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  4. Recombinant Human E3 ubiquitin-protein ligase HERC2 (HERC2), partial

Recombinant Human E3 ubiquitin-protein ligase HERC2 (HERC2), partial

  • 中文名称：
    人HERC2重组蛋白
  • 货号：
    CSB-YP010293HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人HERC2重组蛋白
  • 货号：
    CSB-EP010293HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人HERC2重组蛋白
  • 货号：
    CSB-EP010293HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人HERC2重组蛋白
  • 货号：
    CSB-BP010293HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人HERC2重组蛋白
  • 货号：
    CSB-MP010293HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HERC2
  • Uniprot No.：
    O95714
  • 别名：
    D15F37S1; E3 ubiquitin-protein ligase HERC2; HECT and RLD domain containing E3 ubiquitin protein ligase 2; HECT domain and RCC1 like domain containing protein 2; HECT domain and RCC1-like domain-containing protein 2; Hect domain and RLD 2; HERC2; HERC2_HUMAN; jdf2 ; MRT38; p528 ; Probable E3 ubiquitin-protein ligase HERC2; SHEP1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway.
  • 基因功能参考文献：
    1. The results of this study are the first to show an association between HERC2 variants and time to first cSCC post-transplant. PMID: 28456133
    2. By downregulating acetylated LKB1 protein via HERC2, SIRT1 fine-tunes the crosstalk between endothelial and vascular smooth muscle cells to prevent adverse arterial remodeling and maintain vascular homeostasis PMID: 27259994
    3. Evaluated the association of seven OCA2-HERC2 SNPs and haplotypes with pigmentation characteristics (eye, skin, hair and freckles) in the highly admixed and phenotypically heterogeneous Brazilian population. Such SNPs and haplotypes could be deemed as good predictors for the presence of freckles and for skin, eye and hair pigmentation in the Brazilian population. PMID: 28081795
    4. SNP rs12913832 in HERC2 was found to be strongly associated with blue eye colour. SNP associations with hair and skin colour were weaker and genotypes less predictive. PMID: 26286644
    5. Data show that histone H2A deubiquitinase USP16 interacts with E3 ubiquitin-protein ligase HERC2, negatively regulates DNA damage-induced ubiquitin foci formation, and is required for termination of the ubiquitin signal. PMID: 25305019
    6. Results identify HERC2 as a regulator of p53 signaling. PMID: 24722987
    7. results thus suggest that HERC2 regulates the basal turnover of FBXL5, and that this ubiquitin-dependent degradation pathway contributes to the control of mammalian iron metabolism PMID: 24778179
    8. identified HERC2, a HECT domain-containing E3 ligase, as being responsible for polyubiquitination of USP33. PMID: 24855649
    9. given a particular HERC2/OCA2 genotype, males are more prone to have lighter eye colors than predicted by their genotypes, while females tend to have darker eye colors than predicted PMID: 23601698
    10. Studied an autosomal-recessive neurodevelopmental disorder with some phenotypic similarities to Angelman syndrome, found among the Old Order Amish. Our molecular investigation identified a mutation in HERC2 associated with the disease phenotype. PMID: 23243086
    11. Pathogenic changes in HERC2 are associated with nonsyndromic intellectual disability, autism, and gait disturbance. PMID: 23065719
    12. the NEURL4-HERC2 complex participates in the ubiquitin-dependent regulation of centrosome architecture PMID: 22261722
    13. HERC2 rs12913832 region functions as an enhancer regulating OCA2 transcription. PMID: 22234890
    14. In response to double-strand breaks, both HERC2 and RNF168 were specifically modified with SUMO1 at double-strand break sites in a manner dependent on the SUMO E3 ligase PIAS4. PMID: 22508508
    15. These results suggest that HERC2 regulates DNA replication progression and origin firing by facilitating MCM2 phosphorylation. PMID: 21775519
    16. ). Sequence variations in rs11636232 and rs7170852 in HERC2, rs1800407 in OCA2 and rs16891982 in MATP showed additional association with eye colours PMID: 20457063
    17. role in pigmentation characteristics in Spanish population PMID: 20629734
    18. Findings identify a function for HERC2 in regulating BRCA1 stability in opposition to BARD1. The HERC2 expression in breast epithelial cells and breast carcinomas suggests that this mechanism may play a role in breast carcinogenesis. PMID: 20631078
    19. Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory element located within the HERC2 gene inhibiting OCA2 expression PMID: 18172690
    20. We suggest that genetic variants regulating expression of the OCA2 gene exist in the HERC2 gene or, alternatively, within the 11.7 kb of sequence between OCA2 and HERC2, and that most iris color variation in Europeans is explained by those two genes. PMID: 18252221
    21. A single SNP in an evolutionary conserved region within intron 86 of the HERC2 gene determines human blue-brown eye color. PMID: 18252222
    22. Single nucleotide polymorphism in HERC2 gene is associated with ulcerative colitis PMID: 18438405
    23. OCA2 and HERC2 have roles in hair color in Australian adolescents PMID: 18528436
    24. Results confirmed the association of HERC2 rs12913832 with eye colour and showed that this SNP is also significantly associated with skin and hair colouration. PMID: 19208107
    25. Two single nucleotide polymorphisms found in intron 86 (rs12913832) and the 3' UTR region (rs1129038) of the HERC2 gene. PMID: 19472299

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  • 相关疾病：
    Mental retardation, autosomal recessive 38 (MRT38)
  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus. Note=Recruited to sites of DNA damage in response to ionizing radiation (IR) via its interaction with RNF8. May loose association with centrosomes during mitosis.
  • 数据库链接：

    HGNC: 4868

    OMIM: 227220

    KEGG: hsa:8924

    STRING: 9606.ENSP00000261609

    UniGene: Hs.434890

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