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  4. Recombinant Human E3 ubiquitin-protein ligase UBR4 (UBR4), partial

Recombinant Human E3 ubiquitin-protein ligase UBR4 (UBR4), partial

  • 中文名称：
    人UBR4重组蛋白
  • 货号：
    CSB-YP725568HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人UBR4重组蛋白
  • 货号：
    CSB-EP725568HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人UBR4重组蛋白
  • 货号：
    CSB-EP725568HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人UBR4重组蛋白
  • 货号：
    CSB-BP725568HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人UBR4重组蛋白
  • 货号：
    CSB-MP725568HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    UBR4
  • Uniprot No.：
    Q5T4S7
  • 别名：
    600 kDa retinoblastoma protein associated factor; 600 kDa retinoblastoma protein-associated factor; E3 ubiquitin-protein ligase UBR4; KIAA0462; KIAA1307; N-recognin-4; p600; RBAF600; Retinoblastoma associated factor 600 like protein; Retinoblastoma associated factor of 600 kDa; Retinoblastoma-associated factor 600; Retinoblastoma-associated factor of 600 kDa; Ubiquitin protein ligase E3 component n recognin 4; UBR4; UBR4_HUMAN; Zinc finger UBR1 type protein 1; Zinc finger UBR1-type protein 1; Zinc finger, UBR1 type 1; ZUBR 1; ZUBR1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.
  • 基因功能参考文献：
    1. Ubiquitin ligase Ubr4 is a key component of the podocin interactome purified from podocytes. Ubiquitylation of one podocin site, K301, do not only target podocin for proteasomal degradation, but may also affect stability and disassembly of the multimeric complex. PMID: 26792178
    2. Results showed KCMF1 C-terminus binds directly to RAD6, whereas N-terminal domains interact with UBR4 and point mutations found in X-linked intellectual disability (XLID) patients specifically lose the interaction with KCMF1 and UBR4. PMID: 25582440
    3. This review summarizes the central nervous system functions of p600 and proposes new perspectives on its biological complexity in neuronal physiology and neurological diseases. PMID: 25424645
    4. Although UBR4 is not an ion channel gene, the potential for disrupted Ca(2+) control within neuronal cells highlights its potential for a role in this form of episodic ataxia. PMID: 23982692
    5. Dengue virus co-opts UBR4 to degrade STAT2 and antagonize type I interferon signaling. PMID: 23555265
    6. p600 is a cellular target of the human papillomavirus type 16 E7 oncoprotein that regulates cellular pathways that contribute to anchorage-independent growth and cellular transformation. PMID: 16061792
    7. Results identify and characterize p600, a unique 600-kDa retinoblastoma protein- and calmodulin-binding protein. PMID: 16214886
    8. Human papillomavirus E7 oncoprotein associates with p600; interaction strongly contributes to cellular transformation independent of ability of E7 to bind pRB. PMID: 16061792

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein. Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Concentrates at the leading edge of membrane structures involved in actin motility.
  • 蛋白家族：
    UBR4 family
  • 数据库链接：

    HGNC: 30313

    OMIM: 609890

    KEGG: hsa:23352

    STRING: 9606.ENSP00000364403

    UniGene: Hs.148078

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