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  4. Recombinant Human Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 (NDST3), partial

Recombinant Human Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 (NDST3), partial

  • 中文名称：
    人NDST3重组蛋白
  • 货号：
    CSB-YP015616HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人NDST3重组蛋白
  • 货号：
    CSB-EP015616HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人NDST3重组蛋白
  • 货号：
    CSB-EP015616HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人NDST3重组蛋白
  • 货号：
    CSB-BP015616HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人NDST3重组蛋白
  • 货号：
    CSB-MP015616HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NDST3
  • Uniprot No.：
    O95803
  • 别名：
    NDST3; HSST3; UNQ2544/PRO4998Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3; EC 2.8.2.8; Glucosaminyl N-deacetylase/N-sulfotransferase 3; NDST-3; hNDST-3; N-heparan sulfate sulfotransferase 3; N-HSST 3) [Includes: Heparan sulfate N-deacetylase 3; EC 3.-.-.-); Heparan sulfate N-sulfotransferase 3; EC 2.8.2.-)]
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity.
  • 基因功能参考文献：
    1. Study does not support that the NDST3 gene plays a major role in schizophrenia, bipolar disorder, and major depressive disorder in the Han Chinese population. PMID: 29140583
    2. A genome-wide association study provided suggestive evidence that the NDST3 variation predisposed patients to schizophrenia and bipolar disorder. PMID: 26731438
    3. study provides evidence that the minor allele of rs11098403, an SNP near NDST3, is significantly associated with a reduced risk of schizophrenia in a Han Chinese population, further confirming the data obtained from Caucasians PMID: 25139529
    4. A case-control study evaluating the entire genome for genes associated with the risk of schizophrenia and bipolar disorder demnstrated polymorphisms of NDST3 in case patients. PMID: 24253340
  • 亚细胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Sulfotransferase 1 family, NDST subfamily
  • 组织特异性：
    Expressed in brain, kidney, liver, fetal and adult lung, adult pancreas, placenta, fetal spleen and fetal thymus. Not detected in adult/ fetal heart and skeletal muscle.
  • 数据库链接：

    HGNC: 7682

    OMIM: 603950

    KEGG: hsa:9348

    STRING: 9606.ENSP00000296499

    UniGene: Hs.480596

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