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  4. Recombinant Human BCL-6 corepressor-like protein 1 (BCORL1), partial

Recombinant Human BCL-6 corepressor-like protein 1 (BCORL1), partial

  • 中文名称：
    Recombinant Human BCL-6 corepressor-like protein 1(BCORL1) ,partial
  • 货号：
    CSB-YP683011HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human BCL-6 corepressor-like protein 1(BCORL1) ,partial
  • 货号：
    CSB-EP683011HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human BCL-6 corepressor-like protein 1(BCORL1) ,partial
  • 货号：
    CSB-EP683011HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human BCL-6 corepressor-like protein 1(BCORL1) ,partial
  • 货号：
    CSB-BP683011HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human BCL-6 corepressor-like protein 1(BCORL1) ,partial
  • 货号：
    CSB-MP683011HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    BCORL1
  • Uniprot No.：
    Q5H9F3
  • 别名：
    BCL-6 corepressor-like protein 1; BCL6 co-repressor-like 1; BCL6 corepressor-like 1; BCoR-L1; BCoR-like protein 1; BCORL_HUMAN; BCORL1; CXorf10; FLJ11362; FLJ11632
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor.
  • 基因功能参考文献：
    1. Either endogenous BCORL1 silencing or ectopic BCORL1(Q1076H) expression mimicked the effects of a CRISPR/Cas9-edited BCORL1(Q1076H) locus. PMID: 29605720
    2. Studied the clinical significance of BCORL1 and its role in the metastasis of HCC. PMID: 26879601
    3. BCORL1 knockdown up-regulates E-cadherin expression and subsequently inhibits cell migration and invasion of lung cancer cells. PMID: 26648304
    4. genetic association study in population in Italy: Data suggest BCORL1 mutations/single nucleotide polymorphisms are not associated with leukemic transformation of chronic myeloproliferative neoplasms (MPN) into acute myeloid leukemia (AML). [LETTER] PMID: 23793880
    5. BCORL1 by genetic criteria is a novel candidate tumor suppressor gene, joining the growing list of genes recurrently mutated in acute myelogenous leukemia. PMID: 21989985
    6. Dysregulated BCoR-L1 expression is associated with breast cancer PMID: 17697391

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    BCOR family
  • 组织特异性：
    Detected in testis and prostate. Detected at lower levels in peripheral blood leukocytes and spleen.
  • 数据库链接：

    HGNC: 25657

    OMIM: 300688

    KEGG: hsa:63035

    STRING: 9606.ENSP00000218147

    UniGene: Hs.496748

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