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  4. Recombinant Human DIS3-like exonuclease 2 (DIS3L2), partial

Recombinant Human DIS3-like exonuclease 2 (DIS3L2), partial

  • 中文名称：
    人DIS3L2重组蛋白
  • 货号：
    CSB-YP818258HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人DIS3L2重组蛋白
  • 货号：
    CSB-EP818258HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人DIS3L2重组蛋白
  • 货号：
    CSB-EP818258HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人DIS3L2重组蛋白
  • 货号：
    CSB-BP818258HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人DIS3L2重组蛋白
  • 货号：
    CSB-MP818258HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    DIS3L2
  • Uniprot No.：
    Q8IYB7
  • 别名：
    DI3L2_HUMAN; DIS3 L2; DIS3 mitotic control homolog (S. cerevisiae) like 2; DIS3 mitotic control homolog like 2; DIS3-like exonuclease 2; Dis3l2; FLJ36974; MGC42174
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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DIS3L2 antibodies

靶点详情

  • 功能：
    3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.
  • 基因功能参考文献：
    1. The evidence has been presented that Dis3l2 controls miRNA-9 production. PMID: 27881476
    2. Our findings establish the role of DIS3L2 and oligouridylation as the cytoplasmic quality control for highly structured ncRNAs PMID: 27647875
    3. Studies indicate important roles of the exoribonucleases DIS3L2 and XRN1 in cellular function, viability and disease. PMID: 27911720
    4. these results indicate that catalytically inactive DIS3L2, characteristic of Perlman syndrome, can lead to deregulation of its target RNAs to disturb transcriptome homeostasis. PMID: 27431325
    5. DIS3L2 interacts with Ago2 and governs target RNA-directed miRNA degradation. PMID: 26809675
    6. DIS3L2 is the missing component of the LIN28-TUT4/7-DIS3L2 pathway required for the repression of let-7 in pluripotent cells. PMID: 24141620
    7. in cellular models DIS3L2 knockdown is associated with abnormalities of cell growth and division PMID: 23613427
    8. Germline mutations in DIS3L2 cause the Perlman syndrome of overgrowth and Wilms tumor susceptibility. PMID: 22306653

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  • 相关疾病：
    Perlman syndrome (PRLMNS)
  • 亚细胞定位：
    Cytoplasm. Cytoplasm, P-body.
  • 蛋白家族：
    RNR ribonuclease family, DIS3L2 subfamily
  • 数据库链接：

    HGNC: 28648

    OMIM: 267000

    KEGG: hsa:129563

    STRING: 9606.ENSP00000315569

    UniGene: Hs.732236

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