: 9606.ENSP00000359356

    UniGene: Hs.594434

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