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  4. Recombinant Guinea pig Nitric oxide synthase, inducible (NOS2), partial

Recombinant Guinea pig Nitric oxide synthase, inducible (NOS2), partial

  • 中文名称：
    Recombinant Guinea pig Nitric oxide synthase, inducible(NOS2) ,partial
  • 货号：
    CSB-YP015943GU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Guinea pig Nitric oxide synthase, inducible(NOS2) ,partial
  • 货号：
    CSB-EP015943GU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Guinea pig Nitric oxide synthase, inducible(NOS2) ,partial
  • 货号：
    CSB-EP015943GU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Guinea pig Nitric oxide synthase, inducible(NOS2) ,partial
  • 货号：
    CSB-BP015943GU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Guinea pig Nitric oxide synthase, inducible(NOS2) ,partial
  • 货号：
    CSB-MP015943GU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NOS2
  • Uniprot No.：
    O54705
  • 别名：
    NOS2; NOSNitric oxide synthase; inducible; EC 1.14.13.39; Inducible NO synthase; Inducible NOS; iNOS; NOS type II; Peptidyl-cysteine S-nitrosylase NOS2
  • 种属：
    Cavia porcellus (Guinea pig)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8.
  • 基因功能参考文献：
    1. The expression of iNOS participates in the pathogenesis of cochlear damage caused by acoustic trauma. PMID: 22687355
    2. Our data demonstrate that both iNOS and nNOS represent sources for nitric oxide overproduction in ileal myenteric plexus during ischemia and reperfusion PMID: 23279126
    3. Salvia miltiorrhiza injection had no effect on the expression of nNOS and eNOS, but could inhibit iNOS in choclea. PMID: 21845886
    4. iNOS and AChE expression increases in spiral ganglia treated with streptomycin. Salvia miltiorrhiza injection reduces ototoxicity by reducing the levels of iNOS and AChE. PMID: 21189568
    5. The auditory brainstem response threshold increases and the expression of iNOS strengthens in streptomycin ototoxicity. PMID: 21166178

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  • 亚细胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    NOS family
  • 组织特异性：
    Expressed in the lung and colon. Not detected in the heart, aorta, liver, kidney, and spleen.
  • 数据库链接：

    STRING: 10141.ENSCPOP00000017277

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