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  4. Recombinant Human Cysteine-rich motor neuron 1 protein (CRIM1), partial

Recombinant Human Cysteine-rich motor neuron 1 protein (CRIM1), partial

  • 中文名称：
    Recombinant Human Cysteine-rich motor neuron 1 protein(CRIM1) ,partial
  • 货号：
    CSB-YP889163HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Cysteine-rich motor neuron 1 protein(CRIM1) ,partial
  • 货号：
    CSB-EP889163HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Cysteine-rich motor neuron 1 protein(CRIM1) ,partial
  • 货号：
    CSB-EP889163HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Cysteine-rich motor neuron 1 protein(CRIM1) ,partial
  • 货号：
    CSB-BP889163HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Cysteine-rich motor neuron 1 protein(CRIM1) ,partial
  • 货号：
    CSB-MP889163HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CRIM1
  • Uniprot No.：
    Q9NZV1
  • 别名：
    AU015004; CRIM 1; CRIM-1; CRIM1; CRIM1_HUMAN; Cysteine rich motor neuron 1 protein; Cysteine rich repeat containing protein S52; Cysteine rich transmembrane BMP regulator 1 (chordin like); Cysteine rich transmembrane BMP regulator 1; Cysteine-rich motor neuron protein 1; Cysteine-rich repeat-containing protein S52; MGC138194; Processed cysteine rich motor neuron 1 protein; Processed cysteine-rich motor neuron 1 protein; S52
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

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CRIM1 antibodies

靶点详情

  • 功能：
    May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface.
  • 基因功能参考文献：
    1. CRIM1 regulates the expression of several epithelial-mesenchymal transition (EMT) related factors and appears to play a role in suppressing migration and invasion through control of EMT. PMID: 29607933
    2. these findings implicate CRIM1 in endothelial cell development and homeostasis in the coronary vasculature. PMID: 27803996
    3. These observations provide evidence for the first time that CRIM1 plays a role in cancer cells by enhancing the migration and adhesion and increasing the expression of N-CAD and E-CAD. PMID: 26653968
    4. CRIM1 is the causative gene for Colobomatous macrophthalmia with microcornea syndrome and is important for eye development. PMID: 25561690
    5. Knock down of CRIM1 had no effect on VEGF-induced proliferation or migration of umbilical vein endothelial cells (HUVECs), indicating that basal CRIM1 is not involved in the proliferation or migration of endothelial cells. PMID: 25956066
    6. Data suggest that CRIM1 plays role in cancer progression/metastasis, epithelial-mesenchymal transition, and neoplastic angiogenesis. [REVIEW] PMID: 25088037
    7. BMPs inhibitor CRIM1 is increased and correlates with higher levels of serum PIPIII showing an imbalance in favor of pro-fibrotic mechanisms in CHF. PMID: 24617547
    8. CRIM1 is an early response gene in the presence of both angiogenic stimulation (VEGF) and environmental (extracellular matrix) factors, and Erk and FAK might be involved in the upregulation of CRIM1 mRNA expression in vascular endothelial cells. PMID: 25086356
    9. Study demonstrated that CRIM1 is expressed at high levels in resistant leukemia cells, indicating that CRIM1 may play a role in drug-resistance. PMID: 21036735
    10. CRIM1 has a role in capillary formation and maintenance during angiogenesis PMID: 12464430
    11. CRIM1 modulates BMP activity by affecting its processing and delivery to the cell surface PMID: 12805376

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  • 亚细胞定位：
    [Processed cysteine-rich motor neuron 1 protein]: Secreted.; Cell membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Expressed in pancreas, kidney, skeletal muscle, lung, placenta, brain, heart, spleen, liver and small intestine. Expressed in blood vessels (at protein level).
  • 数据库链接：

    HGNC: 2359

    OMIM: 606189

    KEGG: hsa:51232

    STRING: 9606.ENSP00000280527

    UniGene: Hs.699247

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