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  4. Recombinant Human Cleavage and polyadenylation specificity factor subunit 1 (CPSF1), partial

Recombinant Human Cleavage and polyadenylation specificity factor subunit 1 (CPSF1), partial

  • 中文名称：
    Recombinant Human Cleavage and polyadenylation specificity factor subunit 1(CPSF1) ,partial
  • 货号：
    CSB-YP604617HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Cleavage and polyadenylation specificity factor subunit 1(CPSF1) ,partial
  • 货号：
    CSB-EP604617HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Cleavage and polyadenylation specificity factor subunit 1(CPSF1) ,partial
  • 货号：
    CSB-EP604617HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Cleavage and polyadenylation specificity factor subunit 1(CPSF1) ,partial
  • 货号：
    CSB-BP604617HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Cleavage and polyadenylation specificity factor subunit 1(CPSF1) ,partial
  • 货号：
    CSB-MP604617HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CPSF1
  • Uniprot No.：
    Q10570
  • 别名：
    CPSF1; CPSF160Cleavage and polyadenylation specificity factor subunit 1; Cleavage and polyadenylation specificity factor 160 kDa subunit; CPSF 160 kDa subunit
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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CPSF1 antibodies

靶点详情

  • 功能：
    Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction. May play a role in eye morphogenesis and the development of retinal ganglion cell projections to the midbrain.
  • 基因功能参考文献：
    1. Knockdown of CPSF inhibits the proliferation, migration and invasion of ovarian carcinoma cells. PMID: 29358555
    2. CPSF1 was identified among protein-binding candidates. A consensus polyadenylation signal AAUAAA is present in intron 6 of IL7 receptor directly downstream from the 5' splice site. Mutations to this site and CPSF1 knockdown increased exon 6 inclusion. PMID: 23151878
  • 亚细胞定位：
    Nucleus, nucleoplasm.
  • 蛋白家族：
    CPSF1 family
  • 组织特异性：
    Widely expressed, with high expression in the retina.
  • 数据库链接：

    HGNC: 2324

    OMIM: 606027

    KEGG: hsa:29894

    STRING: 9606.ENSP00000339353

    UniGene: Hs.493202

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