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  4. Recombinant Human Arginine--tRNA ligase, cytoplasmic (RARS)

Recombinant Human Arginine--tRNA ligase, cytoplasmic (RARS)

  • 中文名称：
    人RARS重组蛋白
  • 货号：
    CSB-YP019344HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人RARS重组蛋白
  • 货号：
    CSB-EP019344HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人RARS重组蛋白
  • 货号：
    CSB-EP019344HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人RARS重组蛋白
  • 货号：
    CSB-BP019344HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人RARS重组蛋白
  • 货号：
    CSB-MP019344HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RARS
  • Uniprot No.：
    P54136
  • 别名：
    2610011N19Rik; 2610037E21Rik; AL033339; Arginine tRNA ligase 1, cytoplasmic; Arginine tRNA ligase; Arginine--tRNA ligase; Arginyl tRNA synthetase 1; Arginyl tRNA synthetase cytoplasmic; Arginyl tRNA synthetase, cytoplasmic; Arginyl-tRNA synthetase, cytoplasmic; ArgRS; AW985894; DALRD 1; DALRD1; EC 6.1.1.19; MGC8641; MGC86730; RARS; SYRC_HUMAN; wu:fa96g09; zgc:56050; zgc:86730
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-660
  • 氨基酸序列
    MDVLVSECSA RLLQQEEEIK SLTAEIDRLK NCGCLGASPN LEQLQEENLK LKYRLNILRK SLQAERNKPT KNMINIISRL QEVFGHAIKA AYPDLENPPL LVTPSQQAKF GDYQCNSAMG ISQMLKTKEQ KVNPREIAEN ITKHLPDNEC IEKVEIAGPG FINVHLRKDF VSEQLTSLLV NGVQLPALGE NKKVIVDFSS PNIAKEMHVG HLRSTIIGES ISRLFEFAGY DVLRLNHVGD WGTQFGMLIA HLQDKFPDYL TVSPPIGDLQ VFYKESKKRF DTEEEFKKRA YQCVVLLQGK NPDITKAWKL ICDVSRQELN KIYDALDVSL IERGESFYQD RMNDIVKEFE DRGFVQVDDG RKIVFVPGCS IPLTIVKSDG GYTYDTSDLA AIKQRLFEEK ADMIIYVVDN GQSVHFQTIF AAAQMIGWYD PKVTRVFHAG FGVVLGEDKK KFKTRSGETV RLMDLLGEGL KRSMDKLKEK ERDKVLTAEE LNAAQTSVAY GCIKYADLSH NRLNDYIFSF DKMLDDRGNT AAYLLYAFTR IRSIARLANI DEEMLQKAAR ETKILLDHEK EWKLGRCILR FPEILQKILD DLFLHTLCDY IYELATAFTE FYDSCYCVEK DRQTGKILKV NMWRMLLCEA VAAVMAKGFD ILGIKPVQRM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

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RARS antibodies

靶点详情

  • 功能：
    Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1.
  • 基因功能参考文献：
    1. Missense variant Ser456Leu and a de novo deletion Tyr616Leufs*6 cause disorder akin to Pelizaeus-Merzbacher disease. PMID: 28905880
    2. Data indicate that the N terminus of Pro-EMAP II binds to its C terminus, arginyl-tRNA synthetase, and the neurofilament light subunit. PMID: 25724651
    3. The mRNA of human cytoplasmic arginyl-tRNA synthetase recruits prokaryotic ribosomes independently. PMID: 24898251
    4. report describe 4 patients with hypomyelination and mutations in RARS PMID: 24777941
    5. The crystal structures of the L-arginine-complexed, and L-canavanine-complexed forms of arginyl-tRNA synthetase from Homo sapiens. PMID: 24859084
    6. Hemin binds to human cytoplasmic arginyl-tRNA synthetase and inhibits its catalytic activity PMID: 20923763
    7. leucyl-tRNA synthetase requires its C-terminal domain for its interaction with arginyl-tRNA synthetase in the multi-tRNA synthetase complex PMID: 16055448
    8. RARS over-expression impairs aminoacyl t-RNA synthetase interacting multifunctional protein (AIMP1) secretion by both HeLa and MCF7 cells. PMID: 17443684

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  • 相关疾病：
    Leukodystrophy, hypomyelinating, 9 (HLD9)
  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytosol.
  • 蛋白家族：
    Class-I aminoacyl-tRNA synthetase family
  • 数据库链接：

    HGNC: 9870

    OMIM: 107820

    KEGG: hsa:5917

    STRING: 9606.ENSP00000231572

    UniGene: Hs.654907

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