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  4. Recombinant Human AT-rich interactive domain-containing protein 2 (ARID2), partial

Recombinant Human AT-rich interactive domain-containing protein 2 (ARID2), partial

  • 中文名称：
    Recombinant Human AT-rich interactive domain-containing protein 2(ARID2) ,partial
  • 货号：
    CSB-YP734651HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human AT-rich interactive domain-containing protein 2(ARID2) ,partial
  • 货号：
    CSB-EP734651HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human AT-rich interactive domain-containing protein 2(ARID2) ,partial
  • 货号：
    CSB-EP734651HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human AT-rich interactive domain-containing protein 2(ARID2) ,partial
  • 货号：
    CSB-BP734651HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human AT-rich interactive domain-containing protein 2(ARID2) ,partial
  • 货号：
    CSB-MP734651HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ARID2
  • Uniprot No.：
    Q68CP9
  • 别名：
    ARID domain containing protein 2; ARID domain-containing protein 2; ARID2; ARID2_HUMAN; AT rich interactive domain 2 (ARID; RFX like); AT rich interactive domain containing protein 2; AT-rich interactive domain-containing protein 2; BAF; BAF200; BRG1 associated factor 200; BRG1-associated factor 200; DKFZp686G052; DKFZp779P0222; FLJ30619; KIAA1557; p200; Zinc finger protein with activation potential; zip zap; zipzap; Zipzap/p200
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes.
  • 基因功能参考文献：
    1. We present a 4-year-old girl with delayed neuromotor development, short stature of prenatal onset, and specific behavioral and craniofacial features harboring an intragenic deletion in the ARID2 gene. The phenotype confirmed the major features of the recently described ARID2-related intellectual disability syndrome. PMID: 28884947
    2. These findings highlight the potential role of ARID2 as a tumor growth suppressor in hepatocellular carcinoma PMID: 27351279
    3. ARID2 knockout could contribute to disruption of DNA repair process. PMID: 28238438
    4. study identifies mutations in the ARID2 gene as a novel and rare cause for a CSS-like phenotype and enlarges the list of CSS-like genes PMID: 28124119
    5. Baf200 and Rad51 are present in the same complex and that this interaction is mediated by C-terminal sequences in both proteins. PMID: 28381560
    6. Results show that ARID2 is a direct target of miR155 in human hepatocellular carcinoma (HCC). Alterations of ARID2 expression abrogated the effects of miR155 on HCC cell proliferation, cell cycle and apoptosis. PMID: 27035278
    7. This is the first report of mutations in ARID2 associated with developmental delay and intellectual disabilities . PMID: 26238514
    8. Arid2 role in genome-wide transcriptional regulation by SWI/SNF complexes. PMID: 26716708
    9. loss of ARID2 protein expression may be associated with recurrence of hepatocellular carcinoma PMID: 25701229
    10. Mutations in ARID2 gene is associated with microsatellite unstable colorectal cancer. PMID: 24382590
    11. Recurrent inactivating mutations of ARID2 is associated with non-small cell lung carcinoma. PMID: 23047306
    12. we summarize the current knowledge about the relevance of ARID2 in Hepatocellular carcinoma and the implication in future patient care PMID: 22095441
    13. 18.2% of individuals with HCV-associated HCC in the United States and Europe harbored ARID2 inactivation mutations, suggesting that ARID2 is a tumor suppressor gene that is relatively commonly mutated in this tumor subtype. PMID: 21822264
    14. zipzap may serve as a transcription co-activator for the regulation of cardiac gene expression PMID: 16782067

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Highly expressed in heart.
  • 数据库链接：

    HGNC: 18037

    OMIM: 609539

    KEGG: hsa:196528

    STRING: 9606.ENSP00000335044

    UniGene: Hs.317304

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