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  4. Recombinant Human Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (ARFGEF1), partial

Recombinant Human Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (ARFGEF1), partial

  • 中文名称：
    Recombinant Human Brefeldin A-inhibited guanine nucleotide-exchange protein 1(ARFGEF1) ,partial
  • 货号：
    CSB-YP896754HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Brefeldin A-inhibited guanine nucleotide-exchange protein 1(ARFGEF1) ,partial
  • 货号：
    CSB-EP896754HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Brefeldin A-inhibited guanine nucleotide-exchange protein 1(ARFGEF1) ,partial
  • 货号：
    CSB-EP896754HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Brefeldin A-inhibited guanine nucleotide-exchange protein 1(ARFGEF1) ,partial
  • 货号：
    CSB-BP896754HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Brefeldin A-inhibited guanine nucleotide-exchange protein 1(ARFGEF1) ,partial
  • 货号：
    CSB-MP896754HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ARFGEF1
  • Uniprot No.：
    Q9Y6D6
  • 别名：
    ARFGEF1; ARFGEP1; BIG1Brefeldin A-inhibited guanine nucleotide-exchange protein 1; Brefeldin A-inhibited GEP 1; ADP-ribosylation factor guanine nucleotide-exchange factor 1; p200 ARF guanine nucleotide exchange factor; p200 ARF-GEP1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competetive RhoA binding. The function in the nucleus remains to be determined.
  • 基因功能参考文献：
    1. The findings provide structural insight into how Arf1 GEFs, and hence active Arf1, achieve their correct subcellular distribution. PMID: 27373159
    2. The data demonstrate a novel and unexpected function of BIG1 that regulates TNFR1 signaling by targeting TRAF2. PMID: 27834853
    3. BIG1, through its ability to activate ADP-ribosylation factor 1, regulates cell-surface levels and function of ABCA1. PMID: 23220274
    4. BIG1 and KANK1 play roles in regulating cell polarity during directed migration in wound healing. PMID: 22084092
    5. Promoter methylations of CAMK2B and ARFGEF1 are novel epigenetic markers identified in breast cancer cell lines. PMID: 21871176
    6. BIG1 binds to FKBP13, playing a role in vesicular trafficking PMID: 12606707
    7. data are consistent with independent intracellular movements and actions of BIG1 and BIG2, and they are also evidence of the participation of BIG1 in both Golgi and nuclear functions PMID: 14973189
    8. myosin IXb binds to BIG1, which regulates its Rho-GTPase activating protein activity PMID: 15644318
    9. Two critical elements of BIG1 molecular structure were identified, as well as the potential function of microtubules in a novel PKA effect on BIG1 translocation. PMID: 16467138
    10. Two different poliovirus proteins independently recruit different Arf GEFs (GBF1 and BIG1/2) to membranes as part of cellular pathways utilized by the virus to form its membranous replication complex. PMID: 17079330
    11. results indicate a previously unrecognized role for BIG1 in the glycosylation of beta1 by Golgi enzymes, which is critical for its function in developmental and other vital cell processes PMID: 17227842
    12. Evidence that BIG1 and nucleolin, but not fibrillarin, can be present with p62 at the nuclear envelope confirms the presence of BIG1 and nucleolin in dynamic molecular complexes that change in composition while moving through nuclei PMID: 18292223
    13. Overexpression of full-length KIF21A and BIG1 and their fragments in HEK293 cells followed by reciprocal IP revealed that the C-terminal tail of KIF21A, with seven WD-40 repeats, may interact with structure in the C-terminal region of BIG1. PMID: 19020088

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Nucleus. Nucleus, nucleolus. Nucleus matrix. Note=Translocates from cytoplasm to membranes and nucleus upon cAMP treatment.
  • 组织特异性：
    Expressed in placenta, lung, heart, brain, kidney and pancreas.
  • 数据库链接：

    HGNC: 15772

    OMIM: 604141

    KEGG: hsa:10565

    STRING: 9606.ENSP00000262215

    UniGene: Hs.656902

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