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  2. 蛋白
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  4. Recombinant Human Antigen peptide transporter 1 (TAP1), partial

Recombinant Human Antigen peptide transporter 1 (TAP1), partial

  • 中文名称：
    人TAP1重组蛋白
  • 货号：
    CSB-YP023120HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人TAP1重组蛋白
  • 货号：
    CSB-EP023120HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人TAP1重组蛋白
  • 货号：
    CSB-EP023120HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人TAP1重组蛋白
  • 货号：
    CSB-BP023120HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人TAP1重组蛋白
  • 货号：
    CSB-MP023120HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TAP1
  • Uniprot No.：
    Q03518
  • 别名：
    ABC 17; ABC transporter MHC 1; ABC17; ABCB 2; ABCB2; Antigen peptide transporter 1; APT 1; APT1; ATP binding cassette sub family B (MDR/TAP) member 2; ATP binding cassette sub family B member 2; ATP binding cassette transporter; ATP-binding cassette sub-family B member 2; D6S114E; FLJ26666; FLJ41500; Peptide supply factor 1; Peptide transporter involved in antigen processing 1; Peptide transporter PSF 1; Peptide transporter PSF1; Peptide transporter TAP 1; Peptide transporter TAP1; PSF 1; PSF-1; PSF1; Really interesting new gene 4 protein; RING 4; RING4; TAP 1; TAP1; TAP1*0102N; TAP1_HUMAN; TAP1N; Transporter 1 ATP binding cassette sub family B (MDR/TAP); Transporter 1 ATP binding cassette sub family B; Transporter associated with antigen processing; Transporter ATP binding cassette major histocompatibility complex 1; Y3
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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TAP1 antibodies

