Recombinant Human ER degradation-enhancing alpha-mannosidase-like 3 (EDEM3), partial

中文名称：

人EDEM3重组蛋白
货号：

CSB-YP863170HU
规格：
来源：

Yeast
其他：

中文名称：

人EDEM3重组蛋白
货号：

CSB-EP863170HU
规格：
来源：

E.coli
其他：

中文名称：

人EDEM3重组蛋白
货号：

CSB-EP863170HU-B
规格：
来源：

E.coli
共轭：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名称：

人EDEM3重组蛋白
货号：

CSB-BP863170HU
规格：
来源：

Baculovirus
其他：

中文名称：

人EDEM3重组蛋白
货号：

CSB-MP863170HU
规格：
来源：

Mammalian cell
其他：

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纯度：

>85% (SDS-PAGE)
基因名：

EDEM3
Uniprot No.：

Q9BZQ6
别名：

alpha-1,2-mannosidase EDEM3; C1orf22; EDEM 3; edem3; EDEM3_HUMAN; ER degradation enhancer; mannosidase alpha like 3; ER degradation enhancing alpha mannosidase like 3; ER degradation enhancing alpha mannosidase like protein 3; ER degradation-enhancing alpha-mannosidase-like 3
种属：

Homo sapiens (Human)
蛋白长度：

Partial
蛋白标签：

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
产品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
复溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
储存条件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保质期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
货期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事项：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

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功能：

Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans. Seems to have alpha 1,2-mannosidase activity.
基因功能参考文献：
1. The data corroborated herein suggest that besides ER residents, EDEM3 interacts also with proteins involved in the ERAD cargo recognition and targeting to degradation translocation into the cytosol, including UBA1 and UBA2 ubiquitinating enzymes. In addition, the results indicate that this network of EDEM3 interactors is highly sensitive to interfering with early ER N-glycan processing. PMID: 28366632
亚细胞定位：

Endoplasmic reticulum lumen.
蛋白家族：

Glycosyl hydrolase 47 family
数据库链接：

HGNC: 16787

OMIM: 610214

KEGG: hsa:80267

STRING: 9606.ENSP00000318147

UniGene: Hs.523811

Recombinant Human ER degradation-enhancing alpha-mannosidase-like 3 (EDEM3), partial

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