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  4. Recombinant Human CDGSH iron-sulfur domain-containing protein 2 (CISD2), partial

Recombinant Human CDGSH iron-sulfur domain-containing protein 2 (CISD2), partial

  • 中文名称：
    Recombinant Human CDGSH iron-sulfur domain-containing protein 2(CISD2),partial
  • 货号：
    CSB-YP839803HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human CDGSH iron-sulfur domain-containing protein 2(CISD2),partial
  • 货号：
    CSB-EP839803HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human CDGSH iron-sulfur domain-containing protein 2(CISD2),partial
  • 货号：
    CSB-EP839803HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human CDGSH iron-sulfur domain-containing protein 2(CISD2),partial
  • 货号：
    CSB-BP839803HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human CDGSH iron-sulfur domain-containing protein 2(CISD2),partial
  • 货号：
    CSB-MP839803HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CISD2
  • Uniprot No.：
    Q8N5K1
  • 别名：
    1500009M05Rik; 1500026J14Rik; 1500031D15Rik; AI848398; B630006A20Rik; CDGSH iron sulfur domain 2; CDGSH iron-sulfur domain-containing protein 2; CDGSH type domain 2; CISD2; CISD2_HUMAN; Endoplasmic reticulum intermembrane small protein; ERIS; Miner1; MitoNEET related 1; MitoNEET-related 1 protein; NAF-1; Noxp70; Nutrient deprivation autophagy factor 1; Nutrient-deprivation autophagy factor-1; OTTHUMP00000219576; RGD1566242; WFS2; Zcd2; Zinc finger; Zinc finger; CDGSH type domain 2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

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CISD2 antibodies

靶点详情

  • 功能：
    Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy.
  • 基因功能参考文献：
    1. CDGSH iron-sulfur domain-containing protein 2 (CISD2) Wolfram syndrome type 2 (WFS2) primary fibroblast cell lines showed consistent reduction in proliferation. PMID: 29239282
    2. CISD2 haploinsufficiency disrupts calcium homeostasis, causing ER stress and subsequent nonalcoholic fatty liver disease and nonalcoholic steatohepatitis PMID: 29166610
    3. CISD2 was increased in glioma samples and was associated with poor prognosis and aggressive tumor behavior. The miR449a/CISD2/beclin1mediated autophagy regulatory network contributed to the proliferation of glioma cells PMID: 28983596
    4. CISD2 is down-regulated in gastric cancer, and its effects on the inhibition of cellular proliferation, metastatic ability, and increased chemotherapy sensitivity are mediated by antagonism to 5-FU-induced autophagy through the AKT/mTOR pathway. PMID: 28857517
    5. The c.103 + 1G > A mutation resulted in the loss of functional CISD2 protein in the two Italian Wolfram syndrome type 2 patients. PMID: 29237418
    6. CISD2 was up-regulated in laryngeal squamous cell carcinoma PMID: 27007153
    7. CISD2 could be an independent prognostic factor for PC and suggested that the CISD2/Wnt/beta-catenin pathway contributed to the proliferation of PC and EMT PMID: 27983920
    8. the patient that we describe in this report with the c.215A > G missense CISD2 variant had the classical features of Wolfram syndrome type 1. The c.215A > G (p.Asn72Ser) variant does not induce CISD2 RNA mis-splicing or a reduction in CISD2 protein levels. Thus, we report a novel missense homozygous CISD2 mutation in a patient with clinical features that differ from previously reported Wolfram syndrome 2 case reports. PMID: 28335035
    9. CISD2 exerts anti-apoptotic and anti-inflammatory effects in neural cells; and (2) curcumin can attenuate the downregulation of CISD2 in SCI and LPS-treated astrocytes. PMID: 26387034
    10. CISD2 protein may serve as a candidate prognostic marker and a novel therapeutic target for hepatocellular carcinoma (HCC) and play an important role in promoting proliferation and enhanced progression of HCC. PMID: 26722601
    11. The findings suggested that CISD2 haplotype-tagging single nucleotide polymorphisms are not associated with Alzheimer's disease risk. PMID: 26154755
    12. NAF-1 is a BCL-2-associated co-factor that targets BCL-2 for antagonism of the autophagy pathway at the endoplasmic reticulum. PMID: 20010695
    13. NAF-1 as a previously unidentified cell target of anti-diabetes thiazolidinedione drugs. PMID: 23717386
    14. provides the first structural information, to our knowledge, for future targeting of the NAF-1-Bcl-2 complex in the regulation of apoptosis/autophagy in cancer biology PMID: 24706857
    15. High CISD2 expression was significantly associated with gastric cancer. PMID: 26565812
    16. NAF-1 is a major player in the metabolic regulation of breast cancer cells. PMID: 26621032
    17. A novel CISD2 mutation is associated with wolfram syndrome 2. PMID: 25371195
    18. Studied the expression pattern and clinicopathological significance of CISD2 in patients with early-stage cervical cancer. PMID: 25134919
    19. Data show that the protein levels of NAF-1 (CISD2) and mNT (CISD1) are elevated in human epithelial breast cancer cells. PMID: 23959881
    20. CISD2 has a role in lifespan control and disease [review] PMID: 20649540
    21. Novel mutation, new phenotypic variant with no diabetes insipidus, presence of peptic ulcer disease, platelet aggregation defect PMID: 14724730
    22. A single missense mutation was identified in a novel, highly conserved zinc-finger gene, ZCD2, in three consanguineous families of Jordanian descent with Wolfram syndrome (WFS). PMID: 17846994
    23. The authors show that Miner1 is a homodimer harboring two redox-active 2Fe-2S clusters, indicating for the first time an association of a redox-active FeS protein with Wolfram Syndrome 2. PMID: 19580816

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  • 相关疾病：
    Wolfram syndrome 2 (WFS2)
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein. Note=According to PubMed:20010695, it mainly localizes to the endoplasmic reticulum. However, experiments in mouse showed that it mainly localizes to the mitochondrion outer membrane.
  • 蛋白家族：
    CISD protein family, CISD2 subfamily
  • 组织特异性：
    Testis, small intestine, kidney, lung, brain, heart, pancreas and platelets.
  • 数据库链接：

    HGNC: 24212

    OMIM: 604928

    KEGG: hsa:493856

    STRING: 9606.ENSP00000273986

    UniGene: Hs.444955

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