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  4. Recombinant Human Ankyrin-1 (ANK1), partial

Recombinant Human Ankyrin-1 (ANK1), partial

  • 中文名称：
    Recombinant Human Ankyrin-1(ANK1) ,partial
  • 货号：
    CSB-YP001720HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Ankyrin-1(ANK1) ,partial
  • 货号：
    CSB-EP001720HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Ankyrin-1(ANK1) ,partial
  • 货号：
    CSB-EP001720HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Ankyrin-1(ANK1) ,partial
  • 货号：
    CSB-BP001720HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Ankyrin-1(ANK1) ,partial
  • 货号：
    CSB-MP001720HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ANK1
  • Uniprot No.：
    P16157
  • 别名：
    ANK; ANK-1; Ank1; ANK1_HUMAN; Ankyrin 1; Ankyrin 1; erythrocytic; Ankyrin R; Ankyrin-1; Ankyrin-R; Erythrocyte ankyrin; SPH1; SPH2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions.; Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils.
  • 基因功能参考文献：
    1. Our finding suggested that a de novo nonsense mutation in ANK1 may be causative to HS which plays an important role in supplementing the mutational spectrum of the ANK1 and explaining the mechanism of HS. PMID: 29099659
    2. ANK1 rs508419-C type 2 diabetes (T2D)-risk allele alters DNA-protein complex binding leading to increased promoter activity and sAnk1 expression; thus, increased sAnk1 expression in skeletal muscle might contribute to T2D susceptibility. PMID: 27121283
    3. rs515071 in ANK1 is a novel genetic risk for late-onset Alzheimer's disease susceptibility in Han Chinese. PMID: 26611832
    4. The present study demonstrates that ANK1 is aberrantly expressed in pancreatic adenocarcinomas in association with promoter hypomethylation PMID: 27144336
    5. Transient Receptor Potential Vanniloid-1 channel (TRPV-1) has a role in the cough reflex and airway expression is increased in patients with chronic cough. The Ankyrin-1 receptor (TRPA-1) is often co-expressed PMID: 29149168
    6. Aberrant ANK1 methylation is highly prevalent in lung cancer, discriminate tumors by histology and patients' smoking history, and contributes to miR-486-5p repression. PMID: 28965852
    7. Study shows that Ankyrin-1 forms a high-affinity interaction with AE1 tetramers but does not associate with AE1 dimers in erythrocyte membranes. PMID: 27989623
    8. ANK1 is up-regulated 4-fold in Alzheimer disease microglia, but not in neurons or astrocytes from the same individuals. PMID: 28700589
    9. Two novel mutations in ANK1 (Y216X and E142X) are responsible for hereditary spherocytosis. PMID: 28694211
    10. These results suggest that sAnk1 interacts with SLN both directly and in complex with SERCA1 and reduces SLN's inhibitory effect on SERCA1 activity. PMID: 28487373
    11. Mutational characteristics of ANK1 and SPTB genes in Korean hereditary spherocytosis have been described. PMID: 26830532
    12. Ankyrin-1 is induced to a greater extent than the embedded miRNA following DNA damage. PMID: 27054339
    13. analysis of a novel p.Q1772X ANK1 mutation in a Korean family with hereditary spherocytosis [case report of two family members] PMID: 26107955
    14. The study reports the refinement for a protein heterodimer complex using limited EPR spectroscopic data and a rigid-body docking algorithm: a three-dimensional model for an ankyrin 1-BND3 complex. PMID: 24758720
    15. A novel L1340P mutation in the ANK1 gene is associated with hereditary spherocytosis. PMID: 24903897
    16. We identified a differentially methylated region in the ankyrin 1 (ANK1) gene that was associated with neuropathology in the entorhinal cortex, a primary site of Alzheimer disease manifestation. PMID: 25129077
    17. ANK1 rs516946 confers impaired insulin release. PMID: 23457408
    18. The ankyrin-binding site on band 3 is located near the deoxygenated hemoglobin-binding site, therefore following deoxygenation ankyrin is displaced from band 3. PMID: 23013433
    19. A tissue-specific chromatin loop brings NF-E2 and ANK1E into close proximity preventing gene silencing and mutagenesis leading to hereditary spherocytosis. PMID: 22968456
