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  4. Recombinant Human Deubiquitinating protein VCIP135 (VCPIP1), partial

Recombinant Human Deubiquitinating protein VCIP135 (VCPIP1), partial

  • 中文名称：
    人VCPIP1重组蛋白
  • 货号：
    CSB-YP839350HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人VCPIP1重组蛋白
  • 货号：
    CSB-EP839350HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人VCPIP1重组蛋白
  • 货号：
    CSB-EP839350HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人VCPIP1重组蛋白
  • 货号：
    CSB-BP839350HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人VCPIP1重组蛋白
  • 货号：
    CSB-MP839350HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    VCPIP1
  • Uniprot No.：
    Q96JH7
  • 别名：
    Deubiquitinating protein VCIP135; DUBA3; KIAA1850; Valosin containing protein (p97)/p47 complex interacting protein 1; Valosin containing protein p97/p47 complex interacting protein 1; Valosin containing protein p97/p47 complex interacting protein p135; Valosin-containing protein p97/p47 complex-interacting protein 1; Valosin-containing protein p97/p47 complex-interacting protein p135; VCIP1_HUMAN; VCIP135; VCP/p47 complex-interacting 135-kDa protein; Vcpip1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

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VCPIP1 antibodies

靶点详情

  • 功能：
    Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP. Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains.; (Microbial infection) Regulates the duration of C.botulinum neurotoxin type A (BoNT/A) intoxication by catalyzing deubiquitination of Botulinum neurotoxin A light chain (LC), thereby preventing LC degradation by the proteasome, and accelerating botulinum neurotoxin intoxication in patients.
  • 基因功能参考文献：
    1. BoNT/A catalytic light chain binds to, and is a substrate for, the ubiquitin ligase HECTD2. However, the light chain evades proteasomal degradation by the dominant effect of a deubiquitinating enzyme, VCIP135/VCPIP1. This deubiquitinating enzyme binds BoNT/A light chain directly. PMID: 28584101
    2. Phosphorylation and ubiquitination are coordinated via VCIP135 to control Golgi membrane dynamics in the cell cycle. PMID: 25904330
    3. VCIP135 phosphorylation regulates its Golgi membrane association and p97 interaction, and thus contributes to the tight control of the Golgi disassembly and reassembly process during the cell cycle. PMID: 24163436
    4. the phosphorylation of VCIP135 on Threonine-760 and Serine-767 inhibits p97-mediated Golgi membrane fusion at mitosis PMID: 23500464
    5. evidence of tyrosine phosphorylation during sperm capacitation PMID: 12509440

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Endoplasmic reticulum. Golgi apparatus, Golgi stack.
  • 数据库链接：

    HGNC: 30897

    OMIM: 611745

    KEGG: hsa:80124

    STRING: 9606.ENSP00000309031

    UniGene: Hs.632066

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