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  4. Recombinant Human Activating transcription factor 7-interacting protein 1 (ATF7IP), partial

Recombinant Human Activating transcription factor 7-interacting protein 1 (ATF7IP), partial

  • 中文名称：
    Recombinant Human Activating transcription factor 7-interacting protein 1(ATF7IP) ,partial
  • 货号：
    CSB-YP747655HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Activating transcription factor 7-interacting protein 1(ATF7IP) ,partial
  • 货号：
    CSB-EP747655HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Activating transcription factor 7-interacting protein 1(ATF7IP) ,partial
  • 货号：
    CSB-EP747655HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Activating transcription factor 7-interacting protein 1(ATF7IP) ,partial
  • 货号：
    CSB-BP747655HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Activating transcription factor 7-interacting protein 1(ATF7IP) ,partial
  • 货号：
    CSB-MP747655HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ATF7IP
  • Uniprot No.：
    Q6VMQ6
  • 别名：
    ATF7IP; MCAF; MCAF1Activating transcription factor 7-interacting protein 1; ATF-interacting protein; ATF-IP; ATF7-interacting protein; ATFa-associated modulator; hAM; MBD1-containing chromatin-associated factor 1; P621
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells.
  • 基因功能参考文献：
    1. Here we report on a special case of a Ph-like acute lymphoblastic leukemia patient who had a variant ATF7IP/PDGFRB fusion. In this case, a variant fusion was created between ATF7IP exon 9 (instead of exon 13) and PDGFRB exon 11, resulting in the loss of 411 nucleotides and 137 amino acids in the ATF7IP/PDGFRB fusion cDNA and its encoded chimeric protein, respectively. PMID: 29133777
    2. these data identify a critical functional role for ATF7IP in heterochromatin formation by regulating SETDB1 abundance in the nucleus. PMID: 27732843
    3. results indicate that ATF7IP does not directly modulate SETDB1 catalytic activity, suggesting alternate roles, such as affecting cellular localization or mediating interaction with additional binding partners. PMID: 26813693
    4. these results indicate a critical role for MCAF1 in AP-1-dependent Rta activation of BZLF1 transcription. PMID: 24598729
    5. We demonstrated the importance of Aire's interaction with the ATF7ip-MBD1 protein complex in maintaining central tolerance PMID: 24464130
    6. The transcriptional cofactor MCAF1/ATF7IP is involved in histone gene expression and cellular senescence. PMID: 23935871
    7. Genetic variants at ATF7IP and KLK2 contribute to the variance of %fPSA. PMID: 23359319
    8. Studies identified three new susceptibility loci DMRT1, TERT and ATF7IP associated with testicular germ cell cancer. PMID: 20543847
    9. mAM/hAM facilitates conversion of H3-K9 dimethyl to trimethyl by ESET/SETDB1 PMID: 14536086
    10. These data suggest that MBD1.MCAF1.SETDB1 complex facilitates the formation of heterochromatic domains, emphasizing the role of MCAF/AM family proteins in epigenetic control, and describe a new family member, MCAF2. PMID: 15691849
    11. MBD1- and MCAF1-mediated heterochromatin formation involves SUMO modification PMID: 16757475
    12. the acidic stretch of the SIM of MCAF1 plays an important role in the binding to SUMO-3. PMID: 18842587
    13. Two evolutionarily conserved domains of MCAF1 directly interact with Sp1 and the general transcriptional apparatus. Selective depletion of MCAF1 or Sp1 down-regulates TERT and TERC genes in cultured cells, which results in decreased telomerase activity. PMID: 19106100

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    MCAF family
  • 组织特异性：
    Detected at low levels in breast, lung and stomach; highly up-regulated in the corresponding cancerous tissues (at protein level).
  • 数据库链接：

    HGNC: 20092

    OMIM: 613644

    KEGG: hsa:55729

    STRING: 9606.ENSP00000261168

    UniGene: Hs.504856

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