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  4. Recombinant Drosophila melanogaster Zinc finger protein sens (sens), partial

Recombinant Drosophila melanogaster Zinc finger protein sens (sens), partial

  • 中文名称：
    黑腹果蝇sens重组蛋白
  • 货号：
    CSB-YP863096DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇sens重组蛋白
  • 货号：
    CSB-EP863096DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇sens重组蛋白
  • 货号：
    CSB-EP863096DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇sens重组蛋白
  • 货号：
    CSB-BP863096DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇sens重组蛋白
  • 货号：
    CSB-MP863096DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    sens
  • Uniprot No.：
    Q9N658
  • 别名：
    sens; Lyra; CG32120Zinc finger protein sens; Protein senseless
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor both necessary and sufficient for proper development of most cell types of the embryonic and adult peripheral nervous system (PNS). Essential component of the proneural Notch signaling pathway required for proper sensory organ precursor (SOP) differentiation. Correct expression requires expression of scalloped (sd). Repression of rough (ro) in R8 photoreceptor is an essential mechanism of R8 cell fate determination.
  • 基因功能参考文献：
    1. Using multigenerational selection experiments, study finds that for the Drosophila proneural network, the effect of genomic diversity is dampened by miR-9a-mediated regulation of senseless expression. PMID: 24360277
    2. propose that SUMOylation of Senseless via lysine 509 promotes its synergy with proneural proteins during transcriptional activation and hence regulates an important step in neurogenesis leading to the formation and maturation of the sense organ precursors PMID: 22586269
    3. Data found that expression of Wg target gene senseless (sens) was elevated in the sulf1 mutant wing discs. Sulf1 also negatively regulate extracellular levels of Wg. PMID: 21305649
    4. Data show that in the salivary glands, senseless acts as an anti-apoptotic protein by repressing reaper and possibly hid. PMID: 12925597
    5. acts as a binary switch that is fundamental to sensory organ precursor selection PMID: 14665671
    6. senseless is the primary target of achaete and scute during interommatidial bristle development PMID: 15083519
    7. These results indicate that the Atx-1/sensless interaction contributes to the selective Purkinje cell degeneration in SCA1. PMID: 16122429
    8. Sens confers neuronal identity to epithelial cells in the wing margin. PMID: 16554363
    9. Specificity of Atonal and Scute bHLH factors: analysis of cognate E box binding sites and the influence of sens are reported. PMID: 18681894
    10. Hox-Senseless antagonism forms a molecular switch that integrates neural and anterior-posterior positional information. PMID: 18694568

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Almost exclusively restricted to precursors and early differentiating cells of the embryonic PNS. Expressed in the R8 photoreceptor during third instar eye development beginning within the morphogenetic furrow of the eye imaginal disk.
  • 数据库链接：

    KEGG: dme:Dmel_CG32120

    STRING: 7227.FBpp0075596

    UniGene: Dm.1457

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