靶点详情

  • 功能：
    ABC transporter associated with antigen processing. In complex with TAP2 mediates unidirectional translocation of peptide antigens from cytosol to endoplasmic reticulum (ER) for loading onto MHC class I (MHCI) molecules. Uses the chemical energy of ATP to export peptides against the concentration gradient. During the transport cycle alternates between 'inward-facing' state with peptide binding site facing the cytosol to 'outward-facing' state with peptide binding site facing the ER lumen. Peptide antigen binding to ATP-loaded TAP1-TAP2 induces a switch to hydrolysis-competent 'outward-facing' conformation ready for peptide loading onto nascent MHCI molecules. Subsequently ATP hydrolysis resets the transporter to the 'inward facing' state for a new cycle. Typically transports intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome. Binds peptides with free N- and C-termini, the first three and the C-terminal residues being critical. Preferentially selects peptides having a highly hydrophobic residue at position 3 and hydrophobic or charged residues at the C-terminal anchor. Proline at position 2 has the most destabilizing effect. As a component of the peptide loading complex (PLC), acts as a molecular scaffold essential for peptide-MHCI assembly and antigen presentation.
  • 基因功能参考文献：
    1. Our finding suggested that TAP1-rs1135216, TAP1-rs4148873, TAP2-rs2228396, TAP2-rs241447 and TAP2-rs4148873 might not be involved in cancer risk, but the T allele of TAP2-rs4148876 might be a potential biomarker for judging cancer risk [review, meta-analysis] PMID: 30082158
    2. In a meta-analyses of 6 studies with 415 cases and 659 controls, a significant association was found between TAP1-333Val, TAP1-637Gly, and TAP2-565Thr and ankylosing spondylitis compared with combined control group. PMID: 28405734
    3. Both TAP1 and TAP2 overexpression in breast cancer might be an indicator of an aggressive breast tumor PMID: 29091951
    4. The structure shows that herpes simplex virus ICP47 traps human TAP in an inactive conformation distinct from the normal transport cycle. PMID: 27935481
    5. PSMB8 rs2071464 was associated with generalized and active vitiligo from Gujarat whereas TAP1 rs1135216 showed no association. The down-regulation of PSMB8 in patients with risk genotype 'CC' advocates the vital role of PSMB8 in the autoimmune basis of vitiligo. PMID: 28700671
    6. Study compared the biochemical properties of the nucleotide-binding domains (NBD) of human and rat TAP1; suggests that although the D-helix sequence is not conserved in ABC transporters, its precise positioning within the NBD structure has a critical role in NBD dimerization. PMID: 28542489
    7. Significant associations between sorafenib exposure and the studied polymorphisms were observed for ABCB2 PMID: 28289864
    8. this study shows that TAP1 plays a novel role in the negative regulation of virus-triggered NF-kappaB signaling and the innate immune response by targeting the TAK1 complex PMID: 28356387
    9. there was no significant difference with respect to the genotypic frequencies of the SNPs in PSMB8, TAP1, and TAP2 loci in Parkinson's disease patients PMID: 27098790
    10. The disruption of TAP1 and TAPBP generates pluripotent embryonic stem cells with reduced immunogenicity. PMID: 27068360
    11. TAP1/2 gene polymorphisms might be associated with pulmonary tuberculosis susceptibility among patients in Zahedan, southeast Iran. PMID: 26996113
    12. The results suggest an association between a TAP1 promoter SNP (rs2071480) and susceptibility to alopecia areata in a Korean population. PMID: 26782532
    13. IFNalpha upregulates TAP1 expression in peripheral blood mononuclear cells (PBMCs) of patients with malignant melanoma receiving adjuvant high-dose immunotherapy. PMID: 26735690
    14. cryo-electron microscopy structure of human TAP in complex with its inhibitor ICP47, a small protein produced by the herpes simplex virus I PMID: 26789246
    15. this ultrasensitive method for the first time permits quantification of TAP activity under close to physiological conditions in scarce primary cell subsets such as antigen cross-presenting dendritic cells. PMID: 25656091
    16. PSF1 expression correlates with a more aggressive phenotype as well as worse prognosis in hepatocellular carcinoma patients. PMID: 25198552
    17. PSF1 is expressed in high-grade prostate cancer and may be a useful biomarker to identify patients with a poor prognosis at the time of diagnosis PMID: 25403418
    18. Studies indicate that ABC transporters associated with antigen processing TAP1/2 (ABCB2/3) is a crucial element of the adaptive immune system. PMID: 24923865
    19. None of TAP1 alleles showed a signi fi cant di ff erence in phenotype frequency between pulmonary tuberculosis and controls, and among subgroups of pulmonary tuberculosis. PMID: 25846714
    20. The TAP1-rs1135216 and PSMB9-rs17587 variants are significantly associated with vitiligo, and even one copy of these mutant alleles can influence the risk among Saudis. PMID: 25548428
    21. PSF1 was overexpressed in lung cancer. PMID: 25398693
    22. TAP1 I333V gene polymorphism was significantly associated with increased type 1 diabetes mellitus risk. PMID: 24655325
