Recombinant Human Carbohydrate-responsive element-binding protein (MLXIPL), partial

1. ChREBP regulates gene transcription related to glucose and lipid metabolism. Findings from knockout mice and human subjects suggest that ChREBP helps to induce hepatic steatosis, dyslipidemia, and glucose intolerance. [review] PMID: 27919710
2. The results of this population-based study provide evidence for a relationship between lipid regulatory gene polymorphisms including GCKR (rs780094), GCKR (rs1260333), FADS (rs174547), and MLXIPL (rs3812316) with dyslipidemia in an Iranian population. PMID: 29858861
3. Data (including data from studies using tissues/cells from transgenic mice) suggest that ChREBPalpha up-regulates expression and activity of NRF2, initiating mitochondrial biogenesis in beta-cells; induction of NRF2 is required for ChREBPalpha-mediated effects and for glucose-stimulated beta-cell proliferation. [NRF2 = nuclear factor (erythroid-derived 2)-like 2 protein] PMID: 29764859
4. ChREBP was initially studied as a master regulator of lipogenesis in liver and fat tissue, it is now clear that ChREBP functions as a central metabolic coordinator in a variety of cell types in response to environmental and hormonal signals, with wide implications in health and disease. PMID: 28768172
5. A nutrient-sensitive mTOR/ChREBP regulated transcriptional network could be a novel target to improve beta cell survival and glucose homeostasis in diabetes. PMID: 28606928
6. these findings support a carbohydrate-mediated, ChREBP-driven mechanism that contributes to hepatic insulin resistance. PMID: 27669460
7. results indicated that the age and total cholesterol concentrations were independent influential factors of ChREBP methylation and DNMT1 variants could probably influence LDL-C to further modify ChREBP DNA methylation PMID: 27281235
8. p = 6.69 x 10(-9) ] on chr7 at the carbohydrate-responsive element-binding protein-encoding (MLXIPL) gene locus displayed significant protective characteristics, while another variant rs6982502 [0.76 (0.68-0.84); p = 5.31 x 10(-7) ] on chr8 showed similar but weaker properties. PMID: 27599772
9. ChREBP role in non-alcoholic fatty liver disease.The involvement of ChREBP in FASN promoter histone modification. PMID: 28027934
10. This cross-sectional study suggests that MLXIPL rs3812316 genotypes may be associated with Triglyceride levels. there were significantly different genotype distributions in two TG categories: (1) subjects with normal TG values had a significantly higher G allele frequency than those with elevated TG levels PMID: 27854512
11. The results revealed the novel mechanism by which HNF-4alpha promoted ChREBP transcription in response to glucose, and also demonstrated that ChREBP-alpha and HNF-4alpha synergistically increased ChREBP-beta transcription. PMID: 27029511
12. High glucose-mediated induction of PDGF-C via ChREBP in mesangial cells contributes to the development of glomerular mesangial expansion in diabetes. PMID: 27033449
13. Diet-induced obesity increases basal expression of ChREBPbeta, which may increase the risk of developing hepatic steatosis, and fructose-induced activation is independent of gluconeogenesis. PMID: 26526060
14. Data suggest that expression of ChREBPbeta isoform is up-regulated in pancreatic beta-cells in response to elevated levels of glucose (i.e., hyperglycemic conditions). PMID: 26384380
15. Polymorphisms in lipid level modifier MLXIPL, GCKR, GALNT2, CILP2, ANGPTL3 and TRIB1 genes are highly associated with plasma lipid level changes. PMID: 25573592
16. Single-nucleotide polymorphisms alleles near MLXIPL that were associated with higher coffee consumption. PMID: 25288136
17. A major function of Mio in mitosis is to regulate the activation/deactivation of Plk1 and Aurora A. PMID: 26124292
18. the single nucleotide polymorphism of MLXIPL is significantly associated with Non-alcoholic Fatty Liver Disease. PMID: 26177557
19. results demonstrate that AGEs-RAGE signaling enhances cancer cell proliferation in which AGEs-mediated ChREBP induction plays an important role. PMID: 25111846
20. Significant linkage disequilibria were noted among ZNF259, BUD13 and MLXIPL SNPs and serum lipid levels. PMID: 24989072
21. demonstrates that Chrebp interacts with AR and regulates its transcriptional activity PMID: 24845031
22. The MLXIPL-rs3812316 was associated with lower baseline triglycerides and lower hypertriglyceridemia. PMID: 24448738
23. FLII is a component of the ChREBP transcriptional complex and negatively regulates ChREBP function in cancer cells. PMID: 24055811
24. High glucose-induced, ChREBP-mediated, and normoxic HIF-1alpha activation that may be partially responsible for neovascularization in both diabetic and age-related retinopathy. PMID: 24664750
