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  4. Recombinant Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (FTSJD2), partial

Recombinant Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (FTSJD2), partial

  • 中文名称：
    Recombinant Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1(FTSJD2) ,partial
  • 货号：
    CSB-YP847611HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1(FTSJD2) ,partial
  • 货号：
    CSB-EP847611HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1(FTSJD2) ,partial
  • 货号：
    CSB-EP847611HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1(FTSJD2) ,partial
  • 货号：
    CSB-BP847611HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1(FTSJD2) ,partial
  • 货号：
    CSB-MP847611HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CMTR1
  • Uniprot No.：
    Q8N1G2
  • 别名：
    Cap methyltransferase 1; Cap-specific mRNA (nucleoside-2''-O-)-methyltransferase 1; Cap1 2''O-ribose methyltransferase 1; CMTR1; CMTR1_HUMAN; FLJ22156; FtsJ methyltransferase domain containing 2; FtsJ methyltransferase domain-containing protein 2; FTSJD 2; hMTr1; Interferon-stimulated gene 95 kDa protein; ISG95; KIAA0082; MTr1; OTTHUMP00000016324; Uncharacterized protein KIAA0082
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.
  • 基因功能参考文献：
    1. Regulation and function of CMTR1-dependent mRNA cap methylation. PMID: 28971629
    2. Crystal structures of the active CMTr1 catalytic domain in complex with a methyl group donor and a capped oligoribonucleotide are examined, thereby revealing the mechanism of specific recognition of capped RNA. PMID: 24402442
    3. hMTr1 catalyzes specific methylation of the 2'-O-ribose of the first nucleotide of a capped RNA transcript. PMID: 20713356
    4. The results presented in this work indicate that ISG95 is part of the interferon response pathway and functions in the pre-mRNA processing events mediated by the C-terminal domain of the RNA polymerase II. PMID: 18533109
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 21077

    OMIM: 616189

    KEGG: hsa:23070

    STRING: 9606.ENSP00000362550

    UniGene: Hs.520102

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