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  4. Recombinant Human Dedicator of cytokinesis protein 4 (DOCK4), partial

Recombinant Human Dedicator of cytokinesis protein 4 (DOCK4), partial

  • 中文名称：
    人DOCK4重组蛋白
  • 货号：
    CSB-YP854021HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人DOCK4重组蛋白
  • 货号：
    CSB-EP854021HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人DOCK4重组蛋白
  • 货号：
    CSB-EP854021HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人DOCK4重组蛋白
  • 货号：
    CSB-BP854021HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人DOCK4重组蛋白
  • 货号：
    CSB-MP854021HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    DOCK4
  • Uniprot No.：
    Q8N1I0
  • 别名：
    Dedicator of cytokinesis protein 4; Dock4; DOCK4_HUMAN; KIAA0716
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form. Involved in regulation of adherens junction between cells. Plays a role in cell migration.; Has a higher guanine nucleotide exchange factor activity compared to other isoforms.
  • 基因功能参考文献：
    1. DOCK4 over expression suppresses selfrenewal and tumorigenicity of glioblastoma (GBM) stem-like cells. Accordingly in the frame of GBM median of survival, increased level of DOCK4 predicts improved patient survival. PMID: 28925399
    2. DOCK4 signalling is necessary for lateral filopodial protrusions and tubule remodelling prior to vascular lumen formation PMID: 26129894
    3. These data identify DOCK4 as a putative 7q gene whose reduced expression can lead to erythroid dysplasia PMID: 26578796
    4. activator DOCK4 as a key component of the TGF-beta/Smad pathway that promotes lung ADC cell extravasation and metastasis. PMID: 25644601
    5. The study found significant associations between autism and a SNP of the DOCK4 gene. PMID: 24599690
    6. The Atypical guanine nucleotide exchange factor Dock4 regulates neurite differentiation through modulation of Rac1 GTPase and actin dynamics. PMID: 23720743
    7. This study revealed ROCK4 as novel schizophrenia candidate genes in the Jewish population. PMID: 21682944
    8. novel epigenetic alterations in myelodysplastic leukocytes and implicate DOCK4 as a pathogenic gene located on the 7q chromosomal region. PMID: 21532034
    9. Evidence for the involvement of DOCK4 in autism susceptibility was supported by independent replication of association at rs2217262 and the finding of a deletion segregating in a sib-pair family PMID: 19401682
    10. Data suggest that exonic deletions of DOCK4 may act as a risk factor for reading impairment. Genomic disruption of both DOCK4 and CNTNAP5 genes may have an additive effect and may result in a more severe autism spectrum phenotype. PMID: 20346443
    11. Taken together, these results suggest that Dock4 plays an important role in the regulation of cell migration through activation of Rac1, and that RhoG is a key upstream regulator for Dock4. PMID: 17027967
    12. DOCK4 may be regulated by PIP(3) to exert its function PMID: 18459162
    13. DOCK4 interacts with the beta-catenin degradation complex, consisting of the proteins adenomatosis polyposis coli, Axin and glycogen synthase kinase 3beta. PMID: 18641688
    14. Cell migration is regulated by platelet-derived growth factor receptor endocytosis, which involves DOCK4. PMID: 19528233

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  • 亚细胞定位：
    Cell membrane. Cell projection. Cytoplasm, cytosol.
  • 蛋白家族：
    DOCK family
  • 组织特异性：
    Widely expressed at low level. Highly expressed in skeletal muscle, prostate and ovary.; [Isoform 2]: May be specifically expressed in the brain and eye.
  • 数据库链接：

    HGNC: 19192

    OMIM: 607679

    KEGG: hsa:9732

    STRING: 9606.ENSP00000404179

    UniGene: Hs.654652

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