Recombinant Drosophila melanogaster Retinoblastoma family protein (Rbf), partial

1. Rbf in the somatic lineage controls germline stem cell renewal and differentiation non-autonomously via essential roles in the microenvironment of the germline lineage. PMID: 27974223
2. These results reveal that ESCRT-0 (ESCRT-0 components stam and hrs)mutants inhibit EGFR signaling by disrupting Rhomboid endosomal trafficking in the ligand-producing cells. PMID: 27056762
3. Data show that depletion of retinoblastoma factor-1 (Rbf1) is indeed associated with polarity defects in the wing and eye. PMID: 26971715
4. Rbf1-induced apoptosis activates a compensatory proliferation mechanism which also depends on Slipper and TRAF1, indicating that these two proteins seem to be key players of compensatory proliferation in Drosophila. PMID: 26825229
5. These results provide a mechanism by which Drosophila Bcl-2 family proteins can control apoptosis, and shed light on a link between Rbf1 and mitochondrial dynamics in vivo. PMID: 26208635
6. An evolutionarily conserved C-terminal "instability element" of Drosophila Rbf1 regulates cell cycle genes, and its own turnover. PMID: 25496208
7. These results show for the first time that the caspase cleavage site of RBF could be important to control the function of RBF in tissue homeostasis in vivo. PMID: 25089524
8. Insulin receptor pathway-Bam-Rbf functional interactions represent a newly identified means to regulate the correct size and organization of the posterior signaling center hematopoietic niche. PMID: 26041767
9. Rbf1, in cooperation with dE2F2 and some members of the dREAM complex, can downregulate the anti-apoptotic genes buffy and diap1, and thus promote cell death in a proliferative tissue. PMID: 25188515
10. Data indicate that Rbf1 retinoblastoma protein levels and activity are differentially regulated by phosphorylation sites. PMID: 25049232
11. conclude that dLin52 functions as a co-factor and modulates activity of members of dMyb/dREAM complex at hid promoter, thus regulating apoptosis by repressing this pro-apoptotic gene in the developing Drosophila eye PMID: 24863159
12. deregulation of TORC1 induces activation of JNK, indicate that multiple cellular stresses are induced and contribute to the synthetic-lethal interactions between RB and TSC1/TSC2 inactivation. PMID: 23447678
13. Identification of genome-wide targets of Rbf1 in the Drosophila embryo. PMID: 23173097
14. Depletion of RBF1 causes major changes in nucleotide synthesis and glutathione metabolism. PMID: 23322302
15. Rbf1 degradation dysfunction enhances cellular DNA replication in Drosphila, which parallels neoplastic cell transformation in humans. PMID: 22895052
16. The multifunctional IE domain thus provides Rbf1 flexibility for discrimination between target genes embedded in divergent cellular processes. PMID: 23086928
17. results suggest that E2F/DP complexes are essential for all genomic targeting of RBF1 PMID: 22927638
18. Detailed EMC expression analyses revealed that RBF1 suppresses expression of both endogenous and ectopic EMC protein in photoreceptors, thus explaining the synergistic effect between EMC overexpression and rbf1 mutations, and the developmental defect observed in rbf1-null ommatidia. PMID: 22193959
19. These results describe a novel, non-mitotic role for the RBF1 and dCAP-D3 proteins in activation of the Drosophila immune system and suggest dCAP-D3 has an important role at specific subsets of RBF1-dependent genes. PMID: 22496667
20. Data show that the differentiation delay phenotype is caused by decreased levels of different components of the EGFR signaling pathway in the absence of rbf and rno. PMID: 21920355
21. Data indicate that controlled degradation of Rbf1 is linked to developmental signals. PMID: 20861300
22. TSC1 regulates E2F1 expression during development and cooperates with RBF1 to control proliferation and survival. PMID: 20808898
23. Combined inactivation of pRB and hippo pathways induces dedifferentiation in the Drosophila retina. PMID: 20421993
