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  4. Recombinant Human 5'-3' exoribonuclease 1 (XRN1), partial

Recombinant Human 5'-3' exoribonuclease 1 (XRN1), partial

  • 中文名称：
    人XRN1重组蛋白
  • 货号：
    CSB-YP812907HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人XRN1重组蛋白
  • 货号：
    CSB-EP812907HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人XRN1重组蛋白
  • 货号：
    CSB-EP812907HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人XRN1重组蛋白
  • 货号：
    CSB-BP812907HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人XRN1重组蛋白
  • 货号：
    CSB-MP812907HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    XRN1
  • Uniprot No.：
    Q8IZH2
  • 别名：
    XRN1; SEP1; 5'-3' exoribonuclease 1; EC 3.1.13.-; Strand-exchange protein 1 homolog
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA. Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS).
  • 基因功能参考文献：
    1. Authors use a series of assays to demonstrate that the 3'-terminal portion of the nucleocapsid (N) mRNA of Rift Valley fever virus can effectively stall and repress XRN1. The region responsible for impeding XRN1 includes a G-rich portion that likely forms a G-quadruplex structure. The 3'-terminal portions of ambisense-derived transcripts of multiple arenaviruses also stalled XRN1. PMID: 29118186
    2. Insertion of 5'-3' exoribonuclease 1 (XRN1)-resistant sequences (xrRNAs) into different reporter mRNAs allowed to monitor RNA decay activity by the nonsense-mediated mRNA decay pathway (NMD). PMID: 27917860
    3. These findings suggest that sequestration of the exoribonucleases DIS3L2 and XRN1 to nuclear inclusions may be related to the pathogenesis of intranuclear inclusion body disease PMID: 29100804
    4. Data show that the AR-miR-204-XRN1-miR-34a positive feedback loop and a dual function of miR-204/XRN1 axis in prostate cancer. PMID: 25797256
    5. Thus, Xrn1 is a cellular factor regulating dsRNA accumulation and dsRNA-responsive innate immune effectors. PMID: 25766294
    6. Occupation of each miR-122 binding site on 5' untranslated region of the hepatitis C virus genome contributes equally and cooperatively to virus replication via protecting from Xrn1 exoribonuclease degradation. PMID: 25855736
    7. Authors conclude that Xrn1 is the dominant 5' exoribonuclease mediating decay of hepatitis C virus RNA and that miR-122 provides protection against it PMID: 25673723
    8. Mouse Xrn1 plays a role in RNA turnover. PMID: 9049243
    9. Data show that 5' exonuclease Xrn1 knockdown and miR-122 supplementation have equal, redundant, and nonadditive effects on the rate of viral RNA decay, indicating that miR-122 protects HCV RNA from 5' decay. PMID: 23248316
    10. findings reveal a role for XRN1 in decapping and provide a molecular basis for the coupling of decapping to 5'-->3' mRNA degrada PMID: 23142987
    11. LSm1-7 proteins colocalize with DCP1,DCP2 and Xrn1 in cytoplasmic foci PMID: 12515382

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  • 亚细胞定位：
    Cytoplasm. Note=Discrete foci at the inner surface of the cell membrane.
  • 蛋白家族：
    5'-3' exonuclease family
  • 组织特异性：
    Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and primary cell lines.
  • 数据库链接：

    HGNC: 30654

    OMIM: 607994

    KEGG: hsa:54464

    STRING: 9606.ENSP00000264951

    UniGene: Hs.435103

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