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  4. Recombinant Human Disrupted in schizophrenia 1 protein (DISC1), partial

Recombinant Human Disrupted in schizophrenia 1 protein (DISC1), partial

  • 中文名称：
    人DISC1重组蛋白
  • 货号：
    CSB-YP889093HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人DISC1重组蛋白
  • 货号：
    CSB-EP889093HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人DISC1重组蛋白
  • 货号：
    CSB-EP889093HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人DISC1重组蛋白
  • 货号：
    CSB-BP889093HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人DISC1重组蛋白
  • 货号：
    CSB-MP889093HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    DISC1
  • Uniprot No.：
    Q9NRI5
  • 别名：
    C1orf136; DISC1; DISC1_HUMAN; Disrupted in schizophrenia 1; Disrupted in schizophrenia 1 protein; KIAA0457; RP4-730B13.1; SCZD9
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

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DISC1 antibodies

靶点详情

  • 功能：
    Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA-binding. Plays a role, together with PCNT, in the microtubule network formation.
  • 基因功能参考文献：
    1. Significant effect of truncated hDISC1 on glial identity cells along the rostrocaudal axis and their oligodendrocytes specification; appearance of hindbrain oligodendrocyte lineage cells and their premature differentiation may affect cerebrocortical organization and contribute to the pathophysiology of SZ. PMID: 28981898
    2. Study shows that DISC1-mutant cerebral organoids display disorganized structural morphology and impaired proliferation, which is phenocopied by WNT agonism and rescued by WNT antagonism. PMID: 29643329
    3. Results suggest that DISC1 may be involved in the regulation of lactate production in astrocytes to support neuronal activity and associated behaviors. PMID: 29643356
    4. This study showed several gene expression profiles, including DISC1, are associated with age-related changes in White Matter disconnectivity. PMID: 28946750
    5. DISC1 overexpression and misassembly is associated with deficits in long-term memory and attention-related behavior in a tgDISC1 rat model. PMID: 29107702
    6. Findings showed that NOS1AP (rs348624, rs12742393 and rs1415263), DISC1 (rs821633 and rs1000731), DAOA (rs2391191) and GSK3B (rs6438552) SNPs had no association with development of early-onset schizophrenia; however, our finding suggested statistically significant role of the interaction of NOS1AP, DISC1, DAOA and GSK3B polymorphisms in schizophrenia susceptibility. PMID: 29100974
    7. Meta-analysis found that DISC1 polymorphisms increased a risk of schizophrenia, especially in the Chinese population. PMID: 29031911
    8. DISC1 a key molecular lead in psychiatry and neurodevelopment. PMID: 27595595
    9. The nervous system developmental pathway is a potential pathogenesis of sporadic amyotrophic lateral sclerosis, among them, the polymorphism of rs3737597 in DISC1 might play some roles. PMID: 27052956
    10. meta-analysis analyzed the association between DISC1 SNPs rs3738401 and rs821616 with schizophrenia. We found that rs3738401 did not show association with schizophrenia in the Caucasian, Asian or Japanese subgroups PMID: 29410289
    11. DISC1 affects glioblastoma cell development via mitochondria dynamics partly by down regulation of Drp1. PMID: 27852062
    12. In combination with molecular modeling, data support predictions regarding the three-dimensional fold of a DISC1 segment as well as its steric arrangement in complex with a llama heavy chain antibody. PMID: 29324815
    13. Authors found that three pathways that include the homologs of Drosophila Dys, Trio, and Shot were downregulated by introducing a C-terminal truncated mutant DISC1. PMID: 28472294
    14. disrupting DISC1/Ndel1 complex formation prolongs mitotic length and interferes with cell-cycle progression in human cells, and it causes cell-cycle deficits of radial glial cells in the embryonic mouse cortex and human forebrain organoids PMID: 29103808
    15. Study reports sex-specific influence of common disrupted-in-schizophrenia-1 variants on volumes of the basal ganglia, the amygdala and on the cortical surface area. PMID: 27369464
    16. Study found a significant association between the DISC1 gene polymorphism rs6675281 alone, and the combination of rs6675281 and rs821616, and differences in long-term cortical thickness growth in patients with a first-episode of psychosis; and observed an overall difference in cortical thickness, as well as heightened disparities in the frontal and temporal brain regions. PMID: 26209938
    17. HTT forms a ternary protein complex with the scaffolding protein DISC1 and cAMP-degrading phosphodiesterase 4 (PDE4) to regulate PDE4 activity. PMID: 28263187
    18. This theme highlights the importance of understanding precisely how DISC1 can regulate intracellular trafficking, and suggests that a novel approach to the treatment of psychiatric disorders could be provided by targeting this protein and the trafficking machinery with which it interacts. PMID: 27121900
    19. Findings indicate that disrupted-in-schizophrenia 1 (DISC1) and close homolog of L1 may engage in physical and functional interaction in neural development, supporting the notion that DISC1 regulates neurite outgrowth with a receptor belonging to the neural cell adhesion molecules. PMID: 27346367
    20. DISC1 increased the risk for late-onset Alzheimer's disease in northern Han Chinese population. PMID: 27023224
