Recombinant Epstein-Barr virus Epstein-Barr nuclear antigen 1 (EBNA1), partial

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中文名称：

Recombinant Epstein-Barr virus Epstein-Barr nuclear antigen 1 (EBNA1), partial
货号：

CSB-EP627067EEZ
规格：

￥1344
图片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

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纯度：

Greater than 90% as determined by SDS-PAGE.
生物活性：

Not Test
基因名：

EBNA1
Uniprot No.：

Q1HVF7
别名：

EBNA-1;EBV nuclear antigen 1
种属：

Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4)
蛋白长度：

Partial
来源：

E.coli
分子量：

26.7 kDa
表达区域：

458-641aa
氨基酸序列

RRKKGGWYGKHRGEGGSSQKFENIAEGLRLLLARCHVERTTEDGNWVAGVFVYGGSKTSLYNLRRGIGLAIPQCRLTPLSRLPFGMAPGPGPQPGPLRESIVCYFIVFLQTHIFAEGLKDAIKDLVLPKPAPTCNIKVTVCSFDDGVDLPPWFPPMVEGAAAEGDDGDDGDEGGDGDEGEEGQE
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
蛋白标签：

C-terminal 6xHis-tagged
产品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
缓冲液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
复溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
储存条件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保质期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
货期：

3-7 business days
Datasheet & COA：

Please contact us to get it.

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功能：

Plays an essential role in replication and partitioning of viral genomic DNA during latent viral infection. During this phase, the circular double-stranded viral DNA undergoes replication once per cell cycle and is efficiently partitioned to the daughter cells. EBNA1 activates the initiation of viral DNA replication through binding to specific sites in the viral latent origin of replication, oriP. Additionally, it governs the segregation of viral episomes by mediating their attachment to host cell metaphase chromosomes. Also activates the transcription of several viral latency genes. Finally, it can counteract the stabilization of host p53/TP53 by host USP7, thereby decreasing apoptosis and increasing host cell survival.
基因功能参考文献：
1. PARP1-dependent PARylation of EBNA1 and adjacently bound TRF2 induces structural changes at the dyad symmetry element that reduce EBNA1 DNA binding affinity and functional recruitment of origin recognition complex. PMID: 20219917
亚细胞定位：

Host nucleus.
蛋白家族：

Herpesviridae EBNA1 family
数据库链接：

KEGG: vg:5176225

Recombinant Epstein-Barr virus Epstein-Barr nuclear antigen 1 (EBNA1), partial

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