25. The ChREBP mutant, W130A, did not exhibit HG-induced lipid accumulation and fibrotic proteins, suggesting that the Trp-130 residue in the MCR3 domain is important in the development of glomerulosclerosis. PMID: 24616092
26. The ChREBP expression may be reflective of an aerobic metabolic phenotype that may conflict with hypoxia-induced signalling but provide a mechanism for growth at the oxygenated edge of the tumours. PMID: 24366300
27. ChREBP plays a key role in reprogramming glucose and lipid metabolism in human cytomegalovirus infection. PMID: 24449882
28. Data suggest that CHREBP is a central regulator of glycolysis/lipogenesis in liver and apoptosis/proliferation in specific cell types. [REVIEW] PMID: 23597489
29. Data suggest that the activity of CHREBP is regulated via various mechanisms and that CHREBP is involved in the modulation of glucose and lipid metabolism in liver, pancreatic beta-cells, and adipose tissue. [REVIEW] PMID: 23604004
30. Farnesoid X receptor inhibits the transcriptional activity of carbohydrate response element binding protein in human hepatocytes. PMID: 23530060
31. de novo lipogenesis predicts metabolic health in humans in a tissue-specific manner and is likely regulated by glucose-dependent carbohydrate-responsive element-binding protein activation. PMID: 23443556
32. Data from obese adolescents with prediabetes/early type 2 diabetes suggest that expression of ChREBP-alpha/beta in abdominal subcutaneous adipose tissue is inversely related to hyperglycemia severity and positively correlated to insulin resistance. PMID: 23209190
33. ChREBP overexpression induced expression of stearoyl-CoA desaturase 1 (Scd1), the enzyme responsible for the conversion of saturated fatty acids (SFAs) into MUFAs PMID: 22546860
34. The rs3812316 and the haplotypes in ChREBP gene appeared to be related to high susceptibility to CAD PMID: 21726544
35. Multiple linear regression models based on 2373 individuals of Asian origin showed that the H allele of the MLXIPL gene was significantly associated with decreased concentrations of plasma triglycerides. PMID: 21938000
36. ChREBP-beta expression in human adipose tissue predicts insulin sensitivity, indicating that it may be an effective target for treating diabetes. PMID: 22466288
37. Our study reports that PP2A activity is dispensable for ChREBP activation in response to glucose and that dephosphorylation on Ser-196 is not sufficient to promote ChREBP nuclear translocation in the absence of a rise in glucose metabolism. PMID: 21835137
38. an important mechanism by which importin-alpha and 14-3-3 control movement of ChREBP in and out of the nucleus in response to changes in glucose levels in liver PMID: 21665952
39. sorcin retains ChREBP in the cytosol at low glucose concentrations and may act as a Ca(2+) sensor for glucose-induced nuclear translocation and the activation of ChREBP-dependent genes. PMID: 22338092
40. The dramatic increase of ChREBP mRNA and protein levels during preadipocyte differentiation suggests a role in adipogenesis. PMID: 21840420
41. ChREBP may function as a transcriptional repressor as well as an activator. PMID: 21811631
42. in immortalized hepatocytes and in HepG2 hepatoma cells, only SREBP1c was able to induce adiponutrin/PNPLA3 expression, whereas ChREBP was unable to modulate its expression PMID: 21145868
43. ChREBP is a critical and direct mediator of glucose repression of PPARalpha gene expression in pancreatic beta-cells PMID: 21282101
44. These results suggest that the O-linked glycosylation of ChREBP itself or other proteins that regulate ChREBP is essential for the production of functional ChREBP. PMID: 21036147
45. a new nuclear export signal site ("NES1") of ChREBP was reported. PMID: 20025850
46. suppression of ChREBP led to a p53-dependent reduction in tumor growth. These results demonstrate that ChREBP plays a key role both in redirecting glucose metabolism to anabolic pathways and suppressing p53 activity PMID: 19995986
47. we were not able to find any statistically significant association between the single nucleotide polymorphisms in the FAS, ChREBP and SREPB-1 genes and an increased risk of breast cancer PMID: 19252981
48. This evolutionally conserved mechanism may play an essential role in glucose-responsive gene regulation. PMID: 16644671
49. Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides. PMID: 18193046
50. Glucose activates ChREBP by increasing its rate of nuclear entry and relieving repression of its transcriptional activity.( PMID: 18591247

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HGNC: 12744

OMIM: 605678

KEGG: hsa:51085

STRING: 9606.ENSP00000320886

UniGene: Hs.647055