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  4. Recombinant Human 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 (OGFOD1)

Recombinant Human 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 (OGFOD1)

  • 中文名称：
    人OGFOD1重组蛋白
  • 货号：
    CSB-YP847635HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人OGFOD1重组蛋白
  • 货号：
    CSB-EP847635HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人OGFOD1重组蛋白
  • 货号：
    CSB-EP847635HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人OGFOD1重组蛋白
  • 货号：
    CSB-BP847635HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人OGFOD1重组蛋白
  • 货号：
    CSB-MP847635HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    OGFOD1
  • Uniprot No.：
    Q8N543
  • 别名：
    2 oxoglutarate and iron dependent oxygenase domain containing 1; 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1; FLJ10826; KIAA1612; OGFD1_HUMAN; OGFOD1; Termination and polyadenylation 1 homolog; TPA1; TPA1 termination and polyadenylation 1 homolog
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-542
  • 氨基酸序列
    MNGKRPAEPG PARVGKKGKK EVMAEFSDAV TEETLKKQVA EAWSRRTPFS HEVIVMDMDP FLHCVIPNFI QSQDFLEGLQ KELMNLDFHE KYNDLYKFQQ SDDLKKRREP HISTLRKILF EDFRSWLSDI SKIDLESTID MSCAKYEFTD ALLCHDDELE GRRIAFILYL VPPWDRSMGG TLDLYSIDEH FQPKQIVKSL IPSWNKLVFF EVSPVSFHQV SEVLSEEKSR LSISGWFHGP SLTRPPNYFE PPIPRSPHIP QDHEILYDWI NPTYLDMDYQ VQIQEEFEES SEILLKEFLK PEKFTKVCEA LEHGHVEWSS RGPPNKRFYE KAEESKLPEI LKECMKLFRS EALFLLLSNF TGLKLHFLAP SEEDEMNDKK EAETTDITEE GTSHSPPEPE NNQMAISNNS QQSNEQTDPE PEENETKKES SVPMCQGELR HWKTGHYTLI HDHSKAEFAL DLILYCGCEG WEPEYGGFTS YIAKGEDEEL LTVNPESNSL ALVYRDRETL KFVKHINHRS LEQKKTFPNR TGFWDFSFIY YE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation.
  • 基因功能参考文献：
    1. Propose that OGFOD1 is required for breast cancer cell proliferation and is associated with poor prognosis in breast cancer. PMID: 25909288
    2. OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation. PMID: 24550447
    3. OGFOD1 plays an important role in ischemic cell survival and an OGFOD1 iron binding residue is required for ATPAF1 gene expression. PMID: 20579638
    4. Data suggest that OGFOD1 plays important proapoptotic roles in the regulation of translation and HRI-mediated phosphorylation of eIF2alpha in cells subjected to arsenite-induced stress. PMID: 20154146
  • 亚细胞定位：
    [Isoform 1]: Cytoplasm. Nucleus. Note=Mainly nuclear. A portion relocalizes to cytoplasmic stress granules upon stress.; [Isoform 2]: Cytoplasm.
  • 蛋白家族：
    TPA1 family
  • 数据库链接：

    HGNC: 25585

    OMIM: 615857

    KEGG: hsa:55239

    STRING: 9606.ENSP00000457258

    UniGene: Hs.231883

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