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  4. Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 (PLCH2), partial

Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 (PLCH2), partial

  • 中文名称：
    人PLCH2重组蛋白
  • 货号：
    CSB-YP018137HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PLCH2重组蛋白
  • 货号：
    CSB-EP018137HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PLCH2重组蛋白
  • 货号：
    CSB-EP018137HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PLCH2重组蛋白
  • 货号：
    CSB-BP018137HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PLCH2重组蛋白
  • 货号：
    CSB-MP018137HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PLCH2
  • Uniprot No.：
    O75038
  • 别名：
    1-phosphatidylinositol-4; 5-bisphosphate phosphodiesterase eta-2; KIAA0450; Phosphoinositide phospholipase C-eta-2; Phosphoinositide phospholipase C-like 4; Phospholipase C-eta-2; Phospholipase C-like protein 4; PLC-eta2; PLC-L4; Plch2; PLCH2_HUMAN; PLCL4
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain.
  • 基因功能参考文献：
    1. PLCH2 might be a putative candidate gene for the neurodevelopmental delay observed in patients bearing 1p36.3 deletions. PMID: 21474938
    2. The researchers investigated the D1S80 minisatellite and associated single nucelotide polymorphisms in a Tamil population in India. PMID: 20649401
    3. molecular cloning of PLC-eta1 and PLC-eta2 PMID: 15583837
    4. PLC(eta)2 is a neuron-specific isozyme that may be important for the formation and/or maintenance of the neuronal network in the postnatal brain PMID: 15899900
    5. The molecular cloning and sequencing of phospholipase C eta2 are reported. PMID: 16107206
    6. Purified Gbeta 1gamma 2 stimulated the activity of purified PLC-eta2 in a concentration-dependent manner similar to that observed with purified PLC-beta2. PMID: 18361507

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  • 亚细胞定位：
    Cytoplasm. Cell membrane.
  • 组织特异性：
    Expressed in retina and kidney.
  • 数据库链接：

    HGNC: 29037

    OMIM: 612836

    KEGG: hsa:9651

    STRING: 9606.ENSP00000367747

    UniGene: Hs.170156

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