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  4. Recombinant Drosophila melanogaster Tyrosine-protein kinase Abl (Abl), partial

Recombinant Drosophila melanogaster Tyrosine-protein kinase Abl (Abl), partial

  • 中文名称：
    Recombinant Drosophila melanogaster Tyrosine-protein kinase Abl(Abl) ,partial
  • 货号：
    CSB-YP355528DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Tyrosine-protein kinase Abl(Abl) ,partial
  • 货号：
    CSB-EP355528DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Tyrosine-protein kinase Abl(Abl) ,partial
  • 货号：
    CSB-EP355528DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Tyrosine-protein kinase Abl(Abl) ,partial
  • 货号：
    CSB-BP355528DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Tyrosine-protein kinase Abl(Abl) ,partial
  • 货号：
    CSB-MP355528DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Abl
  • Uniprot No.：
    P00522
  • 别名：
    Abl; ABL-1; Dash; CG4032Tyrosine-protein kinase Abl; EC 2.7.10.2; D-ash; Protein abelson
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis; critical for embryonic epithelial morphogenesis regulating cell shape changes and cell migration. Plays a critical role in transducing embryonic midline repulsive cues; may regulate cytoskeletal dynamics underlying a growth cone's response to midline cues. The ability of pCC/MP2 axons to correctly interpret midline repulsive cues and stay on the ipsilateral side is dependent on the strength of both Slit/robo and Abl-dependent signaling pathways.
  • 基因功能参考文献：
    1. Abl is an essential regulator for myocyte. PMID: 24466097
    2. Abl plays a role in the organization of filamentous actin and the redistribution of the junctional protein beta-catenin at the wound margin during embryonic wound repair. PMID: 24948602
    3. Abl is required for photoreceptor cell fate maintenance, as Abl mutant photoreceptors lose neuronal markers during late pupal stages but do not re-enter a proliferative state or undergo apoptosis. PMID: 23175629
    4. Results reveal a prominent role for Abl in coordinating multiple aspects of photoreceptor morphogenesis. PMID: 21674685
    5. The main upstream stimulus activating the c-Abl/p73 pathway and neuronal apoptosis in Niemann-Pick type C neurons is oxidative stress. PMID: 20883783
    6. Dab is a bona fide component of Abl signaling in Drosophila. PMID: 20940230
    7. Mutated c-Abl stimulated the formation of F-actin branches in neurites of rat embryonic cortical neurons. The reciprocal regulation between F-actin and the c-Abl tyrosine kinase may provide a mechanism for control of actin cytoskeleton dynamics PMID: 11864995
    8. In Abl's absence, excess actin is polymerized in apical microvilli, whereas too little actin is assembled into pseudocleavage and cellularization furrows. PMID: 14676307
    9. a reduction in Abl gene dosage causes distal paralysis and axonal swellings PMID: 15975902
    10. Abl acts apically to suppress the accumulation of both Enabled (Ena) and actin in mesodermal cells during ventral furrow formation PMID: 17202187
    11. These data provide new insight into how regulated Abl activity helps direct normal development and into possible biological functions of Bcr-Abl. PMID: 17959833

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, ABL subfamily
  • 组织特异性：
    Arm and ena colocalize with Abl at adherens junctions throughout development.
  • 数据库链接：

    KEGG: dme:Dmel_CG4032

    STRING: 7227.FBpp0303166

    UniGene: Dm.5397

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