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  4. Recombinant Drosophila melanogaster Protein tramtrack, alpha isoform (ttk), partial

Recombinant Drosophila melanogaster Protein tramtrack, alpha isoform (ttk), partial

  • 中文名称：
    黑腹果蝇ttk重组蛋白
  • 货号：
    CSB-YP337028DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇ttk重组蛋白
  • 货号：
    CSB-EP337028DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇ttk重组蛋白
  • 货号：
    CSB-EP337028DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇ttk重组蛋白
  • 货号：
    CSB-BP337028DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇ttk重组蛋白
  • 货号：
    CSB-MP337028DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ttk
  • Uniprot No.：
    P42282
  • 别名：
    ttk; FTZ-F2; CG1856; Protein tramtrack; alpha isoform; Repressor protein fushi tarazu; Tramtrack p88
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds to a number of sites in the transcriptional regulatory region of ftz. Isoform alpha is required to repress genes that promote the R7 cell fate. Probable repressor of the transcription of the segmentation genes ftz, eve, h, odd, run, and en. May bind to the region 5'-AGGG[CT]GG-3'. Degradation of ttk is directed by binding of sinah or sina, via the adapter molecule phyl which binds to the BTB domain of ttk.
  • 基因功能参考文献：
    1. Ttk69 acts as a master repressor of enteroendocrine cell specification in Drosophila intestinal stem cell lineages. PMID: 26293304
    2. The presence and timing of ttk69 expression are essential for somatic muscle development and required for the balance between founder cells and fusion-competent myoblasts. PMID: 24961800
    3. Tramtrack69 functions as a developmental switch in Drosophila follicle cells where it is regulated by miR-7. PMID: 23325762
    4. Ttk69 plays an instructive role in the growth of R7 photoreceptor axon terminals PMID: 23345225
    5. The GBS two-component system CovS/CovR, which is the major acid response regulator in this organism, is required for survival inside the phagosome of macrophages. PMID: 22331428
    6. discovered multiple roles of Ttk in the development of the tracheal system on the morphogenetic level. Here, we sought to identify some of the underlying genetic components that are responsible for the tracheal phenotypes of Ttk mutants PMID: 22216153
    7. TTK69 is able to bind chromatin in the absence of NuRD, but targeting of NuRD is dependent on TTK69. PMID: 20733004
    8. Tramtrack69 (TTK69) controls the fates and shapes of all columnar follicle cells PMID: 19934014
    9. Using neural repression as an assay, we dissected functional domains of Ttk, confirming the importance of the bric-a-brac-tramtrack-broad complex (BTB) motif. PMID: 12204250
    10. directly regulates the transcription of string and thereby cell proliferation PMID: 12447387
    11. identification of a novel allele of tramtrack PMID: 12490195
    12. the binding of TTK69 prevents the interaction of GAGA with the transcription machinery and compromises its activation potential PMID: 14701830
    13. Tramtrack downregulates Cyclin E expression and is probably involved in the exit of cells from the cell cycle. PMID: 15829522
    14. Results suggest that the involvement of Tramtrack in different steps of tube morphogenesis identifies it as a key player in tracheal development. PMID: 17881489
    15. Sina protein may direct the degradation of the transcriptional repressor Tramtrack (Ttk) using two different mechanisms. PMID: 17962185
    16. Deubiquitinylating enzyme UBP64 controls cell fate through stabilization of tkk. PMID: 18160715
    17. Tramtrack (Ttk), a zinc-finger protein, is essential for the endocycle/gene amplification switch, is regulated negatively by Notch and positively by EcR. PMID: 18779369

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: dme:Dmel_CG1856

    STRING: 7227.FBpp0085186

    UniGene: Dm.1526

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