    20. results indicate that the ANK1 locus is a new, common susceptibility locus for type 2 diabetes across different ethnic groups PMID: 22456796
    21. The interaction of KCTD6 with ankyrin-1 may have implications beyond muscle for hereditary spherocytosis, as KCTD6 is also present in erythrocytes, and erythrocyte ankyrin isoforms contain its mapped minimal binding site. PMID: 22573887
    22. Determination of structural models of the complex between the cytoplasmic domain of erythrocyte band 3 and ankyrin-R repeats 13-24. PMID: 21493712
    23. The Hereditary Spherocytosis mutation in the human Ankyrin-1 promoter disrupted the binding of the transcription factor TFIID, the major component of the pre-initiation complex. PMID: 21071415
    24. cytoskeletal ankyrin family are substrates for FIH-catalyzed hydroxylations PMID: 21177872
    25. a region upstream of the promoter is a barrier insulator. The region exhibited functional and structural characteristics of a barrier, including prevention of gene silencing, appropriate chromatin configuration and occupancy by barrier-associated proteins PMID: 21099109
    26. Generated a library of more than 16,000 ANK-1 promoters with degenerate sequence around the dinucleotide deletion mutation and cloned the functional promoter sequences. Identified the wild type and three additional sequences, and derived a consensus. PMID: 20479128
    27. ankyrin and protein 4.1 are cleaved by native and recombinant falcipain-2 near their C-termini PMID: 12130521
    28. interaction of hydrophilic domain with two N-terminal immunoglobulin domains of titin PMID: 12444090
    29. identification of ankyrin as a target of spectrin's E2/E3 activity PMID: 15040428
    30. The interactions of three protein 4.2-derived recombinant proteins with CDB3 and ankyrin were investigated by using Far-Western blot and pull-down assay. PMID: 16718373
    31. off rates of the band 3-ankyrin interaction are sufficiently slow to allow sustained erythrocyte deformation without loss of elasticity PMID: 16762928
    32. Allelic and genotypic frequencies were similar in both studied groups for the G199A and Memphis I polymorphismsin Hereditary Spherocytosis among the Mexican population. PMID: 17128827
    33. It was shown that the region within beta-spectrin involved in interactions with ankyrin includes a lipid-binding site and binding is inhibited by ankyrin. Our results shows: the ankyrin-sens. lipid-bind. site of beta-spectrin exhibits a helical conform. PMID: 17520478
    34. Our results therefore indicate the importance of N-terminal region for lipid-binding activity of the beta-spectrin ankyrin-binding domain and its substantial role in maintaining the spectrin-based skeleton distribution. PMID: 17716929
    35. Structural and mutational studies of the binding region on small Ank1 for obscurin suggest that it consists of two ankyrin repeats with very similar structures. PMID: 17720975
    36. Ankyrin facilitates intracellular trafficking of alpha1-Na+-K+-ATPase in polarized cells. PMID: 18768923
    37. A small muscle-specific isoform of the ANK1 gene, ank1.5, interacts with obscurin. Since ank1.5 is localised on the sarcoplasmic reticulum and obscurin on the myofibrils, these two proteins may provide a molecular link between these subcellular regions. PMID: 12527750

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  • 相关疾病：
    Spherocytosis 1 (SPH1)
  • 亚细胞定位：
    [Isoform Er1]: Cytoplasm, cytoskeleton. Note=Probably the other erythrocyte (Er) isoforms, are located near the surface of erythrocytic plasma membrane.; [Isoform Mu17]: Membrane. Cytoplasm, myofibril, sarcomere, M line. Note=Colocalizes with OBSCN isoform 3/obscurin at the M line in differentiated skeletal muscle cells.; [Isoform Mu18]: Sarcoplasmic reticulum.; [Isoform Mu19]: Sarcoplasmic reticulum.; [Isoform Mu20]: Sarcoplasmic reticulum.
  • 组织特异性：
    Isoform Mu17, isoform Mu18, isoform Mu19 and isoform Mu20 are expressed in skeletal muscle. Isoform Br21 is expressed in brain.
  • 数据库链接：

    HGNC: 492

    OMIM: 182900

    KEGG: hsa:286

    STRING: 9606.ENSP00000265709

    UniGene: Hs.654438

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