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  4. Recombinant Drosophila melanogaster Protein nubbin (nub), partial

Recombinant Drosophila melanogaster Protein nubbin (nub), partial

  • 中文名称：
    黑腹果蝇nub重组蛋白
  • 货号：
    CSB-YP329066DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇nub重组蛋白
  • 货号：
    CSB-EP329066DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇nub重组蛋白
  • 货号：
    CSB-EP329066DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇nub重组蛋白
  • 货号：
    CSB-BP329066DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇nub重组蛋白
  • 货号：
    CSB-MP329066DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    nub
  • Uniprot No.：
    P31368
  • 别名：
    nub; OCT1; pdm-1; POU-19; TWN; CG34395; Protein nubbin; POU domain protein 1; PDM-1; Protein twain; dOCT1; dPOU-19
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    DNA-binding regulatory protein implicated in early development. Involved in neuronal cell fate decision. Repressed directly or indirectly by the BX-C homeotic proteins.
  • 基因功能参考文献：
    1. Overexpression of Nub-PB enhanced bacterial clearance of ingested Erwinia carotovora carotovora 15 PMID: 29499056
    2. this study shows that Pdm1 is necessary for a beneficial gut microbiota and normal lifespan PMID: 27231014
    3. We suggest that Nub protein plays an ancient role, shared with mammalian Oct/POU transcription factors, to moderate responses to immune challenge, thereby increasing the tolerance to biotic stress. PMID: 24010524
    4. Pdm-1 and Drosophila octamer elements dictate the coordinated transcription of core histone genes PMID: 20097756
    5. maintaining high levels of Mitimere or Nubbin, two POU proteins, in a ganglion mother cell causes it to undergo self-renewing asymmetric divisions PMID: 14973280
    6. Pdm and Cas specify late-born neuronal identity; that Pdm and Cas act combinatorially to specify a temporal identity distinct from either protein alone, and that Cas repression of pdm expression regulates the generation of neuronal diversity. PMID: 16980589
    7. Nub and Tsh domains share some of the attributes of classical compartments, but lack their stringent and immobile boundaries. PMID: 17313943
    8. These results provide a new neuroblast lineage for investigating temporal identity and reveal the importance of Pdm and Cas as timing factors that close temporal identity windows. PMID: 18832394

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    POU transcription factor family, Class-2 subfamily
  • 组织特异性：
    Initial expression in cellular blastoderm stage, then in ectodermal stripes during germband extension. Broad expression in the neuroectoderm followed by limitation to discrete subsets of CNS cells, and expression in specific PNS neurons and support cells.
  • 数据库链接：

    KEGG: dme:Dmel_CG34395

    STRING: 7227.FBpp0111554

    UniGene: Dm.4744

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