24. Inactivation of TSC2 and Rb synergistically induce oxidative stress via increased protein synthesis, inhibited de novo lipid synthesis, and decreased reactive oxygen species scavenger enzyme SOD2 induction PMID: 20478529
25. Results describe the regulation of differentiation-specific target genes by Drosophila retinoblastoma proteins. PMID: 20176807
26. loss of ept alters nuclear cell cycle control in developing imaginal discs and the DaPKC, presenilin, and rbf1 genes as modifiers of molecular and cellular phenotypes that result from loss of ept PMID: 19855819
27. RBF blocks Cyclin D/Cdk4 induced cellular growth in the proliferating wing disc cells but not in the non-dividing eye disc cells PMID: 11880344
28. RBF1 and RBF2 interact with different subsets of E2F proteins; this enables the RBF proteins to regulate E2F-dependent transcription in distinct ways PMID: 12234932
29. RBF1 forms complexes with both E2F1/DP and E2F2/DP that cooperate to repress the expression of pre-RC genes, which helps confine DNA synthesis to sites of gene amplification. PMID: 12612083
30. role in endoreplication during Drosophila development PMID: 12881421
31. Data show that removal of p55 deregulated the expression of E2F targets that are normally repressed by dE2F2/RBF-1 and -2 complexes in a cell cycle-independent manner but had no effect on the expression of targets normally coupled with cell proliferation. PMID: 15456884
32. Results describe the purification of E2F transcription factor/retinoblastoma tumor suppressor protein repressor complexes from Drosophila embryo extracts and characterize their roles in E2F regulation. PMID: 15479636
33. Rbf1 and Rbf2 proteins are coexpressed at several stages of development, however, spatial and temporal differences are evident, including partly complementary patterns of expression in the embryonic central nervous system. PMID: 15661648
34. Expression of the gene Retinoblastoma-family protein (Rbf) is downregulated in tumours and this downregulation is associated with DNA hypermethylation PMID: 16437107
35. Rbf is the Drosophila homologue of the retinoblastoma tumor-suppressor gene (Rb), thus it represents a novel link between Notch signaling, tumor growth and metastasis PMID: 16850405
36. gradient of epidermal growth factor receptor/ras/raf signaling that occurs naturally during development provides the contextual signals that determine when and where the inactivation of rbf1 results in dE2F1-dependent apoptosis PMID: 16954388
37. the initial downregulation of expression of the E2f1-target gene RnrS, which occurs during cycles 15 and 16 prior to entry into G1(17), does not require Rbf1 or p27(Dap) PMID: 17185321
38. PP1 is not a major regulator of the Rbf1/E2F1 pathway in Drosophila PMID: 17676643
39. Thease results demonstrate epigenetic regulation of gene expression by Myb, and E2F2-RBF in vivo, and also provide an explanation for the ability of Mip130-null mutants to rescue the lethality of Myb-null mutants in vivo. PMID: 18316477
40. rbf1 mutant larvae have extensive defects in chromatin condensation during mitosis. a novel interaction between RBF1 and dCAP-D3 PMID: 18367646
41. the N-terminal domain of the Drosophila retinoblastoma protein Rbf1 interacts with ORC and associates with chromatin in an E2F independent manner PMID: 18665226
42. pRb-independent inhibition of E2F during S phase is an evolutionarily conserved feature of the metazoan cell cycle that is necessary for development PMID: 19081076
43. These observations indicate that apoptosis of rbf mutant cells is mediated by an upregulation of hid. PMID: 19100727
44. Rbf physically and genetically interacts with Sqd. PMID: 19364495
45. Data show that removal of transcriptional activation of dE2F1 partially restores Delta expression in rbf,rno mutant clones and suppresses differentiation defects, indicating that this differentiation function of RBF is mediated by regulation of dE2F1. PMID: 19744473

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KEGG: dme:Dmel_CG7413

STRING: 7227.FBpp0070141

UniGene: Dm.4654