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  4. Recombinant Drosophila melanogaster Protein suppressor of hairy wing (su (Hw)), partial

Recombinant Drosophila melanogaster Protein suppressor of hairy wing (su (Hw)), partial

  • 中文名称：
    黑腹果蝇su(Hw)重组蛋白
  • 货号：
    CSB-YP357541DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇su(Hw)重组蛋白
  • 货号：
    CSB-EP357541DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇su(Hw)重组蛋白
  • 货号：
    CSB-EP357541DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇su(Hw)重组蛋白
  • 货号：
    CSB-BP357541DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇su(Hw)重组蛋白
  • 货号：
    CSB-MP357541DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    su(Hw)
  • Uniprot No.：
    P08970
  • 别名：
    su(Hw); CG8573; Protein suppressor of hairy wing
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops. This chromatin looping may involve the formation of insulator bodies, where homotypic interactions between individual subunits of the insulator complex could promote the clustering of widely spaced insulators at the nuclear periphery. Within the gypsy insulator complex, this protein binds specifically to a region of the gypsy element located 3' of the 5' long terminal repeat (LTR), and may also mediate interaction with other endogenous insulators at sites distinct from those recognized by Cp190.
  • 基因功能参考文献：
    1. Study highlights that Su(Hw) has a major developmental function as a transcriptional repressor, with the effect of its loss dependent upon the cell-specific factors. PMID: 29739818
    2. the role of the Su(Hw) protein in Drosophila oogenesis as a transcription repressor PMID: 29779102
    3. Role of Su(Hw) zinc finger 10 and interaction with CP190 and Mod(mdg4) proteins in recruiting the Su(Hw) complex to chromatin sites in Drosophila PMID: 29474480
    4. Su(Hw) genomic sites separate into sequence subclasses comprised of combinations of modules, with subclasses enriched for different chromatin features. PMID: 28158673
    5. Study of the role of Mod(mdg4)-67.2 and Su(Hw) proteins in the interaction between Su(Hw)-dependent insulator complexes and identifying the specific domains of the Su(Hw) protein required for insulation or mutual neutralization of insulators; demonstrated that the Su(Hw) protein zinc finger domain is involved in forming a functional insulator complex and cannot be replaced with the DNA-binding domain of the GAL4 protein PMID: 27599504
    6. It was demonstrated that the interaction of Su(Hw) and Mod(mdg4)-67.2 insulator proteins with the terminator regions of the selected genes was dependent on the Su(Hw) factor. PMID: 26845853
    7. loss of su(Hw) affects expression of many oogenesis related genes and down-regulates Src64B, resulting in ring canal defects potentially contributing to obstruction of molecular flow and an eventual failure of egg chamber organization. PMID: 25882370
    8. The insulator protein Suppressor of Hairy-wing is an essential transcriptional repressor in the Drosophila ovary. PMID: 23884443
    9. Completion of the first genome-wide analysis of Su(Hw)-binding sites in the ovary, shows that tissue-specific binding is not responsible for the restricted developmental requirements for Su(Hw). PMID: 22406832
    10. Accumulation of these proteins is distinct from Su(Hw), with Mod67.2 and CP190 showing uniform expression in all cells during early stages of oogenesis that diminishes in later stages PMID: 21651900
    11. Studies identify SU(HW) as a fine-tuner of genome - NL interactions. PMID: 21124834
    12. Data show that gypsy-Su(Hw) system enhanced expression levels, but did not alter the specificity of promoter activities. PMID: 20516496
    13. most Su(Hw) binding sites are largely associated with compacted chromatin and that Su (Hw) binding sites associated with open chromatin in interbands may have properties different from Su(Hw) binding sites found in condensed chromatin. PMID: 20033198
    14. Suppressor of Hairy wing and Modifier of MDG4 are involved in the transcriptional regulation of Achaete-scute PMID: 12783795
    15. Su(Hw) insulator's actions in the absence of the Mod(mdg4) protein PMID: 12856417
    16. 1A-2 is an endogenous Su(Hw) insulator that separates regulatory domains within the Drosophila genome PMID: 14597701
    17. The Su(Hw) insulator can modulate interactions between transposase complexes bound to the ends of the P transposon in germ cells. PMID: 15280241
    18. Su(Hw) insulator can stimulate transcription of a weakened yellow promoter over a distance. PMID: 15520254
    19. Analysis of interaction between the insulator Su(Hw) and the regulatory elements of the Abdominal-B gene of Drosophila melanogaster. PMID: 15584504
    20. Analysis of the effect of the Su(Hw) insulator on the expression of the miniwhite gene in Drosophila melanogaster. PMID: 15584507
    21. analysis of the role of the acid domain located at the C-terminus of the Su(Hw) protein PMID: 15846971
    22. Su(Hw) regulates an evolutionarily conserved silencer from the mouse H19 imprinting control region. PMID: 16117632
    23. Polycomb group response elements (PRE) silence neighboring genes, but silencing can be blocked by one copy of the Su(Hw) insulator element. PRE-mediated silencing can bypass two Su(Hw) insulators to repress a downstream reporter gene. PMID: 16824958
    24. These studies provide the first direct evidence that the Su(Hw) protein contributes to the regulation of gene expression in the Drosophila genome through the establishment of endogenous insulators. PMID: 16880510
    25. E(y)2/Sus1, is recruited to the Su(Hw) insulators via binding to the zinc-finger domain of Su(Hw). PMID: 17643381
    26. A mutant Mod(mdg4) protein devoid of the Q-rich domain supports the function of Su(Hw)-dependent insulators and efficiently binds to correct insulator sites on the chromosome, but does not form or enter the Su(Hw)-marked nuclear speckles. PMID: 18369369
    27. These studies extend the understanding of the properties of Su(Hw) and the endogenous genomic regions to which this protein localizes. PMID: 18562648
    28. transcription factor E(y)2/Sus1 interacted with the Su(Hw) zinc-finger domain and was present in the protein complex, associated with the Su(Hw)-dependent insulators. PMID: 19382683

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  • 亚细胞定位：
    Nucleus. Chromosome. Note=Colocalizes with other elements of the gypsy chromatin insulator complex at multiple sites on polytene chromosomes and at nuclear insulator bodies.
  • 数据库链接：

    KEGG: dme:Dmel_CG8573

    STRING: 7227.FBpp0082404

    UniGene: Dm.2430

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