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  4. Recombinant Human Actin-binding protein anillin (ANLN), partial

Recombinant Human Actin-binding protein anillin (ANLN), partial

  • 中文名称：
    Recombinant Human Actin-binding protein anillin(ANLN) ,partial
  • 货号：
    CSB-YP865109HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Actin-binding protein anillin(ANLN) ,partial
  • 货号：
    CSB-EP865109HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Actin-binding protein anillin(ANLN) ,partial
  • 货号：
    CSB-EP865109HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Actin-binding protein anillin(ANLN) ,partial
  • 货号：
    CSB-BP865109HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Actin-binding protein anillin(ANLN) ,partial
  • 货号：
    CSB-MP865109HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ANLN
  • Uniprot No.：
    Q9NQW6
  • 别名：
    Actin binding protein scraps homolog Drosophila; Actin binding protein anillin; Actin-binding protein anillin; Anillin actin binding protein; anln; ANLN_HUMAN; DKFZp779A055; FSGS8; Scra; Scraps; Scraps homolog
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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ANLN antibodies

靶点详情

  • 功能：
    Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis. May play a significant role in podocyte cell migration.
  • 基因功能参考文献：
    1. Bladder urothelial carcinoma patients with elevated ANLN expression had poorer survival prospects. PMID: 28600503
    2. Knockdown of ANLN in liver cells blocks cytokinesis and inhibits development of liver tumors. PMID: 29274368
    3. Authors found that decreasing Ran-GTP levels or tethering active Ran to the equatorial membrane affects anillin's localization and causes cytokinesis phenotypes. PMID: 28931593
    4. Anillin (ANLN) expression in tumor cells is correlated to poor prognosis in breast cancer patients, independent of Ki-67 or tumor size. PMID: 27863473
    5. S635 phosphorylation is essential for cytokinesis. PMID: 28081137
    6. ANLN expression is elevated in colorectal cancer and has a strong potential to act as a biomarker for the prognosis of colorectal cancer. PMID: 27062703
    7. Findings indicate that miR-497 is a potent tumor suppressor that inhibits cancer phenotypes by targeting ANLN and HSPA4L in NPC. PMID: 26486082
    8. High nuclear expression of anillin (ANLN) is an independent predictor of poor disease-specific survival and it is a useful prognostic marker of urothelial carcinoma of the upper urinary tract (UCUT). PMID: 26135313
    9. Data suggest that anillin (ANLN) could be involved in breast cancer progression and a potential target candidate in breast cancer. PMID: 25223638
    10. Identification 4 novel and 18 known exonic ANLN variants associated with carotid intima-media thickness at bifurcation. PMID: 26319989
    11. Anillin regulates intercellular adhesion in model human epithelia by mechanisms involving the suppression of JNK activity and controlling the assembly of the perijunctional cytoskeleton. PMID: 25809162
    12. The sequestration of anillin by astral microtubules might alter the organization of cortical proteins to polarize cells for cytokinesis PMID: 24994938
    13. these data demonstrate that a complex of p190RhoGAP-A and anillin modulates RhoA-GTP levels in the cytokinetic furrow to ensure progression of cytokinesis. PMID: 25359885
    14. Identified a missense mutation R431C in anillin (ANLN), an F-actin binding cell cycle gene, as a cause of FSGS. We screened 250 additional families with FSGS and found another variant, G618C, that segregates with disease in a second family with FSGS. PMID: 24676636
    15. ANLN is positively associated with Wnt/beta-catenin signaling in gastric cancer.Elevated expression of ANLN is a predictor of intestinal type gastric cancer. ER-alpha is negatively associated with the expression of ANLN in gastric cancer. PMID: 24809965
    16. Supervillin concentrates activated and total myosin II at the furrow, and simultaneous knockdown of supervillin and anillin additively increases cell division failure. PMID: 24088567
    17. Antibody screening revealed 3 candidate prognostic markers in breast cancer: the Anillin (ANLN); PDZ-Binding Kinase (PBK); and, PDZ-Domain Containing 1 (PDZK1). PMID: 23547718
    18. Data supports an analogous function for the anillin-Ect2 complex in human cells and one hypothesis is that this complex has functionally replaced the Drosophila anillin-RacGAP50C complex. PMID: 22514687
    19. CIT-K is capable of physically and functionally interacting with the actin-binding protein anillin. PMID: 21849473
    20. Cytoplasmic anillin expression is a marker of favourable prognosis in renal cell carcinoma patients. PMID: 21109967
    21. This study was to establish if ANLN was a molecular marker for pancreatic cancer. PMID: 19995712
    22. anillin has a role in spatially regulating the contractile activity of myosin II during cytokinesis PMID: 15496454
    23. Anillin is a substrate of APC/C that controls spatial contractility of myosin during late cytokinesis. PMID: 16040610
    24. anillin is overexpressed in diverse common human tumors, but not simply because of its role in cell proliferation PMID: 16203764
    25. Over-expression of ANLN is associated with pulmonary carcinogenesis PMID: 16357138
    26. Human anillin contains a conserved C-terminal domain that is essential for its function and localization. PMID: 18158243

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  • 相关疾病：
    Focal segmental glomerulosclerosis 8 (FSGS8)
  • 亚细胞定位：
    Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cell projection, bleb. Note=Mainly found in the nucleus during interphase. Colocalizes with cortical F-actin upon nuclear envelope breakdown in mitosis and subsequently concentrates in the area of the prospective contractile ring in anaphase. This pattern persists until telophase, when the protein becomes concentrated in the midbody.
  • 组织特异性：
    Ubiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart, kidney, liver, lung, pancreas, prostate and
  • 数据库链接：

    HGNC: 14082

    OMIM: 616027

    KEGG: hsa:54443

    STRING: 9606.ENSP00000265748

    UniGene: Hs.62180

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