    21. Findings suggest that synapse-associated protein of 97-kDa molecular weight and disrupted in schizophrenia 1 contribute to maintaining Wnt/beta-catenin signaling activity within a homeostatic range by regulating glycogen synthase kinase 3 beta phosphorylation. PMID: 27026592
    22. DISC1 has distinctly folded regions, which are bisected by mental illness-related mutations PMID: 28249940
    23. These results should contribute to reveal DISC1 physiological function and potential pathogenic role in severe mental illnesses PMID: 27466199
    24. This population-based case-control study was carried out to determine whether polymorphisms in DISC1 and NRG1 genes could be associated with schizophrenia in the Chinese population. PMID: 27236031
    25. This study demonstrated that the Increased density of DISC1-immunoreactive oligodendroglial cells in fronto-parietal white matter of patients with paranoid schizophrenia. PMID: 26315603
    26. The present findings, at least in part, provide some clues for further investigating the association of DISC1 variants with SCZ susceptibility PMID: 26945459
    27. DISC1 may be involved in sleep regulation PMID: 27354230
    28. Polymorphisms in DISC1 play a role in vulnerability to opioid dependence in a Polish sample. PMID: 26997180
    29. Hypoxic preconditioning decreases NF-kappaB activity via DISC1. PMID: 26615762
    30. It is anterogradely transported to the neurite tips, together with Lis1, and functions in neurite extension via suppression of GSK3beta activity. PMID: 27333658
    31. DISC1 disruption affects expression of neural cell fate markers and Wnt signaling. PMID: 26299970
    32. These results uncover an unexpected role for DISC1 in normal beta-cell physiology and suggest that DISC1 dysregulation contributes to T2D independently of its importance for cognition. PMID: 26546129
    33. DISC1 gene variations may affect the course of cognitive deficits found in patients suffering from the first episode of non-affective psychosis PMID: 26443054
    34. DISC1 acts as an important regulator of mitochondrial dynamics in both axons and dendrites. PMID: 26553875
    35. An association was found with DISC1 genetic variants and susceptibility to schizophrenia in a Han Chinese population. PMID: 26162659
    36. Results with immature neurons from patients with schizophrenia and bipolar disorder showed common alterations in DISC1 levels and its cellular distribution, cAMP homeostasis, and cell migration PMID: 25620115
    37. results demonstrate that DISC1 protein levels in human lymphocytes are correlated with the diagnosis of schizophrenia independent of smoking and thus present a potential biomarker PMID: 25218871
    38. The results of this student findings provide consistent evidence that the DISC1 Ser704Cys polymorphism influences the thalamic-prefrontal circuits in humans. PMID: 24146131
    39. Transient neonatal disruption of signaling via the C-terminal domain of "disrupted in schizophrenia 1" (DISC1)-a molecule implicated in psychiatric disorders-resulted in a lack of long-term potentiation (LTP) (persistent strengthening of synapses) and experience-dependent potentiation in adulthood. PMID: 26206934
    40. We demonstrated that Ser704Cys-genotype of DISC1 influences (para)hippocampal structure and functioning the dorsal PFC during executive planning, most prominently in unaffected controls PMID: 25533973
    41. Our results revealed association between rare haplotypes and affective disorder providing further support to the hypothesis that DISC1 sequence variations may be related to AD susceptibility PMID: 24090488
    42. These results suggested a possible role of the DISC1 genotype in the early neurodevelopment of human brains, but failed to show its specific role in the neurodevelopmental pathology of schizophrenia. PMID: 25092219
    43. In Disc1-knockout mice, recombinant human DISC1 regulates the dendritic transport of Itpr1 mRNA by directly interacting with its mRNA. PMID: 25821909
    44. In the adult mammalian brain DISC1 plays a critical role in neurite outgrowth and neuronal migration, particularly in the hippocampus. PMID: 25043320
    45. DISC1 knockdown leads to a reduction of VGF in neurons. PMID: 24934694
    46. These findings highlight the importance of the coordinated expression of DISC1-interactome genes for normal cognitive function. PMID: 24940743
    47. This study provided that DISC1 genetic variants reveals a relationship with the structure and functional connectivity of the precuneus in schizophrenia. PMID: 24909300
    48. Expression of the DB7 fusion gene may reduce protein translation to impair brain functions and thereby contribute to the pathogenesis of major psychiatric disorders. PMID: 24908665
    49. DISC1 forms a complex with dysbindin and increases its stability in association with a reduction in ubiquitylation. PMID: 25635053
    50. The results reinforce the role of DISC1 in the association of schizophrenia PMID: 23855403

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  • 相关疾病：
    Schizophrenia 9 (SCZD9)
  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Mitochondrion. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, synapse, postsynaptic density.
  • 组织特异性：
    Ubiquitous. Highly expressed in the dentate gyrus of the hippocampus. Also expressed in the temporal and parahippocampal cortices and cells of the white matter.
  • 数据库链接：

    HGNC: 2888

    OMIM: 604906

    KEGG: hsa:27185

    STRING: 9606.ENSP00000355593

    UniGene: Hs.13318

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