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  4. Recombinant Human 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (COQ5)

Recombinant Human 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (COQ5)

  • 中文名称：
    Recombinant Human 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial(COQ5)
  • 货号：
    CSB-YP708384HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial(COQ5)
  • 货号：
    CSB-EP708384HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial(COQ5)
  • 货号：
    CSB-EP708384HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial(COQ5)
  • 货号：
    CSB-BP708384HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial(COQ5)
  • 货号：
    CSB-MP708384HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    COQ5
  • Uniprot No.：
    Q5HYK3
  • 别名：
    COQ52-methoxy-6-polyprenyl-1,4-benzoquinol methylase; mitochondrial; EC 2.1.1.201; Ubiquinone biosynthesis methyltransferase COQ5
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    50-327
  • 氨基酸序列
    A ETHFGFETVS EEEKGGKVYQ VFESVAKKYD VMNDMMSLGI HRVWKDLLLW KMHPLPGTQL LDVAGGTGDI AFRFLNYVQS QHQRKQKRQL RAQQNLSWEE IAKEYQNEED SLGGSRVVVC DINKEMLKVG KQKALAQGYR AGLAWVLGDA EELPFDDDKF DIYTIAFGIR NVTHIDQALQ EAHRVLKPGG RFLCLEFSQV NNPLISRLYD LYSFQVIPVL GEVIAGDWKS YQYLVESIRR FPSQEEFKDM IEDAGFHKVT YESLTSGIVA IHSGFKL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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COQ5 antibodies

靶点详情

  • 功能：
    Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
  • 基因功能参考文献：
    1. This is the first report of primary CoQ10 deficiency caused by loss of function of COQ5, with delineation of the clinical, laboratory, histological, and molecular features, and insights regarding targeted treatment with CoQ10 supplementation. PMID: 29044765
    2. The expression of COQ5 was increased. PMID: 27155576
    3. The results that knockdown of the COQ5 gene reduced CoQ10 levels further indicated the critical role of COQ5 in the biosynthesis of CoQ10. PMID: 23354120
  • 亚细胞定位：
    Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
  • 蛋白家族：
    Class I-like SAM-binding methyltransferase superfamily, MenG/UbiE family
  • 组织特异性：
    Widely expressed, with highest levels in liver, lung, placenta and skeletal muscle.
  • 数据库链接：

    HGNC: 28722

    OMIM: 616359

    KEGG: hsa:84274

    STRING: 9606.ENSP00000288532

    UniGene: Hs.17250

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