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  4. Recombinant Human E3 ubiquitin-protein ligase RNF216 (RNF216), partial

Recombinant Human E3 ubiquitin-protein ligase RNF216 (RNF216), partial

  • 中文名称：
    人RNF216重组蛋白
  • 货号：
    CSB-YP865157HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人RNF216重组蛋白
  • 货号：
    CSB-EP865157HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人RNF216重组蛋白
  • 货号：
    CSB-EP865157HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人RNF216重组蛋白
  • 货号：
    CSB-BP865157HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人RNF216重组蛋白
  • 货号：
    CSB-MP865157HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RNF216
  • Uniprot No.：
    Q9NWF9
  • 别名：
    RNF216; TRIAD3; UBCE7IP1; ZIN; E3 ubiquitin-protein ligase RNF216; EC 2.3.2.27; RING finger protein 216; RING-type E3 ubiquitin transferase RNF216; Triad domain-containing protein 3; Ubiquitin-conjugating enzyme 7-interacting protein 1; Zinc finger protein inhibiting NF-kappa-B
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down-regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Isoform 3 inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis.
  • 基因功能参考文献：
    1. RNF216 is a potential biomarker and novel therapeutic target for inhibiting colorectal carcinoma development and progression. PMID: 27203674
    2. missense mutations in TRIAD3 abolished the interaction of TRIAD3A with Arc, disrupting Arc ubiquitination, and consequently Arc degradation. PMID: 27995769
    3. Novel RNF216 mutations causing an Huntington-like phenotype with pure monogenic recessive inheritance. . PMID: 25841028
    4. Loss of Triad3A mimics and occludes Arc-dependent forms of synaptic plasticity. PMID: 24945773
    5. The syndrome of hypogonadotropic hypogonadism, ataxia, and dementia can be caused by inactivating mutations in RNF216 or by the combination of mutations in RNF216 and OTUD4. PMID: 23656588
    6. By promoting polyubiquitylation and degradation, E3 ubiquitin ligase Triad3A is identified as an interaction partner for the killer cell Ig-like receptor KIR2DL4 cytoplasmic domain. PMID: 21270397
    7. Triad3A represents a versatile E3 ubiquitin ligase that negatively regulates RIG-like receptor signaling by targeting TRAF3 for degradation following RNA virus infection. PMID: 19893624
    8. interacts with RIP and inhibits tnf and il1-induced NFKB activation PMID: 11854271
    9. ZIN binds to purified Vif in vitro and Triad 3/ZIN interacts with HIV-1 Vif in transfected human 293T cells, as demonstrated by coimmunoprecipitation PMID: 15367624
    10. Triad3A regulates ubiquitination and proteasomal degradation of RIP1 following disruption of Hsp90 binding and play a crucial role in innate immunity PMID: 16968706
    11. Gene expression of RIPK3 and RNF216 in PBMC could identify those obese subjects, who will regain more weight after a successful initial weight loss. The mRNA levels of these genes could be nutrigenomic biomarkers for predicting obesity treatment outcome. PMID: 19690434

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  • 相关疾病：
    Gordon Holmes syndrome (GDHS)
  • 亚细胞定位：
    Cytoplasm.
  • 组织特异性：
    Ubiquitous, with the highest levels of expression in testis and peripheral blood leukocytes.
  • 数据库链接：

    HGNC: 21698

    OMIM: 212840

    KEGG: hsa:54476

    UniGene: Hs.487458

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