    23. Participants with a mutated allele had an increased risk for CRC. The adjusted odds ratios for the C/T, T/T, and the mutation type (C/T + T/T) compared to that of wild type (C/C) were 2.27, 1.95, and 2.22 respectively. PMID: 24803408
    24. Results suggested an association of TAP1-333 polymorphism with multiple myeloma. PMID: 24175803
    25. TAP1 AND TAP2 polymorphisms are associated with a reduced risk for developing cervical intraepithelial neoplasia. PMID: 24288424
    26. In this study, we map the respective binding site in TAP1 to the polar face of the amphipathic TM helix TM9 and identify key residues that are essential to establish the interaction. PMID: 24501197
    27. Cif is the first bacterial factor identified that inhibits TAP1 function and MHC class I antigen presentation PMID: 24247241
    28. We observed significantly higher prevalence of Ile333Ile TAP1 allele in patients whose first-degree relatives had a positive family history of psoriasis. PMID: 23834030
    29. TAP1-TAP2 NBD dimers are not fully stabilized by nucleotides alone, and substrate binding plays a key role in inducing the transition state conformations of the NBD. PMID: 24196954
    30. The TAP-1 p.697Gly allele in donors was associated with increased incidence of early acute cellular rejection following living-donor liver transplantation. PMID: 23799215
    31. the TAP1 gene variant (rs1135216 Asp637Gly) influences the susceptibility to clinically classified leprosy patients in Indian population. PMID: 23395648
    32. The degree of differentiation of hepatocellular carcinoma was correlated with TNF-alpha expression (p<0.05), but not TAP1 expression (p>0.05). PMID: 23682387
    33. Preprocalcitonin (ppCT16-25) human tumor epitope requires low TAP expression for efficient presentation. PMID: 23302073
    34. TAP1 is a downstream target gene of SHH signaling pathway PMID: 23340176
    35. There was no association of TAP1 * rs1057141, rs1135216 gene G allele and allergic rhinitis in the Xinjiang Han people. PMID: 23272491
    36. The results suggest that TAP1 and TAP2 gene polymorphisms are associated with not only the susceptibility to hepatitis B virus infection, but also with inflammation progress, advanced fibrogenesis and cancer development. PMID: 22989262
    37. TAP1 methylation is significantly associated with cervical HPV infection in Uyghur women. PMID: 22932452
    38. the N-terminal extension of the TAP1 subunit represents an autonomous domain, which is correctly targeted to and inserted into the endoplasmic reticulum membrane PMID: 22638925
    39. X-ray diffraction data sets were collected for apo and complexed ATPase domain of human TAP1 using an in-house X-ray diffraction facility at a wavelength of 1.5418 A PMID: 22684063
    40. The data suggest that patients with low or defective TAP1 or calnexin in primary breast cancers may be at higher risks for developing brain metastasis due to the defects in T cell-based immunosurveillance. PMID: 22065046
    41. Role of metalloproteases in vaccinia virus epitope processing for transporter associated with antigen processing (TAP)-independent human leukocyte antigen (HLA)-B7 class I antigen presentation. PMID: 22298786
    42. TAP1 polymorphisms showed no relations to both AERD and FEV1 decline after aspirin challenge (P>0.05). PMID: 21796142
    43. Six vaccinia virus ligands were presented by HLA-B51 and/or HLA-Cw1 class I molecules in human TAP-deficient cells. PMID: 22031944
    44. The unfolded protein response (UPR)-activated transcription factor X-box-binding protein 1 (XBP1) induces microRNA-346 expression that targets the human antigen peptide transporter 1 (TAP1) mRNA and governs immune regulatory genes. PMID: 22002058
    45. The GG genotype at TAP1 position 333 and GA genotype at TAP1 position 637 are positively associated with HIV-TB co-infection and these genotypes may act as a risk factor for developing TB co-infection in HIV-positive individuals. PMID: 21843574
    46. Allele-dependent processing pathways generate the endogenous human leukocyte antigen (HLA) class I peptide repertoire in transporters associated with antigen processing (TAP)-deficient cells PMID: 21914809
    47. ppCT(16-25) is the first human tumor epitope whose surface expression requires loss or downregulation of TAP PMID: 22025554
    48. tap1*0101 and tap2*0101 are most common alleles in Chinese Hans. PMID: 19549407
    49. HLA-I, TAP1, CNX, LMP7, Erp57, Tapasin and ERAP1 were down-regulated in 68%, 44%, 48%, 40%, 52%, 32% and 20% of esophageal squamous cell carcinoma lesions then, respectively. PMID: 21362330
    50. TAP is localized to the ERGIC (ER-Golgi intermediate compartment) and the Golgi of both fibroblasts and lymphocytes. PMID: 21098634

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  • 相关疾病：
    Bare lymphocyte syndrome 1 (BLS1)
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=The transmembrane segments seem to form a pore in the membrane.
  • 蛋白家族：
    ABC transporter superfamily, ABCB family, MHC peptide exporter (TC 3.A.1.209) subfamily
  • 组织特异性：
    Higly expressed in professional APCs monocytes and dendritic cells as well as in lymphocyte subsets T cells, B cells and NK cells.
  • 数据库链接：

    HGNC: 43

    OMIM: 170260

    KEGG: hsa:6890

    STRING: 9606.ENSP00000346206

    UniGene: Hs.352018

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