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  4. Recombinant Human Cip1-interacting zinc finger protein (CIZ1), partial

Recombinant Human Cip1-interacting zinc finger protein (CIZ1), partial

  • 中文名称：
    Recombinant Human Cip1-interacting zinc finger protein(CIZ1) ,partial
  • 货号：
    CSB-YP891781HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Cip1-interacting zinc finger protein(CIZ1) ,partial
  • 货号：
    CSB-EP891781HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Cip1-interacting zinc finger protein(CIZ1) ,partial
  • 货号：
    CSB-EP891781HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Cip1-interacting zinc finger protein(CIZ1) ,partial
  • 货号：
    CSB-BP891781HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Cip1-interacting zinc finger protein(CIZ1) ,partial
  • 货号：
    CSB-MP891781HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CIZ1
  • Uniprot No.：
    Q9ULV3
  • 别名：
    CDKI; CDKN1A-interacting zinc finger protein 1; Cip1-interacting zinc finger protein; CIZ1; CIZ1_HUMAN; cyclin dependent inhibitor 1A; LSFR1; Melanoma differentiation-associated protein; NP94; Nuclear protein NP94; OPHN3; P21; Zinc finger protein 356; ZNF356
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

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CIZ1 antibodies

靶点详情

  • 功能：
    May regulate the subcellular localization of CIP/WAF1.
  • 基因功能参考文献：
    1. data reveal that CIZ1 plays a major role in ensuring stable association of Xist RNA within the Xi territory. PMID: 28923964
    2. CIZ1 activates YAP/TAZ signaling in human hepatocellular carcinoma cells. PMID: 26515335
    3. CIZ1 is a kinase sensor that promotes initiation of DNA replication at low kinase levels, when in a hypophosphorylated state that is permissive for cyclin-A-CDK2 interaction and delivery to licensed origins. PMID: 25736292
    4. The results of this study showed CIZ1 will play a less important role in dystonia patient diagnosis than previously thought because variants of unclear significance are observed in approximately 1% of adult-onset sporadic dystonia patients in Germany. PMID: 25778706
    5. Our study demonstrated that CIZ1 played an oncogenic role in the progression of GBC and CIZ1 might be a promising target for the treatment of GBC PMID: 25427641
    6. This study suggested that No mutations in CIZ1 in twelve adult-onset primary cervical dystonia families. PMID: 23813719
    7. CIZ1 may be involved in colon cancer progression by regulating cell proliferation, cell cycle, apoptosis and colony formation. PMID: 24126760
    8. Variant Ciz1 is a strong candidate for a cancer-specific single marker capable of identifying early-stage lung cancer. PMID: 23074256
    9. Mutations in CIZ1 may cause adult onset, primary cervical dystonia PMID: 22447717
    10. alternatively spliced variant of Ciz1 is associated with cancer. PMID: 20831784
    11. data indicate that Ciz1 is localized in the nucleus and is expressed in a wide range of tissues, especially the pancreas and the brain; formulated a consensus DNA sequence, ARYSR(0-2)YYAC, recognized by Ciz1 PMID: 12824700
    12. Findings revealed the inherent role of Ciz1, a novel DNA binding and ER coactivator, in amplifying estrogenic responses and promoting breast cancer tumorigenesis. PMID: 17108141
    13. conditional exclusion of exon 4 influences the spatial distribution of the Ciz1 protein within the nucleus, showing that CIZ1 alternative splicing could influence organized patterns of DNA replication PMID: 17508423
    14. Ciz1 is a nuclear zinc finger protein interacting with p21, and is a DNA replication factor. The region of Ciz1 necessary for the interaction with ERH spans residues 531-644, encompassing its first zinc finger motif PMID: 18081865
    15. An isoform of CIZ1 which lacks a glutamine-rich region, due to alternative splicing in exon 8, is upregulated in Alzheimer's brains relative to the full-length CIZ1 protein. PMID: 18583151

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  • 相关疾病：
    Defects in CIZ1 may be a cause of adult onset primary cervical dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Cervical dystonia or spasmodic torticollis, the most common form of focal dystonia, is characterized by involuntary contractions of the neck muscles, which produce abnormal posturing of the head upon the trunk.
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 16744

    OMIM: 611420

    KEGG: hsa:25792

    STRING: 9606.ENSP00000362029

    UniGene: Hs.212395

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